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Protein

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Gene

fabZ

Organism
Neisseria meningitidis (strain alpha14)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.UniRule annotationSAAS annotation

Catalytic activityi

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei53UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processLipid A biosynthesisUniRule annotationSAAS annotation, Lipid biosynthesis, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZUniRule annotation (EC:4.2.1.59UniRule annotation)
Alternative name(s):
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydrataseUniRule annotation
Short name:
(3R)-hydroxymyristoyl-ACP dehydraseUniRule annotation
Beta-hydroxyacyl-ACP dehydrataseUniRule annotation
Gene namesi
Name:fabZUniRule annotationImported
Ordered Locus Names:NMO_1859Imported
OrganismiNeisseria meningitidis (strain alpha14)Imported
Taxonomic identifieri662598 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000002054 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliC6S9B9.
SMRiC6S9B9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 140FabAInterPro annotationAdd BLAST125

Sequence similaritiesi

Belongs to the thioester dehydratase family. FabZ subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000277829.
KOiK02372.
OMAiFPGRPLM.

Family and domain databases

HAMAPiMF_00406. FabZ. 1 hit.
InterProiView protein in InterPro
IPR013114. FabA_FabZ.
IPR010084. FabZ.
IPR029069. HotDog_dom_sf.
PfamiView protein in Pfam
PF07977. FabA. 1 hit.
SUPFAMiSSF54637. SSF54637. 1 hit.
TIGRFAMsiTIGR01750. fabZ. 1 hit.

Sequencei

Sequence statusi: Complete.

C6S9B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVQLPIEAK DIQKLIPHRY PFLQLDRITA FEPMKTLTAI KNVSINEPQF
60 70 80 90 100
QGHFPDLPVM PGVLIIEAMA QACGTLAILS EGGRKENEFF FFAGIDEARF
110 120 130 140
KRQVIPGDQL VFEVELLTSR RGIGKFNAVA KVDGQVAVEA IIMCAKRVV
Length:149
Mass (Da):16,613
Last modified:September 22, 2009 - v1
Checksum:iDE6BCB39FB8DACBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM889136 Genomic DNA. Translation: CBA08338.1.
RefSeqiWP_002216259.1. NC_013016.1.

Genome annotation databases

EnsemblBacteriaiCBA08338; CBA08338; NMO_1859.
KEGGinmi:NMO_1859.

Similar proteinsi

Entry informationi

Entry nameiC6S9B9_NEIML
AccessioniPrimary (citable) accession number: C6S9B9
Entry historyiIntegrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: November 22, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported