C6UPY6 (C6UPY6_ECO5T) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Glucokinase HAMAP-Rule MF_00524
EC=2.7.1.2 HAMAP-Rule MF_00524

Alternative name(s):
Glucose kinase HAMAP-Rule MF_00524

Gene names

Name:	glk HAMAP-Rule MF_00524 EMBL ACT73111.1
Ordered Locus Names:	ECSP_3338 EMBL ACT73111.1

Organism

Escherichia coli O157:H7 (strain TW14359 / EHEC) [Complete proteome] [HAMAP] EMBL ACT73111.1

Taxonomic identifier

544404 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli › Escherichia coli O157:H7

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-glucose = ADP + D-glucose 6-phosphate. HAMAP-Rule MF_00524
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00524.
Sequence similarities	Belongs to the bacterial glucokinase family. RuleBase RU004046 HAMAP-Rule MF_00524

Ontologies

Keywords
Biological process	Glycolysis HAMAP-Rule MF_00524
Cellular component	Cytoplasm HAMAP-Rule MF_00524
Ligand	ATP-binding HAMAP-Rule MF_00524 SAAS SAAS003836 Nucleotide-binding
Molecular function	Kinase HAMAP-Rule MF_00524 SAAS SAAS003836 EMBL ACT73111.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP glucokinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	8 – 13	6	ATP By similarity HAMAP-Rule MF_00524

Sequences

	Sequence		Length	Mass (Da)
	C6UPY6 [UniParc]. Last modified September 22, 2009. Version 1. Checksum: 2D6CD956641A3823	FASTA	321	34,723
	10 20 30 40 50 60 MTKYALVGDV GGTNARLALC DIASGEISQA KTYSGLDYPS LEAVIRVYLE EHKVEVKDGC 70 80 90 100 110 120 IAIACPITGD WVAMTNHTWA FSIAEMKKNL GFSHLEIIND FTAVSMAIPM LKKEHLIQFG 130 140 150 160 170 180 GAEPVEGKPI AVYGAGTGLG VAHLVHVDKR WVSLPGEGGH VDFAPNSEEE AIILEILRAE 190 200 210 220 230 240 IGHVSAERVL SGPGLVNLYR AIVKADNRLP ENLKPKDITE RALADSCTDC RRALSLFCVI 250 260 270 280 290 300 MGRFGGNLAL NLGTFGGVFI AGGIVPRFLE FFKASGFRAA FEDKGRFKEY VHDIPVYLIV 310 320 HDNPGLLGSG AHLRQTLGHI L

References

[1]

"Analysis of the genome of the Escherichia coli O157:H7 2006 spinach-associated outbreak isolate indicates candidate genes that may enhance virulence." Kulasekara B.R., Jacobs M., Zhou Y., Wu Z., Sims E., Saenphimmachak C., Rohmer L., Ritchie J.M., Radey M., McKevitt M., Freeman T.L., Hayden H., Haugen E., Gillett W., Fong C., Chang J., Beskhlebnaya V., Waldor M.K. , Samadpour M., Whittam T.S., Kaul R., Brittnacher M., Miller S.I. Infect. Immun. 77:3713-3721(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW14359 / EHEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001368 Genomic DNA. Translation: ACT73111.1.
RefSeq	YP_003079187.1. NC_013008.1.
3D structure databases
ProteinModelPortal	C6UPY6.
SMR	C6UPY6. Positions 2-321.
ModBase	Search...
Protein-protein interaction databases
STRING	544404.ECSP_3338. C6UPY6.
Proteomic databases
PRIDE	C6UPY6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACT73111; ACT73111; ECSP_3338.
GeneID	8217904.
KEGG	etw:ECSP_3338.
PATRIC	18390746. VBIEscCol9396_3396.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0837.
HOGENOM	HOG000274469.
KO	K00845.
OMA	EAVIRHY.
ProtClustDB	PRK00292.
Family and domain databases
HAMAP	MF_00524. Glucokinase.
InterPro	IPR003836. Glucokinase. [Graphical view]
Pfam	PF02685. Glucokinase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00749. glk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C6UPY6_ECO5T

Accession

Primary (citable) accession number: C6UPY6

Entry history

Integrated into UniProtKB/TrEMBL:	September 22, 2009
Last sequence update:	September 22, 2009
Last modified:	May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)