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C6SQI4

- C6SQI4_STRMN

UniProt

C6SQI4 - C6SQI4_STRMN

Protein

Thymidine kinase

Gene

kitH

Organism
Streptococcus mutans serotype c (strain NN2025)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei101 – 1011Proton acceptorUniRule annotation
    Metal bindingi158 – 1581ZincUniRule annotation
    Metal bindingi161 – 1611ZincUniRule annotation
    Metal bindingi195 – 1951ZincUniRule annotation
    Metal bindingi198 – 1981ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi24 – 318ATPUniRule annotation
    Nucleotide bindingi100 – 1034ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSMUT511691:GH9C-1007-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:kitHImported
    Synonyms:tdkUniRule annotationImported
    Ordered Locus Names:SmuNN2025_0950Imported
    OrganismiStreptococcus mutans serotype c (strain NN2025)Imported
    Taxonomic identifieri511691 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000007704: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliC6SQI4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000076391.
    KOiK00857.
    OMAiELKTVCH.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C6SQI4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKWIRYQFE MGMTVLAQLY YKYGTMNSGK TIEILKVAHN YEERGKPVVI    50
    MTSSLDTRDG FGVVASRIGM RREAVTITDD MDIFAYIENM FKKPYCILID 100
    ESQFLSQKNV YDLARIVDEL DVPVMAFGLK NDFQNHLFEG SRELLLLADK 150
    IEEIKTICQF CSKKATMVLR TENGRPVYKG NQIQIGGNET YIPVCRRHYF 200
    HPPIKA 206
    Length:206
    Mass (Da):23,829
    Last modified:September 22, 2009 - v1
    Checksum:iFB925BF36118A5B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP010655 Genomic DNA. Translation: BAH87976.1.
    RefSeqiYP_003484868.1. NC_013928.1.

    Genome annotation databases

    EnsemblBacteriaiBAH87976; BAH87976; SmuNN2025_0950.
    GeneIDi8834796.
    KEGGismc:SmuNN2025_0950.
    PATRICi35313778. VBIStrMut11111_0941.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP010655 Genomic DNA. Translation: BAH87976.1 .
    RefSeqi YP_003484868.1. NC_013928.1.

    3D structure databases

    ProteinModelPortali C6SQI4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH87976 ; BAH87976 ; SmuNN2025_0950 .
    GeneIDi 8834796.
    KEGGi smc:SmuNN2025_0950.
    PATRICi 35313778. VBIStrMut11111_0941.

    Phylogenomic databases

    HOGENOMi HOG000076391.
    KOi K00857.
    OMAi ELKTVCH.

    Enzyme and pathway databases

    BioCyci SMUT511691:GH9C-1007-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content."
      Maruyama F., Kobata M., Kurokawa K., Nishida K., Sakurai A., Nakano K., Nomura R., Kawabata S., Ooshima T., Nakai K., Hattori M., Hamada S., Nakagawa I.
      BMC Genomics 10:358-358(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NN2025Imported.

    Entry informationi

    Entry nameiC6SQI4_STRMN
    AccessioniPrimary (citable) accession number: C6SQI4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 22, 2009
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3