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C6SQI4

- C6SQI4_STRMN

UniProt

C6SQI4 - C6SQI4_STRMN

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Protein

Thymidine kinase

Gene
kitH, tdk, SmuNN2025_0950
Organism
Streptococcus mutans serotype c (strain NN2025)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei101 – 1011Proton acceptor By similarityUniRule annotation
Metal bindingi158 – 1581Zinc By similarityUniRule annotation
Metal bindingi161 – 1611Zinc By similarityUniRule annotation
Metal bindingi195 – 1951Zinc By similarityUniRule annotation
Metal bindingi198 – 1981Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318ATP By similarityUniRule annotation
Nucleotide bindingi100 – 1034ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciSMUT511691:GH9C-1007-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:kitHImported
Synonyms:tdkUniRule annotationImported
Ordered Locus Names:SmuNN2025_0950Imported
OrganismiStreptococcus mutans serotype c (strain NN2025)Imported
Taxonomic identifieri511691 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000007704: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliC6SQI4.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiELKTVCH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6SQI4-1 [UniParc]FASTAAdd to Basket

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MVKWIRYQFE MGMTVLAQLY YKYGTMNSGK TIEILKVAHN YEERGKPVVI    50
MTSSLDTRDG FGVVASRIGM RREAVTITDD MDIFAYIENM FKKPYCILID 100
ESQFLSQKNV YDLARIVDEL DVPVMAFGLK NDFQNHLFEG SRELLLLADK 150
IEEIKTICQF CSKKATMVLR TENGRPVYKG NQIQIGGNET YIPVCRRHYF 200
HPPIKA 206
Length:206
Mass (Da):23,829
Last modified:September 22, 2009 - v1
Checksum:iFB925BF36118A5B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP010655 Genomic DNA. Translation: BAH87976.1.
RefSeqiYP_003484868.1. NC_013928.1.

Genome annotation databases

EnsemblBacteriaiBAH87976; BAH87976; SmuNN2025_0950.
GeneIDi8834796.
KEGGismc:SmuNN2025_0950.
PATRICi35313778. VBIStrMut11111_0941.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP010655 Genomic DNA. Translation: BAH87976.1 .
RefSeqi YP_003484868.1. NC_013928.1.

3D structure databases

ProteinModelPortali C6SQI4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH87976 ; BAH87976 ; SmuNN2025_0950 .
GeneIDi 8834796.
KEGGi smc:SmuNN2025_0950.
PATRICi 35313778. VBIStrMut11111_0941.

Phylogenomic databases

HOGENOMi HOG000076391.
KOi K00857.
OMAi ELKTVCH.

Enzyme and pathway databases

BioCyci SMUT511691:GH9C-1007-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content."
    Maruyama F., Kobata M., Kurokawa K., Nishida K., Sakurai A., Nakano K., Nomura R., Kawabata S., Ooshima T., Nakai K., Hattori M., Hamada S., Nakagawa I.
    BMC Genomics 10:358-358(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NN2025Imported.

Entry informationi

Entry nameiC6SQI4_STRMN
AccessioniPrimary (citable) accession number: C6SQI4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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