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C6W223

- C6W223_DYAFD

UniProt

C6W223 - C6W223_DYAFD

Protein

Thymidine kinase

Gene

tdk

Organism
Dyadobacter fermentans (strain ATCC 700827 / DSM 18053 / NS114)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei97 – 971Proton acceptorUniRule annotation
    Metal bindingi153 – 1531ZincUniRule annotation
    Metal bindingi156 – 1561ZincUniRule annotation
    Metal bindingi185 – 1851ZincUniRule annotation
    Metal bindingi188 – 1881ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi24 – 318ATPUniRule annotation
    Nucleotide bindingi96 – 994ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciDFER471854:GI24-4435-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:Dfer_4396Imported
    OrganismiDyadobacter fermentans (strain ATCC 700827 / DSM 18053 / NS114)Imported
    Taxonomic identifieri471854 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeDyadobacter
    ProteomesiUP000002011: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi471854.Dfer_4396.

    Structurei

    3D structure databases

    ProteinModelPortaliC6W223.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1435.
    HOGENOMiHOG000076390.
    KOiK00857.
    OMAiQAICLSC.
    OrthoDBiEOG69D3J2.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C6W223-1 [UniParc]FASTAAdd to Basket

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    MFVEPSHRRE FQNPRTGWIE VICGSMFSGK TEELIRLLNR ARIARQRIQI    50
    FKPALDKRYH EENIVSHNDN SIPSIPVQSS QQISDLAQDC EVVGIDEAQF 100
    FDEGILAVCD QLANSGKRVI VAGLDMDYMG KPFGCMPQLM AIAEYVTKVH 150
    AVCMVCGEVA SHSYRLSPSN ERVLLGETDH YEARCRRCFN LGEKATELFS 200
    R 201
    Length:201
    Mass (Da):22,771
    Last modified:September 22, 2009 - v1
    Checksum:iCB8394C86ED6918F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001619 Genomic DNA. Translation: ACT95598.1.
    RefSeqiYP_003088763.1. NC_013037.1.

    Genome annotation databases

    EnsemblBacteriaiACT95598; ACT95598; Dfer_4396.
    GeneIDi8227999.
    KEGGidfe:Dfer_4396.
    PATRICi21830397. VBIDyaFer416_4520.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001619 Genomic DNA. Translation: ACT95598.1 .
    RefSeqi YP_003088763.1. NC_013037.1.

    3D structure databases

    ProteinModelPortali C6W223.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 471854.Dfer_4396.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACT95598 ; ACT95598 ; Dfer_4396 .
    GeneIDi 8227999.
    KEGGi dfe:Dfer_4396.
    PATRICi 21830397. VBIDyaFer416_4520.

    Phylogenomic databases

    eggNOGi COG1435.
    HOGENOMi HOG000076390.
    KOi K00857.
    OMAi QAICLSC.
    OrthoDBi EOG69D3J2.

    Enzyme and pathway databases

    BioCyci DFER471854:GI24-4435-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700827 / DSM 18053 / NS114Imported.

    Entry informationi

    Entry nameiC6W223_DYAFD
    AccessioniPrimary (citable) accession number: C6W223
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 22, 2009
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3