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C6SQI4

- C6SQI4_STRMN

UniProt

C6SQI4 - C6SQI4_STRMN

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Protein

Thymidine kinase

Gene

kitH

Organism
Streptococcus mutans serotype c (strain NN2025)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei101 – 1011Proton acceptorUniRule annotation
Metal bindingi158 – 1581ZincUniRule annotation
Metal bindingi161 – 1611ZincUniRule annotation
Metal bindingi195 – 1951ZincUniRule annotation
Metal bindingi198 – 1981ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318ATPUniRule annotation
Nucleotide bindingi100 – 1034ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSMUT511691:GH9C-1007-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:kitHImported
Synonyms:tdkUniRule annotationImported
Ordered Locus Names:SmuNN2025_0950Imported
OrganismiStreptococcus mutans serotype c (strain NN2025)Imported
Taxonomic identifieri511691 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000007704: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliC6SQI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiELKTVCH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6SQI4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKWIRYQFE MGMTVLAQLY YKYGTMNSGK TIEILKVAHN YEERGKPVVI
60 70 80 90 100
MTSSLDTRDG FGVVASRIGM RREAVTITDD MDIFAYIENM FKKPYCILID
110 120 130 140 150
ESQFLSQKNV YDLARIVDEL DVPVMAFGLK NDFQNHLFEG SRELLLLADK
160 170 180 190 200
IEEIKTICQF CSKKATMVLR TENGRPVYKG NQIQIGGNET YIPVCRRHYF

HPPIKA
Length:206
Mass (Da):23,829
Last modified:September 22, 2009 - v1
Checksum:iFB925BF36118A5B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP010655 Genomic DNA. Translation: BAH87976.1.
RefSeqiYP_003484868.1. NC_013928.1.

Genome annotation databases

EnsemblBacteriaiBAH87976; BAH87976; SmuNN2025_0950.
GeneIDi8834796.
KEGGismc:SmuNN2025_0950.
PATRICi35313778. VBIStrMut11111_0941.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP010655 Genomic DNA. Translation: BAH87976.1 .
RefSeqi YP_003484868.1. NC_013928.1.

3D structure databases

ProteinModelPortali C6SQI4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH87976 ; BAH87976 ; SmuNN2025_0950 .
GeneIDi 8834796.
KEGGi smc:SmuNN2025_0950.
PATRICi 35313778. VBIStrMut11111_0941.

Phylogenomic databases

HOGENOMi HOG000076391.
KOi K00857.
OMAi ELKTVCH.

Enzyme and pathway databases

BioCyci SMUT511691:GH9C-1007-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content."
    Maruyama F., Kobata M., Kurokawa K., Nishida K., Sakurai A., Nakano K., Nomura R., Kawabata S., Ooshima T., Nakai K., Hattori M., Hamada S., Nakagawa I.
    BMC Genomics 10:358-358(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NN2025Imported.

Entry informationi

Entry nameiC6SQI4_STRMN
AccessioniPrimary (citable) accession number: C6SQI4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3