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Protein

Phosphoenolpyruvate carboxylase

Gene

capP

Organism
Streptococcus mutans serotype c (strain NN2025)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381UniRule annotation
Active sitei570 – 5701UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciSMUT511691:GH9C-1347-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:capPImported
Synonyms:ppcUniRule annotationImported
Ordered Locus Names:SmuNN2025_1290Imported
OrganismiStreptococcus mutans serotype c (strain NN2025)Imported
Taxonomic identifieri511691 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000007704: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6SRH4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTINKLESRN DKEAIAEEIT ILTKLLDDAT KTMVGSASFD KITLFKKLSI
60 70 80 90 100
EEKHQELERE IEQLTNEEMV VVSRYFSILP LLINISEDVN LAYEINYQNN
110 120 130 140 150
NDIDYLGKLS ATIELVSSQK NAQEILENVN VVPVLTAHPT QVQRKTMLDL
160 170 180 190 200
TNHIHELLRK YRDVKAGSIN KQKWYDDMRR YVELIMQTDI IREKKLKVTN
210 220 230 240 250
EITNVMEYYN SSLIKGVTKL ITEYKHLSQQ KGFDLGNAKP ITMGMWIGGD
260 270 280 290 300
RDGNPFVTAE TLKISALVQN EVILNYYIDK VSDLYRTFSL STSLSTISNA
310 320 330 340 350
VKEMADRSTD VSIYREKEPY RKAFHYIQSR LQETLIYLKN NHLEELESED
360 370 380 390 400
SAQILPYQSA QEFRNDLQLI KDSLLENNGS AFITGDLTEL LQAVDVFGFF
410 420 430 440 450
LASIDMRQDS SVHETCVAEL LASANIVANY SDLPEEEKIA ILLKELTEDP
460 470 480 490 500
RILSATHVEK SEILQKELAI FKTARKLKDA LGEDVIKQHI ISHTESISDM
510 520 530 540 550
FELAIMLKEV GLVDTDKARV QIVPLFETIE DLDNSREIMR QYLNYDIVKK
560 570 580 590 600
WIAANHNYQE IMLGYSDSNK DGGYLSSGWA LYKAQNELTE IGSDNGVKIT
610 620 630 640 650
FFHGRGGTVG RGGGPSYEAI TSQPFGSIKD RIRLTEQGEV IGNKYGNKDV
660 670 680 690 700
AYYNLEMLVS ATLDRMVTRR IVNSDNLVNY RLIMDEIVAD SNLIYRDLVF
710 720 730 740 750
GNEHFYDYFF AASPIREVSS LNIGSRPAAR KTITEISGLR AIPWVFSWSQ
760 770 780 790 800
NRIMFPGWYG VGSAFKHFID KDEKNLTKLQ EMYQSWPFFH SLLSNVDMVL
810 820 830 840 850
SKSNMNIAFE YAKLCQDEET KEVFATILDE WQLTKNVILA IESHKQLLED
860 870 880 890 900
NSYLKASLDY RLPYFNVLNY IQIELIKRQR RGELGENLEN LIHITINGVA

TGLRNSG
Length:907
Mass (Da):103,811
Last modified:September 22, 2009 - v1
Checksum:iBA47012853C79E03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010655 Genomic DNA. Translation: BAH88316.1.
RefSeqiYP_003485208.1. NC_013928.1.

Genome annotation databases

EnsemblBacteriaiBAH88316; BAH88316; SmuNN2025_1290.
GeneIDi8835706.
KEGGismc:SmuNN2025_1290.
PATRICi35314476. VBIStrMut11111_1290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010655 Genomic DNA. Translation: BAH88316.1.
RefSeqiYP_003485208.1. NC_013928.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAH88316; BAH88316; SmuNN2025_1290.
GeneIDi8835706.
KEGGismc:SmuNN2025_1290.
PATRICi35314476. VBIStrMut11111_1290.

Phylogenomic databases

HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.

Enzyme and pathway databases

BioCyciSMUT511691:GH9C-1347-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content."
    Maruyama F., Kobata M., Kurokawa K., Nishida K., Sakurai A., Nakano K., Nomura R., Kawabata S., Ooshima T., Nakai K., Hattori M., Hamada S., Nakagawa I.
    BMC Genomics 10:358-358(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NN2025Imported.

Entry informationi

Entry nameiC6SRH4_STRMN
AccessioniPrimary (citable) accession number: C6SRH4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: February 4, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.