C6UGC6 (C6UGC6_ECOBR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase EMBL ACT38914.1
EC=2.4.2.18 EMBL ACT38914.1
EC=4.1.3.27 EMBL ACT38914.1

Gene names

Name:	trpD EMBL ACT38914.1
Ordered Locus Names:	ECB_01237

Organism

Escherichia coli (strain B / REL606) [Complete proteome] [HAMAP] EMBL ACT38914.1

Taxonomic identifier

413997 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli › Escherichia coli B

Protein attributes

Sequence length	531 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate. SAAS SAAS005940
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5. SAAS SAAS005940

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis SAAS SAAS005940
Molecular function	Glycosyltransferase SAAS SAAS005940 EMBL ACT38914.1 Lyase EMBL ACT38914.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	anthranilate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP lyase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C6UGC6 [UniParc]. Last modified September 22, 2009. Version 1. Checksum: 10B02E455194F072	FASTA	531	56,870
	10 20 30 40 50 60 MADILLLDNI DSFTYNLADQ LRSNGHNVVI YRNHIPAQTL IERLATMSNP VLMLSPGPGV 70 80 90 100 110 120 PSEAGCMPEL LTRLRGKLPI IGICLGHQAI VEAYGGYVGQ AGEILHGKAS SIEHDGQAMF 130 140 150 160 170 180 AGLTNPLPVA RYHSLVGSNI PAGLTINAHF NGMVMAVRHD ADRVCGFQFH PESILTTQGA 190 200 210 220 230 240 RLLEQTLAWA QQKLEPANTL QPILEKLYQA QTLSQQESHQ LFSAVVRGEL KPEQLAAALV 250 260 270 280 290 300 SMKIRGEHPN EIAGAATALL ENAAPFPRPD YLFADIVGTG GDGSNSINIS TASAFVAAAC 310 320 330 340 350 360 GLKVAKHGNR SVSSKSGSSD LLAAFGINLD MNADKSRQAL DELGVCFLFA PKYHTGFRHA 370 380 390 400 410 420 MPVRQQLKTR TLFNVLGPLI NPAHPPLALI GVYSPELVLP IAETLRVLGY QRAAVVHSGG 430 440 450 460 470 480 MDEVSLHAPT IVAELHDGEI KSYQLTAEDF GLTPYHQEQL AGGTPEENRD ILTRLLQGKG 490 500 510 520 530 DAAHEAAVAA NVAMLMRLHG HEDLQANAQT VLEVLRSGSA YDRVTALAAR G

References

[1]

"Genome sequences of Escherichia coli B strains REL606 and BL21(DE3)." Jeong H., Barbe V., Lee C.H., Vallenet D., Yu D.S., Choi S.H., Couloux A., Lee S.W., Yoon S.H., Cattolico L., Hur C.G., Park H.S., Segurens B., Kim S.C., Oh T.K., Lenski R.E., Studier F.W., Daegelen P., Kim J.F. J. Mol. Biol. 394:644-652(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: B / REL606.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000819 Genomic DNA. Translation: ACT38914.1.
RefSeq	YP_003044450.1. NC_012967.1.
3D structure databases
ProteinModelPortal	C6UGC6.
SMR	C6UGC6. Positions 2-193, 199-530.
ModBase	Search...
Protein-protein interaction databases
STRING	413997.ECB_01237. C6UGC6.
Proteomic databases
PRIDE	C6UGC6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACT38914; ACT38914; ECB_01237.
GeneID	8175961.
KEGG	ebr:ECB_01237.
PATRIC	18234543. VBIEscCol118196_1303.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0547.
HOGENOM	HOG000230451.
KO	K13497.
OMA	GPKHPKD.
ProtClustDB	PRK09522.
Enzyme and pathway databases
UniPathway	UPA00035; UER00041.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit.
HAMAP	MF_00211. TrpD.
InterPro	IPR005940. Anthranilate_Pribosyl_Tfrase. IPR017926. GATASE_1. IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR006221. TrpG/PapA. [Graphical view]
Pfam	PF00117. GATase. 1 hit. PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit.
TIGRFAMs	TIGR01245. trpD. 1 hit. TIGR00566. trpG_papA. 1 hit.
PROSITE	PS51273. GATASE_TYPE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C6UGC6_ECOBR

Accession

Primary (citable) accession number: C6UGC6

Entry history

Integrated into UniProtKB/TrEMBL:	September 22, 2009
Last sequence update:	September 22, 2009
Last modified:	May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)