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C6SRH2

- C6SRH2_STRMN

UniProt

C6SRH2 - C6SRH2_STRMN

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Protein

Elongation factor Tu

Gene

tuf

Organism
Streptococcus mutans serotype c (strain NN2025)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTPUniRule annotation
Nucleotide bindingi84 – 885GTPUniRule annotation
Nucleotide bindingi139 – 1424GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-HAMAP
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factorUniRule annotation

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMUT511691:GH9C-1345-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor TuUniRule annotation
Short name:
EF-TuUniRule annotation
Gene namesi
Name:tufUniRule annotationImported
Ordered Locus Names:SmuNN2025_1288Imported
OrganismiStreptococcus mutans serotype c (strain NN2025)Imported
Taxonomic identifieri511691 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000007704: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiC6SRH2.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC6SRH2.
SMRiC6SRH2. Positions 2-396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229290.
KOiK02358.
OMAiGTEMCMP.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6SRH2-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MAKEKYDRSK PHVNIGTIGH VDHGKTTLTA AITTVLARRL PSAVNQPKDY
60 70 80 90 100
SSIDAAPEER ERGITINTAH VEYETEKRHY AHIDAPGHAD YVKNMITGAA
110 120 130 140 150
QMDGAILVVA STDGPMPQTR EHILLSRQVG VKYLIVFMNK VDLVDDEELL
160 170 180 190 200
ELVEMEIRDL LSEYDFPGDD IPVIQGSALK ALEGDTAQED IIMELMHTVD
210 220 230 240 250
DYIPDPERDT DKPLLLPVED VFSITGRGTV ASGRIDRGTV KVNDEVEIVG
260 270 280 290 300
IRDDIQKAVV TGVEMFRKQL DEGIAGDNVG VLLRGIQRDE IERGQVLAKP
310 320 330 340 350
GSIHPHTKFK GEVYILTKEE GGRHTPFFNN YRPQFYFRTT DVTGSIELPA
360 370 380 390
GTEMVMPGDN VTIDVELIHP IAVEQGTTFS IREGGRTVGS GIVSEIEA
Length:398
Mass (Da):43,919
Last modified:September 22, 2009 - v1
Checksum:i660548E674C6DF9D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP010655 Genomic DNA. Translation: BAH88314.1.
RefSeqiYP_003485206.1. NC_013928.1.

Genome annotation databases

EnsemblBacteriaiBAH88314; BAH88314; SmuNN2025_1288.
GeneIDi8835017.
KEGGismc:SmuNN2025_1288.
PATRICi35314472. VBIStrMut11111_1288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP010655 Genomic DNA. Translation: BAH88314.1 .
RefSeqi YP_003485206.1. NC_013928.1.

3D structure databases

ProteinModelPortali C6SRH2.
SMRi C6SRH2. Positions 2-396.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi C6SRH2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH88314 ; BAH88314 ; SmuNN2025_1288 .
GeneIDi 8835017.
KEGGi smc:SmuNN2025_1288.
PATRICi 35314472. VBIStrMut11111_1288.

Phylogenomic databases

HOGENOMi HOG000229290.
KOi K02358.
OMAi GTEMCMP.

Enzyme and pathway databases

BioCyci SMUT511691:GH9C-1345-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00118_B. EF_Tu_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view ]
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS00301. EFACTOR_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content."
    Maruyama F., Kobata M., Kurokawa K., Nishida K., Sakurai A., Nakano K., Nomura R., Kawabata S., Ooshima T., Nakai K., Hattori M., Hamada S., Nakagawa I.
    BMC Genomics 10:358-358(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NN2025Imported.

Entry informationi

Entry nameiC6SRH2_STRMN
AccessioniPrimary (citable) accession number: C6SRH2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3