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C6UX01

- C6UX01_ECO5T

UniProt

C6UX01 - C6UX01_ECO5T

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Protein
Phosphoheptose isomerase
Gene
lpcA, gmhA, ECSP_0254
Organism
Escherichia coli O157:H7 (strain TW14359 / EHEC)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate By similarity.UniRule annotationSAAS annotations

Catalytic activityi

D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.UniRule annotationSAAS annotations

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Zinc By similarityUniRule annotation
Metal bindingi65 – 651Zinc By similarityUniRule annotation
Binding sitei65 – 651Substrate By similarityUniRule annotation
Binding sitei124 – 1241Substrate By similarityUniRule annotation
Metal bindingi172 – 1721Zinc By similarityUniRule annotation
Binding sitei172 – 1721Substrate By similarityUniRule annotation
Metal bindingi180 – 1801Zinc By similarityUniRule annotation

GO - Molecular functioni

  1. D-sedoheptulose 7-phosphate isomerase activity Source: UniProtKB-HAMAP
  2. carbohydrate binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-glycero-D-manno-heptose 7-phosphate biosynthetic process Source: UniProtKB-UniPathway
  2. lipopolysaccharide core region biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Carbohydrate metabolismUniRule annotationSAAS annotations

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotations, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciECOL544404:GKCX-254-MONOMER.
UniPathwayiUPA00041; UER00436.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoheptose isomeraseUniRule annotation (EC:5.3.1.28UniRule annotation)
Alternative name(s):
Sedoheptulose 7-phosphate isomerase
Gene namesi
Name:lpcAImported
Synonyms:gmhAUniRule annotation
Ordered Locus Names:ECSP_0254Imported
OrganismiEscherichia coli O157:H7 (strain TW14359 / EHEC)Imported
Taxonomic identifieri544404 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000002056: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

PTM / Processingi

Proteomic databases

PRIDEiC6UX01.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi544404.ECSP_0254.

Structurei

3D structure databases

ProteinModelPortaliC6UX01.
SMRiC6UX01. Positions 1-192.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 192156SIS By similarityUniRule annotation
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni52 – 543Substrate binding By similarityUniRule annotation
Regioni93 – 942Substrate binding By similarityUniRule annotation
Regioni119 – 1213Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Belongs to the SIS family. GmhA subfamily.UniRule annotation
Contains 1 SIS domain.UniRule annotation
Contains SIS domain.SAAS annotations

Phylogenomic databases

eggNOGiCOG0279.
HOGENOMiHOG000237571.
KOiK03271.
OMAiHVFSRYV.
OrthoDBiEOG6384PC.

Family and domain databases

HAMAPiMF_00067. GmhA.
InterProiIPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
[Graphical view]
PfamiPF13580. SIS_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00441. gmhA. 1 hit.
PROSITEiPS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6UX01-1 [UniParc]FASTAAdd to Basket

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MYQDLIRNEL NEAAETLANF LKDDANIHAI QRAAVLLADS FKAGGKVLSC    50
GNGGSHCDAM HFAEELTGRY RENRPGYPAI AISDVSHISC VGNDFGFNDI 100
FSRYVEAVGR EGDVLLGIST SGNSANVIKA IAAAREKGMK VITLTGKDGG 150
KMAGTADIEI RVPHFGYADR IQEIHIKVIH ILIQLIEKEM VK 192
Length:192
Mass (Da):20,815
Last modified:September 22, 2009 - v1
Checksum:i7A2C05E1079108B4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001368 Genomic DNA. Translation: ACT70142.1.
RefSeqiYP_003076218.1. NC_013008.1.

Genome annotation databases

EnsemblBacteriaiACT70142; ACT70142; ECSP_0254.
GeneIDi8214820.
KEGGietw:ECSP_0254.
PATRICi18384342. VBIEscCol9396_0253.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001368 Genomic DNA. Translation: ACT70142.1 .
RefSeqi YP_003076218.1. NC_013008.1.

3D structure databases

ProteinModelPortali C6UX01.
SMRi C6UX01. Positions 1-192.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 544404.ECSP_0254.

Proteomic databases

PRIDEi C6UX01.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACT70142 ; ACT70142 ; ECSP_0254 .
GeneIDi 8214820.
KEGGi etw:ECSP_0254.
PATRICi 18384342. VBIEscCol9396_0253.

Phylogenomic databases

eggNOGi COG0279.
HOGENOMi HOG000237571.
KOi K03271.
OMAi HVFSRYV.
OrthoDBi EOG6384PC.

Enzyme and pathway databases

UniPathwayi UPA00041 ; UER00436 .
BioCyci ECOL544404:GKCX-254-MONOMER.

Family and domain databases

HAMAPi MF_00067. GmhA.
InterProi IPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
[Graphical view ]
Pfami PF13580. SIS_2. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00441. gmhA. 1 hit.
PROSITEi PS51464. SIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the genome of the Escherichia coli O157:H7 2006 spinach-associated outbreak isolate indicates candidate genes that may enhance virulence."
    Kulasekara B.R., Jacobs M., Zhou Y., Wu Z., Sims E., Saenphimmachak C., Rohmer L., Ritchie J.M., Radey M., McKevitt M., Freeman T.L., Hayden H., Haugen E., Gillett W., Fong C., Chang J., Beskhlebnaya V., Waldor M.K.
    , Samadpour M., Whittam T.S., Kaul R., Brittnacher M., Miller S.I.
    Infect. Immun. 77:3713-3721(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW14359 / EHEC.

Entry informationi

Entry nameiC6UX01_ECO5T
AccessioniPrimary (citable) accession number: C6UX01
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: June 11, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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