C6VM79 (C6VM79_LACPJ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
S-ribosylhomocysteine lyase HAMAP MF_00091
EC=4.4.1.21 HAMAP MF_00091

Alternative name(s):
AI-2 synthesis protein HAMAP MF_00091
Autoinducer-2 production protein LuxS HAMAP MF_00091

Gene names

Name:	luxS HAMAP MF_00091 EMBL ACT61529.1
Ordered Locus Names:	JDM1_0641

Organism

Lactobacillus plantarum (strain JDM1) [Complete proteome] [HAMAP]

Taxonomic identifier

644042 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity. HAMAP MF_00091 SAAS SAAS003815
Catalytic activity	S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione. HAMAP MF_00091 SAAS SAAS003815
Cofactor	Binds 1 iron ion per subunit By similarity. HAMAP MF_00091 SAAS SAAS003815
Subunit structure	Homodimer By similarity. HAMAP MF_00091 SAAS SAAS003815
Sequence similarities	Belongs to the LuxS family. HAMAP MF_00091

Ontologies

Keywords
Biological process	Autoinducer synthesis HAMAP MF_00091 SAAS SAAS003815 Quorum sensing HAMAP MF_00091 SAAS SAAS003815
Ligand	Iron HAMAP MF_00091 SAAS SAAS003815 Metal-binding HAMAP MF_00091 SAAS SAAS003815
Molecular function	Lyase HAMAP MF_00091 SAAS SAAS003815
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	quorum sensing Inferred from electronic annotation. Source: HAMAP
Molecular function	S-ribosylhomocysteine lyase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	54	1	Iron By similarity HAMAP MF_00091
	Metal binding	58	1	Iron By similarity HAMAP MF_00091
	Metal binding	124	1	Iron By similarity HAMAP MF_00091

Sequences

	Sequence		Length	Mass (Da)
	C6VM79 [UniParc]. Last modified September 22, 2009. Version 1. Checksum: 3EC768414712AE05	FASTA	158	17,428
	10 20 30 40 50 60 MAKVESFTLD HTKVLAPYVR KITVENGPKG DAITNFDLRL VQPNKTAIDT AGLHTIEHML 70 80 90 100 110 120 AGLLRDRMDG VIDCSPFGCR TGFHLITWGE HDTVEVAKAL KSSLEFIAGP AKWEDVQGTT 130 140 150 IDSCGNYKDH SLFSAKEWAK LILSQGISSD PFVRKVVE

References

[1]	"Complete genome sequence of Lactobacillus plantarum JDM1." Zhang Z.-Y., Liu C., Zhu Y.-Z., Zhong Y., Zhu Y.-Q., Zheng H.-J., Zhao G.-P., Wang S.-Y., Guo X.-K. J. Bacteriol. 191:5020-5021(2009) [PubMed: 19465650] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001617 Genomic DNA. Translation: ACT61529.1.
RefSeq	YP_003062226.1. NC_012984.1.
3D structure databases
ProteinModelPortal	C6VM79.
ModBase	Search...
Protein-protein interaction databases
STRING	C6VM79.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8188641.
GenomeReviews	Gene locus JDM1_0641 in contig CP001617_GR.
KEGG	lpj:JDM1_0641.
PATRIC	22241813. VBILacPla68346_0639.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	TTFDIRM.
ProtClustDB	PRK02260.
Family and domain databases
HAMAP	MF_00091. LuxS. [Tree]
InterPro	IPR011249. Metalloenz_metal-bd. IPR003815. S-ribosylhomocysteinase. [Graphical view]
Gene3D	G3DSA:3.30.1360.80. S-ribosylhomocysteinase. 1 hit.
KO	K07173.
Pfam	PF02664. LuxS. 1 hit. [Graphical view]
PIRSF	PIRSF006160. AI2. 1 hit.
PRINTS	PR01487. LUXSPROTEIN.
ProDom	PD013172. S-ribosylhomocysteinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF63411. Metalloenz_metal-bd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C6VM79_LACPJ

Accession

Primary (citable) accession number: C6VM79

Entry history

Integrated into UniProtKB/TrEMBL:	September 22, 2009
Last sequence update:	September 22, 2009
Last modified:	December 14, 2011
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)