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C6V4W6

- C6V4W6_NEORI

UniProt

C6V4W6 - C6V4W6_NEORI

Protein

Probable cytosol aminopeptidase

Gene

pepA

Organism
Neorickettsia risticii (strain Illinois)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.UniRule annotationSAAS annotation

    Catalytic activityi

    Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotationSAAS annotation
    Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.UniRule annotation

    Cofactori

    Binds 2 manganese ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi266 – 2661Manganese 2UniRule annotation
    Metal bindingi271 – 2711Manganese 1UniRule annotation
    Metal bindingi271 – 2711Manganese 2UniRule annotation
    Active sitei278 – 2781UniRule annotation
    Metal bindingi289 – 2891Manganese 2UniRule annotation
    Metal bindingi348 – 3481Manganese 1UniRule annotation
    Metal bindingi350 – 3501Manganese 1UniRule annotation
    Metal bindingi350 – 3501Manganese 2UniRule annotation
    Active sitei352 – 3521UniRule annotation

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. metalloexopeptidase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    AminopeptidaseUniRule annotationSAAS annotationImported, Hydrolase, Protease

    Keywords - Ligandi

    ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciNRIS434131:GJCC-452-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytosol aminopeptidaseUniRule annotation
    Alternative name(s):
    Leucine aminopeptidaseUniRule annotation
    Leucyl aminopeptidaseUniRule annotation
    Gene namesi
    Name:pepAUniRule annotation
    Ordered Locus Names:NRI_0450Imported
    OrganismiNeorickettsia risticii (strain Illinois)Imported
    Taxonomic identifieri434131 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia
    ProteomesiUP000001627: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi434131.NRI_0450.

    Structurei

    3D structure databases

    ProteinModelPortaliC6V4W6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M17 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0260.
    HOGENOMiHOG000243132.
    KOiK01255.
    OMAiDSQFADM.
    OrthoDBiEOG6FV8B3.

    Family and domain databases

    HAMAPiMF_00181. Cytosol_peptidase_M17.
    InterProiIPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view]
    PfamiPF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view]
    PRINTSiPR00481. LAMNOPPTDASE.
    PROSITEiPS00631. CYTOSOL_AP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C6V4W6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVFFLSPVE AMQSEPILFS GLYENSEFFG RISILDQQSS SFISKSIAST    50
    SFTGKIGENV CIFLSDLVEG YPKLQQLCLI GLGKQKDFGA HTAEKIGTQI 100
    ASLMKKNNVS SATVLLDGLK DDYALDLAFG AKVKDYSFNK YKTKKVDDKS 150
    ITLERLVIGI ENYEHICSVF REKVEPLIES IKLTRDLINE PANHLNPETY 200
    ANAVREITKT APNLKIEILD EKIMQKLGMN ALLGVGQGSA YPSRLAVVKY 250
    NGAVDKDEPY IALVGKGVTF DSGGISLKPA RGMWHMISDM AGSATVLGAI 300
    HAVAKKGVKA NVAAVLGIVE NAVSGVAQRP GDVVKSASGK TIEVLNTDAE 350
    GRLVLADALW YAQEHLKANQ VIDVATLTGA IVVALGHDHA GLFSNDDVLA 400
    ENLANIGKKV GEKLWRMPMS KNYDDLVNSE VADVKNISTE NHGADSITAA 450
    QFLKRFINDG TKWAHLDIAG VAWNNSTSHF SSTGASGFGV RLLTEFISES 500
    AKDTSK 506
    Length:506
    Mass (Da):54,634
    Last modified:September 22, 2009 - v1
    Checksum:iCFFECDAD256EBCAB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001431 Genomic DNA. Translation: ACT69436.1.
    RefSeqiYP_003081670.1. NC_013009.1.

    Genome annotation databases

    EnsemblBacteriaiACT69436; ACT69436; NRI_0450.
    GeneIDi8220514.
    KEGGinri:NRI_0450.
    PATRICi22679184. VBINeoRis104330_0426.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001431 Genomic DNA. Translation: ACT69436.1 .
    RefSeqi YP_003081670.1. NC_013009.1.

    3D structure databases

    ProteinModelPortali C6V4W6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 434131.NRI_0450.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACT69436 ; ACT69436 ; NRI_0450 .
    GeneIDi 8220514.
    KEGGi nri:NRI_0450.
    PATRICi 22679184. VBINeoRis104330_0426.

    Phylogenomic databases

    eggNOGi COG0260.
    HOGENOMi HOG000243132.
    KOi K01255.
    OMAi DSQFADM.
    OrthoDBi EOG6FV8B3.

    Enzyme and pathway databases

    BioCyci NRIS434131:GJCC-452-MONOMER.

    Family and domain databases

    HAMAPi MF_00181. Cytosol_peptidase_M17.
    InterProi IPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view ]
    Pfami PF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00481. LAMNOPPTDASE.
    PROSITEi PS00631. CYTOSOL_AP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of complete genome sequence of Neorickettsia risticii: causative agent of Potomac horse fever."
      Lin M., Zhang C., Gibson K., Rikihisa Y.
      Nucleic Acids Res. 37:6076-6091(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IllinoisImported.

    Entry informationi

    Entry nameiC6V4W6_NEORI
    AccessioniPrimary (citable) accession number: C6V4W6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 22, 2009
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3