Skip Header

Contribute Send feedback
Read comments (?) or add your own

C6USB8 (C6USB8_ECO5T) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
L-fucose isomerase HAMAP-Rule MF_01254
EC=5.3.1.25 HAMAP-Rule MF_01254
Alternative name(s):
6-deoxy-L-galactose isomerase HAMAP-Rule MF_01254
FucIase HAMAP-Rule MF_01254
Gene names
Name:fucI HAMAP-Rule MF_01254 EMBL ACT73504.1
Ordered Locus Names:ECSP_3754 EMBL ACT73504.1
OrganismEscherichia coli O157:H7 (strain TW14359 / EHEC) [Complete proteome] [HAMAP] EMBL ACT73504.1
Taxonomic identifier544404 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length591 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts the aldose L-fucose into the corresponding ketose L-fuculose By similarity. HAMAP-Rule MF_01254

Catalytic activity

L-fucose = L-fuculose. HAMAP-Rule MF_01254 SAAS SAAS012889

Cofactor

Manganese By similarity. HAMAP-Rule MF_01254 SAAS SAAS012889

Pathway

Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3. HAMAP-Rule MF_01254 SAAS SAAS012889

Subunit structure

Homohexamer By similarity. HAMAP-Rule MF_01254

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01254.

Sequence similarities

Belongs to the L-fucose isomerase family. HAMAP-Rule MF_01254

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site3371Proton acceptor By similarity HAMAP-Rule MF_01254
Active site3611Proton acceptor By similarity HAMAP-Rule MF_01254
Metal binding3371Manganese By similarity HAMAP-Rule MF_01254
Metal binding3611Manganese By similarity HAMAP-Rule MF_01254
Metal binding5281Manganese By similarity HAMAP-Rule MF_01254

Sequences

Sequence LengthMass (Da)Tools
C6USB8 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: 0926C070F3851AFE

FASTA59164,963
        10         20         30         40         50         60 
MNKISLPKIG IRPVIDGRRM GVRESLEEQT MNMAKATAAL LTEKLRHACG AAVECVISDT 

        70         80         90        100        110        120 
CIAGMAEAAA CEEKFSSQNV GLTITVTPCW CYGSETIDMD PTRPKAIWGF NGTERPGAVY 

       130        140        150        160        170        180 
LAAALAAHSQ KGIPAFSIYG HDVQDADDTS IPADVEEKLL RFARAGLAVA SMKGKSYLSL 

       190        200        210        220        230        240 
GGVSMGIAGS IVDHNFFESW LGMKVQAVDM TELRRRIDQK IYDEAELEMA LAWADKNFRY 

       250        260        270        280        290        300 
GEDENNKQYQ RNAEQSRAVL RESLLMAMCI RDMMQGNSKL ADIGRVEESL GYNAIAAGFQ 

       310        320        330        340        350        360 
GQRHWTDQYP NGDTAEAILN SSFDWNGVRE PFVVATENDS LNGVAMLMGH QLTGTAQVFA 

       370        380        390        400        410        420 
DVRTYWSPEA IERVTGHKLD GLAEHGIIHL INSGSAALDG SCKQRDSEGN PTMKPHWEIS 

       430        440        450        460        470        480 
QQEADACLAA TEWCPAIHEY FRGGGYSSRF LTEGGVPFTM TRVNIIKGLG PVLQIAEGWS 

       490        500        510        520        530        540 
VELPKDVHDI LNKRTNSTWP TTWFAPRLTG KGPFTDVYSV MANWGANHGV LTIGHVGADF 

       550        560        570        580        590 
ITLASMLRIP VCMHNVEETK VYRPSAWAAH GMDIEGQDYR ACQNYGPLYK R

« Hide

References

[1]"Analysis of the genome of the Escherichia coli O157:H7 2006 spinach-associated outbreak isolate indicates candidate genes that may enhance virulence."
Kulasekara B.R., Jacobs M., Zhou Y., Wu Z., Sims E., Saenphimmachak C., Rohmer L., Ritchie J.M., Radey M., McKevitt M., Freeman T.L., Hayden H., Haugen E., Gillett W., Fong C., Chang J., Beskhlebnaya V., Waldor M.K. expand/collapse author list , Samadpour M., Whittam T.S., Kaul R., Brittnacher M., Miller S.I.
Infect. Immun. 77:3713-3721(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TW14359 / EHEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001368 Genomic DNA. Translation: ACT73504.1.
RefSeqYP_003079580.1. NC_013008.1.

3D structure databases

ProteinModelPortalC6USB8.
SMRC6USB8. Positions 1-591.
ModBaseSearch...

Protein-protein interaction databases

STRING544404.ECSP_3754.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACT73504; ACT73504; ECSP_3754.
GeneID8218320.
KEGGetw:ECSP_3754.
PATRIC18391611. VBIEscCol9396_3811.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2407.
HOGENOMHOG000249674.
KOK01818.
OMAKIGIRPT.
ProtClustDBPRK10991.

Enzyme and pathway databases

BioCycECOL544404:GKCX-3749-MONOMER.
UniPathwayUPA00563; UER00624.

Family and domain databases

Gene3D3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPMF_01254. Fucose_iso.
InterProIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMSSF50443. Fuc_isomerase_C. 1 hit.
SSF53743. Fuc_isomerase_N. 1 hit.
TIGRFAMsTIGR01089. fucI. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC6USB8_ECO5T
AccessionPrimary (citable) accession number: C6USB8
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: May 29, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info