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Protein

tRNA1(Val) (adenine(37)-N6)-methyltransferase

Gene

yfiC

Organism
Escherichia coli O157:H7 (strain TW14359 / EHEC)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the adenine in position 37 of tRNA1(Val) (anticodon cmo5UAC).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + adenine(37) in tRNA1(Val) = S-adenosyl-L-homocysteine + N(6)-methyladenine(37) in tRNA1(Val).UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciECOL544404:GKCX-3517-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA1(Val) (adenine(37)-N6)-methyltransferaseUniRule annotation (EC:2.1.1.223UniRule annotation)
Alternative name(s):
tRNA m6A37 methyltransferaseUniRule annotation
Gene namesi
Name:yfiCUniRule annotation
Ordered Locus Names:ECSP_3521
OrganismiEscherichia coli O157:H7 (strain TW14359 / EHEC)
Taxonomic identifieri544404 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245tRNA1(Val) (adenine(37)-N6)-methyltransferasePRO_0000387368Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliC6UQY1.
SMRiC6UQY1. Positions 10-201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000283147.
KOiK15460.
OMAiDRLFCYH.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01872. tRNA_methyltr_YfiC. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
IPR022882. tRNA_adenine-N6_MeTrfase.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6UQY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSTSVLRR NGFTFKQFFV AHDRCAMKAG TDGILLGAWA PVAGVKRCLD
60 70 80 90 100
IGAGSGLLAL MLAQRTSDSV IIDAVELESE AATQAQENVA QSPWLERINV
110 120 130 140 150
HTADIQQWVT QQTARFDLII SNPPYYEQGV ECATPQREQA RYTTSLDHQT
160 170 180 190 200
LLTCAAECIT EEGFFCVVLP EQIGNSFTEL ALSMGWHLRL RTDVAENEAR
210 220 230 240
LPHRVLLAFS PQAGECFSDR LVIRGPDQNY SEAYTALTQA FYLFM
Length:245
Mass (Da):27,215
Last modified:September 22, 2009 - v1
Checksum:i4E79CA35A7CE03EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001368 Genomic DNA. Translation: ACT73287.1.
RefSeqiWP_000083666.1. NC_013008.1.

Genome annotation databases

EnsemblBacteriaiACT73287; ACT73287; ECSP_3521.
KEGGietw:ECSP_3521.
PATRICi18391124. VBIEscCol9396_3579.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001368 Genomic DNA. Translation: ACT73287.1.
RefSeqiWP_000083666.1. NC_013008.1.

3D structure databases

ProteinModelPortaliC6UQY1.
SMRiC6UQY1. Positions 10-201.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACT73287; ACT73287; ECSP_3521.
KEGGietw:ECSP_3521.
PATRICi18391124. VBIEscCol9396_3579.

Phylogenomic databases

HOGENOMiHOG000283147.
KOiK15460.
OMAiDRLFCYH.

Enzyme and pathway databases

BioCyciECOL544404:GKCX-3517-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01872. tRNA_methyltr_YfiC. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
IPR022882. tRNA_adenine-N6_MeTrfase.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRMN6_ECO5T
AccessioniPrimary (citable) accession number: C6UQY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: September 22, 2009
Last modified: September 7, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.