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C6V4W6 (C6V4W6_NEORI) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable cytosol aminopeptidase HAMAP-Rule MF_00181

EC=3.4.11.1 HAMAP-Rule MF_00181
Alternative name(s):
Leucine aminopeptidase HAMAP-Rule MF_00181
Leucyl aminopeptidase HAMAP-Rule MF_00181
Gene names
Name:pepA HAMAP-Rule MF_00181
Ordered Locus Names:NRI_0450 EMBL ACT69436.1
OrganismNeorickettsia risticii (strain Illinois) [Complete proteome] [HAMAP] EMBL ACT69436.1
Taxonomic identifier434131 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia

Protein attributes

Sequence length506 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides By similarity. HAMAP-Rule MF_00181 SAAS SAAS011356

Catalytic activity

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low. HAMAP-Rule MF_00181 SAAS SAAS011356

Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids. HAMAP-Rule MF_00181

Cofactor

Binds 2 manganese ions per subunit By similarity. HAMAP-Rule MF_00181

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00181 SAAS SAAS011356.

Sequence similarities

Belongs to the peptidase M17 family. HAMAP-Rule MF_00181

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2781 By similarity HAMAP-Rule MF_00181
Active site3521 By similarity HAMAP-Rule MF_00181
Metal binding2661Manganese 2 By similarity HAMAP-Rule MF_00181
Metal binding2711Manganese 1 By similarity HAMAP-Rule MF_00181
Metal binding2711Manganese 2 By similarity HAMAP-Rule MF_00181
Metal binding2891Manganese 2 By similarity HAMAP-Rule MF_00181
Metal binding3481Manganese 1 By similarity HAMAP-Rule MF_00181
Metal binding3501Manganese 1 By similarity HAMAP-Rule MF_00181
Metal binding3501Manganese 2 By similarity HAMAP-Rule MF_00181

Sequences

Sequence LengthMass (Da)Tools
C6V4W6 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: CFFECDAD256EBCAB

FASTA50654,634
        10         20         30         40         50         60 
MEVFFLSPVE AMQSEPILFS GLYENSEFFG RISILDQQSS SFISKSIAST SFTGKIGENV 

        70         80         90        100        110        120 
CIFLSDLVEG YPKLQQLCLI GLGKQKDFGA HTAEKIGTQI ASLMKKNNVS SATVLLDGLK 

       130        140        150        160        170        180 
DDYALDLAFG AKVKDYSFNK YKTKKVDDKS ITLERLVIGI ENYEHICSVF REKVEPLIES 

       190        200        210        220        230        240 
IKLTRDLINE PANHLNPETY ANAVREITKT APNLKIEILD EKIMQKLGMN ALLGVGQGSA 

       250        260        270        280        290        300 
YPSRLAVVKY NGAVDKDEPY IALVGKGVTF DSGGISLKPA RGMWHMISDM AGSATVLGAI 

       310        320        330        340        350        360 
HAVAKKGVKA NVAAVLGIVE NAVSGVAQRP GDVVKSASGK TIEVLNTDAE GRLVLADALW 

       370        380        390        400        410        420 
YAQEHLKANQ VIDVATLTGA IVVALGHDHA GLFSNDDVLA ENLANIGKKV GEKLWRMPMS 

       430        440        450        460        470        480 
KNYDDLVNSE VADVKNISTE NHGADSITAA QFLKRFINDG TKWAHLDIAG VAWNNSTSHF 

       490        500 
SSTGASGFGV RLLTEFISES AKDTSK 

« Hide

References

[1]"Analysis of complete genome sequence of Neorickettsia risticii: causative agent of Potomac horse fever."
Lin M., Zhang C., Gibson K., Rikihisa Y.
Nucleic Acids Res. 37:6076-6091(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Illinois EMBL ACT69436.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001431 Genomic DNA. Translation: ACT69436.1.
RefSeqYP_003081670.1. NC_013009.1.

3D structure databases

ProteinModelPortalC6V4W6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING434131.NRI_0450.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACT69436; ACT69436; NRI_0450.
GeneID8220514.
KEGGnri:NRI_0450.
PATRIC22679184. VBINeoRis104330_0426.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0260.
HOGENOMHOG000243132.
KOK01255.
OMAPRYGGSI.
OrthoDBEOG6FV8B3.
ProtClustDBCLSK2527977.

Enzyme and pathway databases

BioCycNRIS434131:GJCC-452-MONOMER.

Family and domain databases

HAMAPMF_00181. Cytosol_peptidase_M17.
InterProIPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view]
PANTHERPTHR11963:SF3. PTHR11963:SF3. 1 hit.
PfamPF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view]
PRINTSPR00481. LAMNOPPTDASE.
PROSITEPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC6V4W6_NEORI
AccessionPrimary (citable) accession number: C6V4W6
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: February 19, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)