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C6UQM6 (C6UQM6_ECO5T) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP-Rule MF_00137 RuleBase RU000613
EC=6.3.2.6 HAMAP-Rule MF_00137 RuleBase RU000613
Alternative name(s):
SAICAR synthetase HAMAP-Rule MF_00137
Gene names
Name:purC HAMAP-Rule MF_00137 EMBL ACT73182.1
Ordered Locus Names:ECSP_3415 EMBL ACT73182.1
OrganismEscherichia coli O157:H7 (strain TW14359 / EHEC) [Complete proteome] [HAMAP] EMBL ACT73182.1
Taxonomic identifier544404 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length237 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP-Rule MF_00137 RuleBase RU000613 SAAS SAAS018236

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP-Rule MF_00137 RuleBase RU000613 SAAS SAAS018236

Sequence similarities

Belongs to the SAICAR synthetase family. HAMAP-Rule MF_00137 RuleBase RU004193

Sequences

Sequence LengthMass (Da)Tools
C6UQM6 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: E5D0E69E84E35C97

FASTA23726,995
        10         20         30         40         50         60 
MQKQAELYRG KAKTVYSTEN PDLLVLEFRN DTSAGDGARI EQFDRKGMVN NKFNYFIMSK 

        70         80         90        100        110        120 
LAEAGIPTQM ERLLSDTECL VKKLDMVPVE CVVRNRAAGS LVKRLGIEEG IELNPPLFDL 

       130        140        150        160        170        180 
FLKNDAMHDP MVNESYCETF GWVSKENLAR MKELTYKAND VLKKLFDDAG LILVDFKLEF 

       190        200        210        220        230 
GLYKGEVVLG DEFSPDGSRL WDKETLEKMD KDRFRQSLGG LIEAYEAVAR RLGVQLD

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References

[1]"Analysis of the genome of the Escherichia coli O157:H7 2006 spinach-associated outbreak isolate indicates candidate genes that may enhance virulence."
Kulasekara B.R., Jacobs M., Zhou Y., Wu Z., Sims E., Saenphimmachak C., Rohmer L., Ritchie J.M., Radey M., McKevitt M., Freeman T.L., Hayden H., Haugen E., Gillett W., Fong C., Chang J., Beskhlebnaya V., Waldor M.K. expand/collapse author list , Samadpour M., Whittam T.S., Kaul R., Brittnacher M., Miller S.I.
Infect. Immun. 77:3713-3721(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TW14359 / EHEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001368 Genomic DNA. Translation: ACT73182.1.
RefSeqYP_003079258.1. NC_013008.1.

3D structure databases

ProteinModelPortalC6UQM6.
SMRC6UQM6. Positions 1-237.
ModBaseSearch...

Protein-protein interaction databases

STRING544404.ECSP_3415.

Proteomic databases

PRIDEC6UQM6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACT73182; ACT73182; ECSP_3415.
GeneID8217981.
KEGGetw:ECSP_3415.
PATRIC18390904. VBIEscCol9396_3469.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0152.
HOGENOMHOG000082629.
KOK01923.
OMAVQYFKDD.
ProtClustDBPRK09362.

Enzyme and pathway databases

BioCycECOL544404:GKCX-3411-MONOMER.
UniPathwayUPA00074; UER00131.

Family and domain databases

Gene3D3.30.470.20. 1 hit.
HAMAPMF_00137. SAICAR_synth.
InterProIPR013816. ATP_grasp_subdomain_2.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
PANTHERPTHR11609. PTHR11609. 1 hit.
PfamPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsTIGR00081. purC. 1 hit.
PROSITEPS01057. SAICAR_SYNTHETASE_1. 1 hit.
PS01058. SAICAR_SYNTHETASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC6UQM6_ECO5T
AccessionPrimary (citable) accession number: C6UQM6
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: May 29, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info