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C6V456

- C6V456_NEORI

UniProt

C6V456 - C6V456_NEORI

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Neorickettsia risticii (strain Illinois)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation, TransferaseUniRule annotationSAAS annotation

Keywords - Biological processi

Purine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciNRIS434131:GJCC-182-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotationSAAS annotation
Gene namesi
Name:purHUniRule annotationImported
Ordered Locus Names:NRI_0180Imported
OrganismiNeorickettsia risticii (strain Illinois)Imported
Taxonomic identifieri434131 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia
ProteomesiUP000001627: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi434131.NRI_0180.

Structurei

3D structure databases

ProteinModelPortaliC6V456.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

C6V456-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKRALISVY DKTDLLPLAY KLQAANVEII ATGKTHQYLL ENQIRATNLS
60 70 80 90 100
DYTHQPEILG GRVKTLHPVI HAGLLADPAL HEAEMQTLAI KQIDLVVVNL
110 120 130 140 150
YPFEKCVNSG APESEIIENI DIGGVSLLRS AAKNFKNVCV LSDPSDYSTF
160 170 180 190 200
DVNPTLSFRS KMARKAFARV ARYDCKIAEW FASSTSLPEV LNLSVMKKND
210 220 230 240 250
FRYGENPHQN ASFYSDGEFP LTKLQGKELS YNNLLDLDSA LSIVTNFTEP
260 270 280 290 300
TCAIIKHTNP CGVASHKSSL EQAYEKALAA DSLSAFGGVV ALNQIVTRNV
310 320 330 340 350
AEKLLNTFFE VIVAYGITQD AILLFSNKPN LRVLTYKSYT APEKNMLSLL
360 370 380 390 400
GGLLVQSGNT KLFQDFEIVT KRQPTNEELN QLVFAWKICK YVKSNAIVTA
410 420 430 440 450
HDYTTVGIGA GQMSRVKSVE IALGKSKVGQ PLAMASDAFF PFADSIELAA
460 470 480 490
KNGVESIIQP GGSIRDKEVI EAANHHNIAM IFTRMRHFRH
Length:490
Mass (Da):54,078
Last modified:September 22, 2009 - v1
Checksum:i9B3760CF54C6FDC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001431 Genomic DNA. Translation: ACT69171.1.
RefSeqiWP_015816062.1. NC_013009.1.
YP_003081410.1. NC_013009.1.

Genome annotation databases

EnsemblBacteriaiACT69171; ACT69171; NRI_0180.
GeneIDi8220261.
KEGGinri:NRI_0180.
PATRICi22678652. VBINeoRis104330_0169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001431 Genomic DNA. Translation: ACT69171.1 .
RefSeqi WP_015816062.1. NC_013009.1.
YP_003081410.1. NC_013009.1.

3D structure databases

ProteinModelPortali C6V456.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 434131.NRI_0180.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACT69171 ; ACT69171 ; NRI_0180 .
GeneIDi 8220261.
KEGGi nri:NRI_0180.
PATRICi 22678652. VBINeoRis104330_0169.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci NRIS434131:GJCC-182-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Analysis of complete genome sequence of Neorickettsia risticii: causative agent of Potomac horse fever."
    Lin M., Zhang C., Gibson K., Rikihisa Y.
    Nucleic Acids Res. 37:6076-6091(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IllinoisImported.

Entry informationi

Entry nameiC6V456_NEORI
AccessioniPrimary (citable) accession number: C6V456
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: November 26, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported, Multifunctional enzymeUniRule annotationSAAS annotation

External Data

Dasty 3