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C6UBQ2

- C6UBQ2_ECOBR

UniProt

C6UBQ2 - C6UBQ2_ECOBR

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Protein
ATP-dependent Clp protease proteolytic subunit
Gene
clpP, ECB_00388
Organism
Escherichia coli (strain B / REL606)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation
Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu-and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei111 – 1111Nucleophile By similarityUniRule annotation
Active sitei136 – 1361 By similarityUniRule annotation

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotation

Enzyme and pathway databases

BioCyciECOL413997:GCQD-574-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunitUniRule annotation (EC:3.4.21.92UniRule annotation)
Alternative name(s):
Endopeptidase Clp
Gene namesi
Name:clpPUniRule annotationImported
Ordered Locus Names:ECB_00388Imported
OrganismiEscherichia coli (strain B / REL606)Imported
Taxonomic identifieri413997 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001632: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiC6UBQ2.

Interactioni

Subunit structurei

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. Component of the ClpAP and ClpXP complexes By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi413997.ECB_00388.

Structurei

3D structure databases

ProteinModelPortaliC6UBQ2.
SMRiC6UBQ2. Positions 16-207.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0740.
HOGENOMiHOG000285833.
KOiK01358.
OMAiKGERSFD.
OrthoDBiEOG6Z3KQ0.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_00444. ClpP.
InterProiIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view]
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00493. clpP. 1 hit.
PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6UBQ2-1 [UniParc]FASTAAdd to Basket

« Hide

MSYSGERDNF APHMALVPMV IEQTSRGERS FDIYSRLLKE RVIFLTGQVE    50
DHMANLIVAQ MLFLEAENPE KDIYLYINSP GGVITAGMSI YDTMQFIKPD 100
VSTICMGQAA SMGAFLLTAG AKGKRFCLPN SRVMIHQPLG GYQGQATDIE 150
IHAREILKVK GRMNELMALH TGQSLEQIER DTERDRFLSA PEAVEYGLVD 200
SILTHRN 207
Length:207
Mass (Da):23,187
Last modified:September 22, 2009 - v1
Checksum:iA7843D036C8CB3C2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000819 Genomic DNA. Translation: ACT38078.1.
RefSeqiYP_003043614.1. NC_012967.1.

Genome annotation databases

EnsemblBacteriaiACT38078; ACT38078; ECB_00388.
GeneIDi8175309.
KEGGiebr:ECB_00388.
PATRICi18232732. VBIEscCol118196_0418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000819 Genomic DNA. Translation: ACT38078.1 .
RefSeqi YP_003043614.1. NC_012967.1.

3D structure databases

ProteinModelPortali C6UBQ2.
SMRi C6UBQ2. Positions 16-207.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 413997.ECB_00388.

Proteomic databases

PRIDEi C6UBQ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACT38078 ; ACT38078 ; ECB_00388 .
GeneIDi 8175309.
KEGGi ebr:ECB_00388.
PATRICi 18232732. VBIEscCol118196_0418.

Phylogenomic databases

eggNOGi COG0740.
HOGENOMi HOG000285833.
KOi K01358.
OMAi KGERSFD.
OrthoDBi EOG6Z3KQ0.

Enzyme and pathway databases

BioCyci ECOL413997:GCQD-574-MONOMER.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
HAMAPi MF_00444. ClpP.
InterProi IPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view ]
PANTHERi PTHR10381. PTHR10381. 1 hit.
Pfami PF00574. CLP_protease. 1 hit.
[Graphical view ]
PRINTSi PR00127. CLPPROTEASEP.
SUPFAMi SSF52096. SSF52096. 1 hit.
TIGRFAMsi TIGR00493. clpP. 1 hit.
PROSITEi PS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B / REL606.

Entry informationi

Entry nameiC6UBQ2_ECOBR
AccessioniPrimary (citable) accession number: C6UBQ2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: July 9, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi