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C6UX01

- C6UX01_ECO5T

UniProt

C6UX01 - C6UX01_ECO5T

Protein

Phosphoheptose isomerase

Gene

lpcA

Organism
Escherichia coli O157:H7 (strain TW14359 / EHEC)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.UniRule annotationSAAS annotation

    Catalytic activityi

    D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi61 – 611ZincUniRule annotation
    Metal bindingi65 – 651ZincUniRule annotation
    Binding sitei65 – 651SubstrateUniRule annotation
    Binding sitei124 – 1241SubstrateUniRule annotation
    Metal bindingi172 – 1721ZincUniRule annotation
    Binding sitei172 – 1721SubstrateUniRule annotation
    Metal bindingi180 – 1801ZincUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. D-sedoheptulose 7-phosphate isomerase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-glycero-D-manno-heptose 7-phosphate biosynthetic process Source: UniProtKB-UniPathway
    2. lipopolysaccharide core region biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Carbohydrate metabolismUniRule annotationSAAS annotation

    Keywords - Ligandi

    Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciECOL544404:GKCX-254-MONOMER.
    UniPathwayiUPA00041; UER00436.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoheptose isomeraseUniRule annotation (EC:5.3.1.28UniRule annotation)
    Alternative name(s):
    Sedoheptulose 7-phosphate isomeraseUniRule annotation
    Gene namesi
    Name:lpcAImported
    Synonyms:gmhAUniRule annotation
    Ordered Locus Names:ECSP_0254Imported
    OrganismiEscherichia coli O157:H7 (strain TW14359 / EHEC)Imported
    Taxonomic identifieri544404 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000002056: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiC6UX01.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi544404.ECSP_0254.

    Structurei

    3D structure databases

    ProteinModelPortaliC6UX01.
    SMRiC6UX01. Positions 1-192.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 192156SISUniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni52 – 543Substrate bindingUniRule annotation
    Regioni93 – 942Substrate bindingUniRule annotation
    Regioni119 – 1213Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the SIS family. GmhA subfamily.UniRule annotation
    Contains 1 SIS domain.UniRule annotation
    Contains SIS domain.SAAS annotation

    Phylogenomic databases

    eggNOGiCOG0279.
    HOGENOMiHOG000237571.
    KOiK03271.
    OMAiHVFSRYV.
    OrthoDBiEOG6384PC.

    Family and domain databases

    HAMAPiMF_00067. GmhA.
    InterProiIPR004515. Phosphoheptose_Isoase.
    IPR001347. SIS.
    [Graphical view]
    PfamiPF13580. SIS_2. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00441. gmhA. 1 hit.
    PROSITEiPS51464. SIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C6UX01-1 [UniParc]FASTAAdd to Basket

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    MYQDLIRNEL NEAAETLANF LKDDANIHAI QRAAVLLADS FKAGGKVLSC    50
    GNGGSHCDAM HFAEELTGRY RENRPGYPAI AISDVSHISC VGNDFGFNDI 100
    FSRYVEAVGR EGDVLLGIST SGNSANVIKA IAAAREKGMK VITLTGKDGG 150
    KMAGTADIEI RVPHFGYADR IQEIHIKVIH ILIQLIEKEM VK 192
    Length:192
    Mass (Da):20,815
    Last modified:September 22, 2009 - v1
    Checksum:i7A2C05E1079108B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001368 Genomic DNA. Translation: ACT70142.1.
    RefSeqiYP_003076218.1. NC_013008.1.

    Genome annotation databases

    EnsemblBacteriaiACT70142; ACT70142; ECSP_0254.
    GeneIDi8214820.
    KEGGietw:ECSP_0254.
    PATRICi18384342. VBIEscCol9396_0253.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001368 Genomic DNA. Translation: ACT70142.1 .
    RefSeqi YP_003076218.1. NC_013008.1.

    3D structure databases

    ProteinModelPortali C6UX01.
    SMRi C6UX01. Positions 1-192.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 544404.ECSP_0254.

    Proteomic databases

    PRIDEi C6UX01.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACT70142 ; ACT70142 ; ECSP_0254 .
    GeneIDi 8214820.
    KEGGi etw:ECSP_0254.
    PATRICi 18384342. VBIEscCol9396_0253.

    Phylogenomic databases

    eggNOGi COG0279.
    HOGENOMi HOG000237571.
    KOi K03271.
    OMAi HVFSRYV.
    OrthoDBi EOG6384PC.

    Enzyme and pathway databases

    UniPathwayi UPA00041 ; UER00436 .
    BioCyci ECOL544404:GKCX-254-MONOMER.

    Family and domain databases

    HAMAPi MF_00067. GmhA.
    InterProi IPR004515. Phosphoheptose_Isoase.
    IPR001347. SIS.
    [Graphical view ]
    Pfami PF13580. SIS_2. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00441. gmhA. 1 hit.
    PROSITEi PS51464. SIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the genome of the Escherichia coli O157:H7 2006 spinach-associated outbreak isolate indicates candidate genes that may enhance virulence."
      Kulasekara B.R., Jacobs M., Zhou Y., Wu Z., Sims E., Saenphimmachak C., Rohmer L., Ritchie J.M., Radey M., McKevitt M., Freeman T.L., Hayden H., Haugen E., Gillett W., Fong C., Chang J., Beskhlebnaya V., Waldor M.K.
      , Samadpour M., Whittam T.S., Kaul R., Brittnacher M., Miller S.I.
      Infect. Immun. 77:3713-3721(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW14359 / EHECImported.

    Entry informationi

    Entry nameiC6UX01_ECO5T
    AccessioniPrimary (citable) accession number: C6UX01
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 22, 2009
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.UniRule annotation

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3