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C6W223

- C6W223_DYAFD

UniProt

C6W223 - C6W223_DYAFD

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Protein

Thymidine kinase

Gene

tdk

Organism
Dyadobacter fermentans (strain ATCC 700827 / DSM 18053 / NS114)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971Proton acceptorUniRule annotation
Metal bindingi153 – 1531ZincUniRule annotation
Metal bindingi156 – 1561ZincUniRule annotation
Metal bindingi185 – 1851ZincUniRule annotation
Metal bindingi188 – 1881ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318ATPUniRule annotation
Nucleotide bindingi96 – 994ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciDFER471854:GI24-4435-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Dfer_4396Imported
OrganismiDyadobacter fermentans (strain ATCC 700827 / DSM 18053 / NS114)Imported
Taxonomic identifieri471854 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeDyadobacter
ProteomesiUP000002011: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi471854.Dfer_4396.

Structurei

3D structure databases

ProteinModelPortaliC6W223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiQAICLSC.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C6W223-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFVEPSHRRE FQNPRTGWIE VICGSMFSGK TEELIRLLNR ARIARQRIQI
60 70 80 90 100
FKPALDKRYH EENIVSHNDN SIPSIPVQSS QQISDLAQDC EVVGIDEAQF
110 120 130 140 150
FDEGILAVCD QLANSGKRVI VAGLDMDYMG KPFGCMPQLM AIAEYVTKVH
160 170 180 190 200
AVCMVCGEVA SHSYRLSPSN ERVLLGETDH YEARCRRCFN LGEKATELFS

R
Length:201
Mass (Da):22,771
Last modified:September 22, 2009 - v1
Checksum:iCB8394C86ED6918F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001619 Genomic DNA. Translation: ACT95598.1.
RefSeqiYP_003088763.1. NC_013037.1.

Genome annotation databases

EnsemblBacteriaiACT95598; ACT95598; Dfer_4396.
GeneIDi8227999.
KEGGidfe:Dfer_4396.
PATRICi21830397. VBIDyaFer416_4520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001619 Genomic DNA. Translation: ACT95598.1 .
RefSeqi YP_003088763.1. NC_013037.1.

3D structure databases

ProteinModelPortali C6W223.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471854.Dfer_4396.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACT95598 ; ACT95598 ; Dfer_4396 .
GeneIDi 8227999.
KEGGi dfe:Dfer_4396.
PATRICi 21830397. VBIDyaFer416_4520.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
KOi K00857.
OMAi QAICLSC.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci DFER471854:GI24-4435-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700827 / DSM 18053 / NS114Imported.

Entry informationi

Entry nameiC6W223_DYAFD
AccessioniPrimary (citable) accession number: C6W223
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: November 26, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3