C6V456 (C6V456_NEORI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Bifunctional purine biosynthesis protein PurH EMBL ACT69171.1
EC=2.1.2.3 EMBL ACT69171.1
EC=3.5.4.10 EMBL ACT69171.1

Gene names

Name:	purH EMBL ACT69171.1
Ordered Locus Names:	NRI_0180

Organism

Neorickettsia risticii (strain Illinois) [Complete proteome] [HAMAP] EMBL ACT69171.1

Taxonomic identifier

434131 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Neorickettsia › Ehrlichia risticii

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. SAAS SAAS024051 IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. SAAS SAAS024051
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. SAAS SAAS024051 Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1. SAAS SAAS024051

Ontologies

Keywords
Biological process	Purine biosynthesis SAAS SAAS024051
Molecular function	Hydrolase SAAS SAAS024051 EMBL ACT69171.1 Transferase SAAS SAAS024051 EMBL ACT69171.1
Technical term	Complete proteome Multifunctional enzyme SAAS SAAS024051
Gene Ontology (GO)
Biological_process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	IMP cyclohydrolase activity Inferred from electronic annotation. Source: EC phosphoribosylaminoimidazolecarboxamide formyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C6V456 [UniParc]. Last modified September 22, 2009. Version 1. Checksum: 9B3760CF54C6FDC5	FASTA	490	54,078
	10 20 30 40 50 60 MIKRALISVY DKTDLLPLAY KLQAANVEII ATGKTHQYLL ENQIRATNLS DYTHQPEILG 70 80 90 100 110 120 GRVKTLHPVI HAGLLADPAL HEAEMQTLAI KQIDLVVVNL YPFEKCVNSG APESEIIENI 130 140 150 160 170 180 DIGGVSLLRS AAKNFKNVCV LSDPSDYSTF DVNPTLSFRS KMARKAFARV ARYDCKIAEW 190 200 210 220 230 240 FASSTSLPEV LNLSVMKKND FRYGENPHQN ASFYSDGEFP LTKLQGKELS YNNLLDLDSA 250 260 270 280 290 300 LSIVTNFTEP TCAIIKHTNP CGVASHKSSL EQAYEKALAA DSLSAFGGVV ALNQIVTRNV 310 320 330 340 350 360 AEKLLNTFFE VIVAYGITQD AILLFSNKPN LRVLTYKSYT APEKNMLSLL GGLLVQSGNT 370 380 390 400 410 420 KLFQDFEIVT KRQPTNEELN QLVFAWKICK YVKSNAIVTA HDYTTVGIGA GQMSRVKSVE 430 440 450 460 470 480 IALGKSKVGQ PLAMASDAFF PFADSIELAA KNGVESIIQP GGSIRDKEVI EAANHHNIAM 490 IFTRMRHFRH

References

[1]	"Analysis of complete genome sequence of Neorickettsia risticii: causative agent of Potomac horse fever." Lin M., Zhang C., Gibson K., Rikihisa Y. Nucleic Acids Res. 37:6076-6091(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Illinois.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001431 Genomic DNA. Translation: ACT69171.1.
RefSeq	YP_003081410.1. NC_013009.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	434131.NRI_0180.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACT69171; ACT69171; NRI_0180.
GeneID	8220261.
KEGG	nri:NRI_0180.
PATRIC	22678652. VBINeoRis104330_0169.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0138.
HOGENOM	HOG000230373.
KO	K00602.
OMA	DLLFAWK.
ProtClustDB	CLSK2528115.
Enzyme and pathway databases
BioCyc	NRIS434131:GJCC-182-MONOMER.
UniPathway	UPA00074; UER00133. UPA00074; UER00135.
Family and domain databases
Gene3D	3.40.140.20. 2 hits. 3.40.50.1380. 1 hit.
InterPro	IPR024051. AICAR_Tfase_dom. IPR002695. AICARFT_IMPCHas. IPR016193. Cytidine_deaminase-like. IPR011607. MGS-like_dom. [Graphical view]
PANTHER	PTHR11692. PTHR11692. 1 hit.
Pfam	PF01808. AICARFT_IMPCHas. 1 hit. PF02142. MGS. 1 hit. [Graphical view]
PIRSF	PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMART	SM00798. AICARFT_IMPCHas. 1 hit. SM00851. MGS. 1 hit. [Graphical view]
SUPFAM	SSF53927. Cytidine_deaminase-like. 1 hit. SSF52335. MGS-like_dom. 1 hit.
TIGRFAMs	TIGR00355. purH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C6V456_NEORI

Accession

Primary (citable) accession number: C6V456

Entry history

Integrated into UniProtKB/TrEMBL:	September 22, 2009
Last sequence update:	September 22, 2009
Last modified:	May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)