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Protein

Thymidine kinase

Gene

tdk

Organism
Dyadobacter fermentans (strain ATCC 700827 / DSM 18053 / NS114)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971Proton acceptorUniRule annotation
Metal bindingi153 – 1531ZincUniRule annotation
Metal bindingi156 – 1561ZincUniRule annotation
Metal bindingi185 – 1851ZincUniRule annotation
Metal bindingi188 – 1881ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318ATPUniRule annotation
Nucleotide bindingi96 – 994ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciDFER471854:GI24-4435-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Dfer_4396Imported
OrganismiDyadobacter fermentans (strain ATCC 700827 / DSM 18053 / NS114)Imported
Taxonomic identifieri471854 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeDyadobacter
ProteomesiUP000002011 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi471854.Dfer_4396.

Structurei

3D structure databases

ProteinModelPortaliC6W223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiVTKVHAI.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C6W223-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVEPSHRRE FQNPRTGWIE VICGSMFSGK TEELIRLLNR ARIARQRIQI
60 70 80 90 100
FKPALDKRYH EENIVSHNDN SIPSIPVQSS QQISDLAQDC EVVGIDEAQF
110 120 130 140 150
FDEGILAVCD QLANSGKRVI VAGLDMDYMG KPFGCMPQLM AIAEYVTKVH
160 170 180 190 200
AVCMVCGEVA SHSYRLSPSN ERVLLGETDH YEARCRRCFN LGEKATELFS

R
Length:201
Mass (Da):22,771
Last modified:September 22, 2009 - v1
Checksum:iCB8394C86ED6918F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001619 Genomic DNA. Translation: ACT95598.1.
RefSeqiWP_015813841.1. NC_013037.1.

Genome annotation databases

EnsemblBacteriaiACT95598; ACT95598; Dfer_4396.
KEGGidfe:Dfer_4396.
PATRICi21830397. VBIDyaFer416_4520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001619 Genomic DNA. Translation: ACT95598.1.
RefSeqiWP_015813841.1. NC_013037.1.

3D structure databases

ProteinModelPortaliC6W223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi471854.Dfer_4396.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACT95598; ACT95598; Dfer_4396.
KEGGidfe:Dfer_4396.
PATRICi21830397. VBIDyaFer416_4520.

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiVTKVHAI.
OrthoDBiEOG69D3J2.

Enzyme and pathway databases

BioCyciDFER471854:GI24-4435-MONOMER.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700827 / DSM 18053 / NS114Imported.

Entry informationi

Entry nameiC6W223_DYAFD
AccessioniPrimary (citable) accession number: C6W223
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: July 22, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.