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Protein

Bifunctional protein PutA

Gene

putA

Organism
Neisseria meningitidis (strain alpha14)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Oxidizes proline to glutamate for use as a carbon and nitrogen source.UniRule annotation

Catalytic activityi

L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH.UniRule annotation
L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: L-proline degradation into L-glutamate

This protein is involved in step 1 and 2 of the subpathway that synthesizes L-glutamate from L-proline.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Bifunctional protein PutA (putA)
  2. Bifunctional protein PutA (putA)
This subpathway is part of the pathway L-proline degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from L-proline, the pathway L-proline degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei782UniRule annotation1
Active sitei816UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, OxidoreductaseUniRule annotationImported, RepressorUniRule annotation
Biological processProline metabolismUniRule annotation, Transcription, Transcription regulationUniRule annotation
LigandFADUniRule annotation, Flavoprotein, NADUniRule annotation

Enzyme and pathway databases

BioCyciNMEN662598:G1GK2-2040-MONOMER
UniPathwayiUPA00261; UER00373
UPA00261; UER00374

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PutAUniRule annotation
Including the following 2 domains:
Proline dehydrogenaseUniRule annotation (EC:1.5.5.2UniRule annotation)
Alternative name(s):
Proline oxidaseUniRule annotation
Delta-1-pyrroline-5-carboxylate dehydrogenaseUniRule annotation (EC:1.2.1.88UniRule annotation)
Short name:
P5C dehydrogenaseUniRule annotation
Alternative name(s):
L-glutamate gamma-semialdehyde dehydrogenaseUniRule annotation
Gene namesi
Name:putAImported
Ordered Locus Names:NMO_1638Imported
OrganismiNeisseria meningitidis (strain alpha14)Imported
Taxonomic identifieri662598 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000002054 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliC6S8Q8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 176Pro_dh-DNA_bdgInterPro annotationAdd BLAST111
Domaini187 – 479Pro_dhInterPro annotationAdd BLAST293
Domaini566 – 1007AldedhInterPro annotationAdd BLAST442

Sequence similaritiesi

In the C-terminal section; belongs to the aldehyde dehydrogenase family.UniRule annotation
In the N-terminal section; belongs to the proline dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000253911
KOiK13821
OMAiVRIYAPV

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR025703 Bifunct_PutA
IPR005933 Delta1-pyrroline-5-COlate_DH-3
IPR029041 FAD-linked_oxidoreductase-like
IPR024089 PRODH_PutA_dom_I/II
IPR024082 PRODH_PutA_dom_II
IPR002872 Proline_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PF01619 Pro_dh, 1 hit
PF14850 Pro_dh-DNA_bdg, 1 hit
PIRSFiPIRSF000197 Bifunct_PutA, 1 hit
SUPFAMiSSF51730 SSF51730, 1 hit
SSF53720 SSF53720, 1 hit
SSF81935 SSF81935, 1 hit
TIGRFAMsiTIGR01238 D1pyr5carbox3, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit

Sequencei

Sequence statusi: Complete.

C6S8Q8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHFAFPAQT ALRQAITDAY RRNEIEAVQD MLQRAQMSDE ERNAASELAR
60 70 80 90 100
RLVTQVRAGR TKAGGVDALM HEFSLSSEEG IALMCLAEAL LRIPDNATRD
110 120 130 140 150
RLIADKISDG NWKSHLNNSP SLFVNAAAWG LLITGKLTAT NDKQMSSALS
160 170 180 190 200
RLISKGGAPL IRQGVNYAMR LLGKQFVTGQ TIEEALQNGK EREKMGYRFS
210 220 230 240 250
FDMLGEAAYT QADADRYYRD YVEAIHAIGK DAAGQGVYEG NGISVKLSAI
260 270 280 290 300
HPRYSRAQHG RVMGELLPRL KELFLLGKKY DIGINIDAEE ANRLELSLDL
310 320 330 340 350
MEALVSDPDL AGYKGIGFVV QAYQKRCPFV IDYLIDLARR NNQKLMIRLV
360 370 380 390 400
KGAYWDSEIK WAQVDGLNGY PTYTRKVHTD ISYLACARKL LSAQDAVFPQ
410 420 430 440 450
FATHNAYTLG AIYQMGKGKD FEHQCLHGMG ETLYDQVVGP QNLGRRVRVY
460 470 480 490 500
APVGTHETLL AYLVRRLLEN GANSSFVNQI VDENISIDTL IRSPFDTIAE
510 520 530 540 550
QGIHLHNALP LPRDLYGKCR LNSQGVDLSN ENVLQQLQEQ MNKAAAQDFH
560 570 580 590 600
AASIVNGKAR DVGEAQPIKN PADHDDIVGT VSFADAALAQ EAVGAAVAAF
610 620 630 640 650
PEWSATPAAE RAACLRRFAD LLEQHTPALM MLAVREAGKT LNNAIAEVRE
660 670 680 690 700
AVDFCRYYAN EAEHTLPQDA KAVGAIVAIS PWNFPLAIFT GEVVSALAAG
710 720 730 740 750
NTVIAKPAEQ TSLIAGYAVS LMHEAGIPTS ALQLVLGAGD VGAALTNDAR
760 770 780 790 800
IGGVIFTGST EVARLINKAL AKRGDNPVLI AETGGQNAMI VDSTALAEQV
810 820 830 840 850
CADVLNSAFD SAGQRCSALR ILCVQEDVAD RMLDMIKGAM DELVVGKPIQ
860 870 880 890 900
LTTDVGPVID AEAQQNLLNH INKMKGVAKS YHEVKTAADV DSKKSTFVRP
910 920 930 940 950
ILFELNNLNE LQREVFGPVL HVVRYRADEL DNVIDQINSK GYALTHGVHS
960 970 980 990 1000
RIEGTVRHIR SRIEAGNVYV NRNIVGAVVG VQPFGGHGLS GTGPKAGGSF
1010 1020 1030 1040 1050
YLQKLTRAGE WVAPTLSQIG QADEAALKRL EALVHKLPFN AEEKKAAAAA
1060 1070 1080 1090 1100
LGHARIRTLR RAETVLTGPT GERNSISWHA PKRVWIHGGS TVQAFAALTE
1110 1120 1130 1140 1150
LAASGVQAVV EPDSPLASYT ADLEGLLLVN DKPETAGISH VAALSPLDSA
1160 1170 1180 1190 1200
RKQELAAHDG ALIRILPSEN GLDILQVFEE ISCSVNTTAA GGNASLMAVA

D
Length:1,201
Mass (Da):129,965
Last modified:September 22, 2009 - v1
Checksum:i515B5E2A67717EBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM889136 Genomic DNA Translation: CBA07701.1
RefSeqiWP_015815858.1, NC_013016.1

Genome annotation databases

EnsemblBacteriaiCBA07701; CBA07701; NMO_1638
KEGGinmi:NMO_1638

Similar proteinsi

Entry informationi

Entry nameiC6S8Q8_NEIML
AccessioniPrimary (citable) accession number: C6S8Q8
Entry historyiIntegrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: March 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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