C6V283 (C6V283_ECO5T) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
6-phosphogluconolactonase HAMAP MF_01605
Short name=6-P-gluconolactonase HAMAP MF_01605
EC=3.1.1.31 HAMAP MF_01605

Gene names

Name:	pgl HAMAP MF_01605 EMBL ACT70679.1
Ordered Locus Names:	ECSP_0820

Organism

Escherichia coli O157:H7 (strain TW14359 / EHEC) [Complete proteome] [HAMAP]

Taxonomic identifier

544404 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate By similarity. HAMAP MF_01605 SAAS SAAS019405
Catalytic activity	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate. HAMAP MF_01605 SAAS SAAS019405
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3. HAMAP MF_01605 SAAS SAAS019405
Sequence similarities	Belongs to the cycloisomerase 2 family. HAMAP MF_01605

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism HAMAP MF_01605 SAAS SAAS019405
Molecular function	Hydrolase HAMAP MF_01605 SAAS SAAS019405
PTM	Acetylation HAMAP MF_01605
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: InterPro
Molecular function	6-phosphogluconolactonase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	287	1	N6-acetyllysine By similarity HAMAP MF_01605

Sequences

	Sequence		Length	Mass (Da)
	C6V283 [UniParc]. Last modified September 22, 2009. Version 1. Checksum: BC4A7F215D231BDE	FASTA	331	36,391
	10 20 30 40 50 60 MKQTVYIASP ESQQIHVWNL NHEGALTLTQ VVDVPGQVQP MVVSPDKRYL YVGVRPEFRV 70 80 90 100 110 120 LAYRIAPDDG ALTFAAESAL PGSPTHISTD HQGQFVFVGS YNAGNVSVTR LEDGLPVGVV 130 140 150 160 170 180 DVVEGLDGCH SANISPDNRT LWVPALKQDR ICLFTVSDDG HLVAQDPAEV TTVEGAGPRH 190 200 210 220 230 240 MVFHPNEQYA YCVNELNSSV DVWELKDPHG NIECVQTLDM MPENFSDTRW AADIHITPDG 250 260 270 280 290 300 RHLYACDRTA SLITVFSVSE DGSVLSKEGF QPTETQPRGF NIDHRGKYLI AAGQKSHHIS 310 320 330 VYEIVGEQGL LHEKGRYAVG QGPMWVVVNA H

References

[1]

"Analysis of the genome of the Escherichia coli O157:H7 2006 spinach-associated outbreak isolate indicates candidate genes that may enhance virulence." Kulasekara B.R., Jacobs M., Zhou Y., Wu Z., Sims E., Saenphimmachak C., Rohmer L., Ritchie J.M., Radey M., McKevitt M., Freeman T.L., Hayden H., Haugen E., Gillett W., Fong C., Chang J., Beskhlebnaya V., Waldor M.K. , Samadpour M., Whittam T.S., Kaul R., Brittnacher M., Miller S.I. Infect. Immun. 77:3713-3721(2009) [PubMed: 19564389] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001368 Genomic DNA. Translation: ACT70679.1.
RefSeq	YP_003076755.1. NC_013008.1.
3D structure databases
ProteinModelPortal	C6V283.
SMR	C6V283. Positions 1-331.
ModBase	Search...
Protein-protein interaction databases
STRING	C6V283.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000168891; EBESCP00000155540; EBESCG00000165230.
GeneID	8215386.
GenomeReviews	Gene locus ECSP_0820 in contig CP001368_GR.
KEGG	etw:ECSP_0820.
PATRIC	18385524. VBIEscCol9396_0826.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000009586.
OMA	CINELNS.
ProtClustDB	PRK11028.
Family and domain databases
HAMAP	MF_01605. 6P_gluconolactonase. [Tree]
InterPro	IPR022528. 6-phosphogluconolactonase_YbhE. IPR019405. Lactonase_7-beta_prop. IPR011045. N2O_reductase_N. IPR015943. WD40/YVTN_repeat-like_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
KO	K07404.
Pfam	PF10282. Lactonase. 1 hit. [Graphical view]
SUPFAM	SSF50974. N2O_reductase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C6V283_ECO5T

Accession

Primary (citable) accession number: C6V283

Entry history

Integrated into UniProtKB/TrEMBL:	September 22, 2009
Last sequence update:	September 22, 2009
Last modified:	December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)