C6UXN4 (C6UXN4_ECO5T) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
L-lactate dehydrogenase, FMN-linked EMBL ACT74324.1

Gene names

Name:	lldD EMBL ACT74324.1
Ordered Locus Names:	ECSP_4602

Organism

Escherichia coli O157:H7 (strain TW14359 / EHEC) [Complete proteome] [HAMAP]

Taxonomic identifier

544404 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+. SAAS SAAS020920
Cofactor	FMN By similarity. SAAS SAAS020920
Sequence similarities	Contains 1 FMN hydroxy acid dehydrogenase domain. SAAS SAAS020920

Ontologies

Keywords
Ligand	FMN SAAS SAAS020920 Flavoprotein SAAS SAAS020920
Molecular function	Oxidoreductase SAAS SAAS020920
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lactate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	FMN binding Inferred from electronic annotation. Source: InterPro L-lactate dehydrogenase (cytochrome) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C6UXN4 [UniParc]. Last modified September 22, 2009. Version 1. Checksum: CA0D8E208613BF83	FASTA	396	42,758
	10 20 30 40 50 60 MIISAASDYR AAAQRILPPF LFHYMDGGAY SEYTLRRNVE DLSEVALRQR ILKNMSDLSL 70 80 90 100 110 120 ETTLFNEKLS MPVALAPVGL CGMYARRGEV QAAKAADAHG IPFTLSTVSV CPIEEVAPAI 130 140 150 160 170 180 KRPMWFQLYV LRDRGFMRNA LERAKAAGCS TLVFTVDMPT PGARYRDAHS GMSGPNAAMR 190 200 210 220 230 240 RYLQAVTHPQ WAWDVGLNGR PHDLGNISAY LGKPTGLEDY IGWLGNNFDP SISWKDLEWI 250 260 270 280 290 300 RDFWDGPMVI KGILDPEDAR DAVRFGADGI VVSNHGGRQL DGVLSSARAL PAIADAVKGD 310 320 330 340 350 360 IAILADSGIR NGLDVVRMIA LGADTVLLGR AFLYALATAG QAGVANLLNL IEKEMKVAMT 370 380 390 LTGAKSISEI TQDSLVQGLG KELPTALAPM AKGNAA

References

[1]

"Analysis of the genome of the Escherichia coli O157:H7 2006 spinach-associated outbreak isolate indicates candidate genes that may enhance virulence." Kulasekara B.R., Jacobs M., Zhou Y., Wu Z., Sims E., Saenphimmachak C., Rohmer L., Ritchie J.M., Radey M., McKevitt M., Freeman T.L., Hayden H., Haugen E., Gillett W., Fong C., Chang J., Beskhlebnaya V., Waldor M.K. , Samadpour M., Whittam T.S., Kaul R., Brittnacher M., Miller S.I. Infect. Immun. 77:3713-3721(2009) [PubMed: 19564389] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001368 Genomic DNA. Translation: ACT74324.1.
RefSeq	YP_003080400.1. NC_013008.1.
3D structure databases
ProteinModelPortal	C6UXN4.
SMR	C6UXN4. Positions 3-377.
ModBase	Search...
Protein-protein interaction databases
STRING	C6UXN4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000167532; EBESCP00000157304; EBESCG00000169416.
GeneID	8219168.
GenomeReviews	Gene locus ECSP_4602 in contig CP001368_GR.
KEGG	etw:ECSP_4602.
PATRIC	18393391. VBIEscCol9396_4684.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000009653.
OMA	IGWLTEN.
ProtClustDB	PRK11197.
Family and domain databases
HAMAP	MF_01559. L_lact_dehydr. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR012133. Alpha-hydoxy_acid_DH_FMN. IPR000262. FMN-dep_DH. IPR008259. FMN_hydac_DH_AS. IPR020920. L-lactate_DHase_cyt. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K00101.
Pfam	PF01070. FMN_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITE	PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit. PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C6UXN4_ECO5T

Accession

Primary (citable) accession number: C6UXN4

Entry history

Integrated into UniProtKB/TrEMBL:	September 22, 2009
Last sequence update:	September 22, 2009
Last modified:	December 14, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)