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C6UQ52

- C6UQ52_ECO5T

UniProt

C6UQ52 - C6UQ52_ECO5T

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Protein
Succinyl-diaminopimelate desuccinylase
Gene
dapE, ECSP_3410
Organism
Escherichia coli O157:H7 (strain TW14359 / EHEC)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls By similarity.UniRule annotationSAAS annotations

Catalytic activityi

N-succinyl-LL-2,6-diaminoheptanedioate + H2O = succinate + LL-2,6-diaminoheptanedioate.UniRule annotationSAAS annotations

Cofactori

Binds 1 Co2+ ion per subunit By similarity.UniRule annotationSAAS annotations
Binds 1 Zn2+ ion per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi66 – 661Cobalt or zinc 1 By similarityUniRule annotation
Active sitei68 – 681 By similarityUniRule annotation
Metal bindingi99 – 991Cobalt or zinc 1 By similarityUniRule annotation
Metal bindingi99 – 991Cobalt or zinc 2 By similarityUniRule annotation
Active sitei133 – 1331Proton acceptor By similarityUniRule annotation
Metal bindingi134 – 1341Cobalt or zinc 2 By similarityUniRule annotation
Metal bindingi162 – 1621Cobalt or zinc 1 By similarityUniRule annotation
Metal bindingi348 – 3481Cobalt or zinc 2 By similarityUniRule annotation

GO - Molecular functioni

  1. cobalt ion binding Source: UniProtKB-HAMAP
  2. metallopeptidase activity Source: InterPro
  3. succinyl-diaminopimelate desuccinylase activity Source: UniProtKB-HAMAP
  4. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
  2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotations

Keywords - Biological processi

Amino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotationSAAS annotations, Lysine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

CobaltUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciECOL544404:GKCX-3406-MONOMER.
UniPathwayiUPA00034; UER00021.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinyl-diaminopimelate desuccinylaseUniRule annotation (EC:3.5.1.18UniRule annotation)
Short name:
SDAP desuccinylaseUniRule annotation
Alternative name(s):
N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase
Gene namesi
Name:dapEUniRule annotationImported
Ordered Locus Names:ECSP_3410Imported
OrganismiEscherichia coli O157:H7 (strain TW14359 / EHEC)Imported
Taxonomic identifieri544404 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000002056: Chromosome

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi544404.ECSP_3410.

Structurei

3D structure databases

ProteinModelPortaliC6UQ52.
SMRiC6UQ52. Positions 2-374.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20A family. DapE subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0624.
HOGENOMiHOG000243770.
KOiK01439.
OMAiHAGRLAF.
OrthoDBiEOG60651W.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_01690. DapE.
InterProiIPR001261. ArgE/DapE_CS.
IPR005941. DapE_proteobac.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01246. dapE_proteo. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6UQ52-1 [UniParc]FASTAAdd to Basket

« Hide

MSCPVIELTQ QLIRRPSLSP DDAGCQALLI ERLQAIGFTV ERMDFADTQN    50
FWAWRGQGET LAFAGHTDVV PPGDADRWIN PPFEPTIRDG MLFGRGAADM 100
KGSLAAMVVA AERFVAQHPN HTGRLAFLIT SDEEASAHNG TVKAVEALMA 150
RNERLDYCLV GEPSSIEVVG DVVKNGRRGS LTCNLTIHGV QGHVAYPHLA 200
DNPVHRAAPF LNELVAIEWD QGNEFFPATS MQIANIQAGT GSNNVIPGEL 250
FVQFNFRFST ELTDEMIKAQ VLALLEKHQL RYTVDWWLSG QPFLTARGKL 300
VDAVVNAVEH YNEIKPQLLT TGGTSDGRFI ARMGAQVVEL GPVNATIHKI 350
NECVNAADLQ LLARMYQRIM EQLVA 375
Length:375
Mass (Da):41,241
Last modified:September 22, 2009 - v1
Checksum:iB249E6B09D84F2CA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001368 Genomic DNA. Translation: ACT73177.1.
RefSeqiYP_003079253.1. NC_013008.1.

Genome annotation databases

EnsemblBacteriaiACT73177; ACT73177; ECSP_3410.
GeneIDi8217976.
KEGGietw:ECSP_3410.
PATRICi18390894. VBIEscCol9396_3464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001368 Genomic DNA. Translation: ACT73177.1 .
RefSeqi YP_003079253.1. NC_013008.1.

3D structure databases

ProteinModelPortali C6UQ52.
SMRi C6UQ52. Positions 2-374.
ModBasei Search...

Protein-protein interaction databases

STRINGi 544404.ECSP_3410.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACT73177 ; ACT73177 ; ECSP_3410 .
GeneIDi 8217976.
KEGGi etw:ECSP_3410.
PATRICi 18390894. VBIEscCol9396_3464.

Phylogenomic databases

eggNOGi COG0624.
HOGENOMi HOG000243770.
KOi K01439.
OMAi HAGRLAF.
OrthoDBi EOG60651W.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00021 .
BioCyci ECOL544404:GKCX-3406-MONOMER.

Family and domain databases

Gene3Di 3.30.70.360. 1 hit.
HAMAPi MF_01690. DapE.
InterProi IPR001261. ArgE/DapE_CS.
IPR005941. DapE_proteobac.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view ]
Pfami PF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view ]
SUPFAMi SSF55031. SSF55031. 1 hit.
TIGRFAMsi TIGR01246. dapE_proteo. 1 hit.
PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the genome of the Escherichia coli O157:H7 2006 spinach-associated outbreak isolate indicates candidate genes that may enhance virulence."
    Kulasekara B.R., Jacobs M., Zhou Y., Wu Z., Sims E., Saenphimmachak C., Rohmer L., Ritchie J.M., Radey M., McKevitt M., Freeman T.L., Hayden H., Haugen E., Gillett W., Fong C., Chang J., Beskhlebnaya V., Waldor M.K.
    , Samadpour M., Whittam T.S., Kaul R., Brittnacher M., Miller S.I.
    Infect. Immun. 77:3713-3721(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW14359 / EHEC.

Entry informationi

Entry nameiC6UQ52_ECO5T
AccessioniPrimary (citable) accession number: C6UQ52
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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