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C6S8Q8

- C6S8Q8_NEIML

UniProt

C6S8Q8 - C6S8Q8_NEIML

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Protein
Submitted name:

1-pyrroline-5-carboxylate dehydrogenase / proline dehydrogenase

Gene
putA, NMO_1638
Organism
Neisseria meningitidis (strain alpha14)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei782 – 7821 By similarityUniRule annotation
Active sitei816 – 8161 By similarityUniRule annotation

GO - Molecular functioni

  1. 1-pyrroline-5-carboxylate dehydrogenase activity Source: UniProtKB-EC
  2. oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Source: InterPro
  3. proline dehydrogenase activity Source: InterPro
  4. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. glutamate biosynthetic process Source: InterPro
  2. proline biosynthetic process Source: InterPro
  3. proline catabolic process to glutamate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Enzyme and pathway databases

BioCyciNMEN662598:GJMX-1636-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
1-pyrroline-5-carboxylate dehydrogenase / proline dehydrogenaseImported (EC:1.5.1.12Imported)
Gene namesi
Name:putAImported
Ordered Locus Names:NMO_1638Imported
OrganismiNeisseria meningitidis (strain alpha14)Imported
Taxonomic identifieri662598 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000002054: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi662598.NMO_1638.

Structurei

3D structure databases

ProteinModelPortaliC6S8Q8.

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0506.
HOGENOMiHOG000253911.
KOiK13821.
OMAiAGIEKHI.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di1.10.2060.10. 1 hit.
1.20.5.550. 1 hit.
3.20.20.220. 1 hit.
3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR025703. Bifunct_PutA.
IPR005933. Delta1-pyrroline-5-COlate_DH-3.
IPR029041. FAD-linked_oxidoreductase-like.
IPR024090. PRODH_PutA_dom_I.
IPR024089. PRODH_PutA_dom_I/II.
IPR024082. PRODH_PutA_dom_II.
IPR002872. Proline_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
PF01619. Pro_dh. 1 hit.
PF14850. Pro_dh-DNA_bdg. 1 hit.
[Graphical view]
PIRSFiPIRSF000197. Bifunct_PutA. 1 hit.
SUPFAMiSSF51730. SSF51730. 1 hit.
SSF53720. SSF53720. 1 hit.
SSF81935. SSF81935. 1 hit.
TIGRFAMsiTIGR01238. D1pyr5carbox3. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6S8Q8-1 [UniParc]FASTAAdd to Basket

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MFHFAFPAQT ALRQAITDAY RRNEIEAVQD MLQRAQMSDE ERNAASELAR     50
RLVTQVRAGR TKAGGVDALM HEFSLSSEEG IALMCLAEAL LRIPDNATRD 100
RLIADKISDG NWKSHLNNSP SLFVNAAAWG LLITGKLTAT NDKQMSSALS 150
RLISKGGAPL IRQGVNYAMR LLGKQFVTGQ TIEEALQNGK EREKMGYRFS 200
FDMLGEAAYT QADADRYYRD YVEAIHAIGK DAAGQGVYEG NGISVKLSAI 250
HPRYSRAQHG RVMGELLPRL KELFLLGKKY DIGINIDAEE ANRLELSLDL 300
MEALVSDPDL AGYKGIGFVV QAYQKRCPFV IDYLIDLARR NNQKLMIRLV 350
KGAYWDSEIK WAQVDGLNGY PTYTRKVHTD ISYLACARKL LSAQDAVFPQ 400
FATHNAYTLG AIYQMGKGKD FEHQCLHGMG ETLYDQVVGP QNLGRRVRVY 450
APVGTHETLL AYLVRRLLEN GANSSFVNQI VDENISIDTL IRSPFDTIAE 500
QGIHLHNALP LPRDLYGKCR LNSQGVDLSN ENVLQQLQEQ MNKAAAQDFH 550
AASIVNGKAR DVGEAQPIKN PADHDDIVGT VSFADAALAQ EAVGAAVAAF 600
PEWSATPAAE RAACLRRFAD LLEQHTPALM MLAVREAGKT LNNAIAEVRE 650
AVDFCRYYAN EAEHTLPQDA KAVGAIVAIS PWNFPLAIFT GEVVSALAAG 700
NTVIAKPAEQ TSLIAGYAVS LMHEAGIPTS ALQLVLGAGD VGAALTNDAR 750
IGGVIFTGST EVARLINKAL AKRGDNPVLI AETGGQNAMI VDSTALAEQV 800
CADVLNSAFD SAGQRCSALR ILCVQEDVAD RMLDMIKGAM DELVVGKPIQ 850
LTTDVGPVID AEAQQNLLNH INKMKGVAKS YHEVKTAADV DSKKSTFVRP 900
ILFELNNLNE LQREVFGPVL HVVRYRADEL DNVIDQINSK GYALTHGVHS 950
RIEGTVRHIR SRIEAGNVYV NRNIVGAVVG VQPFGGHGLS GTGPKAGGSF 1000
YLQKLTRAGE WVAPTLSQIG QADEAALKRL EALVHKLPFN AEEKKAAAAA 1050
LGHARIRTLR RAETVLTGPT GERNSISWHA PKRVWIHGGS TVQAFAALTE 1100
LAASGVQAVV EPDSPLASYT ADLEGLLLVN DKPETAGISH VAALSPLDSA 1150
RKQELAAHDG ALIRILPSEN GLDILQVFEE ISCSVNTTAA GGNASLMAVA 1200
D 1201
Length:1,201
Mass (Da):129,965
Last modified:September 22, 2009 - v1
Checksum:i515B5E2A67717EBD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM889136 Genomic DNA. Translation: CBA07701.1.
RefSeqiWP_015815858.1. NC_013016.1.
YP_003083787.1. NC_013016.1.

Genome annotation databases

EnsemblBacteriaiCBA07701; CBA07701; NMO_1638.
GeneIDi8222788.
KEGGinmi:NMO_1638.
PATRICi20370386. VBINeiMen141067_2141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM889136 Genomic DNA. Translation: CBA07701.1 .
RefSeqi WP_015815858.1. NC_013016.1.
YP_003083787.1. NC_013016.1.

3D structure databases

ProteinModelPortali C6S8Q8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 662598.NMO_1638.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBA07701 ; CBA07701 ; NMO_1638 .
GeneIDi 8222788.
KEGGi nmi:NMO_1638.
PATRICi 20370386. VBINeiMen141067_2141.

Phylogenomic databases

eggNOGi COG0506.
HOGENOMi HOG000253911.
KOi K13821.
OMAi AGIEKHI.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

BioCyci NMEN662598:GJMX-1636-MONOMER.

Family and domain databases

Gene3Di 1.10.2060.10. 1 hit.
1.20.5.550. 1 hit.
3.20.20.220. 1 hit.
3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR025703. Bifunct_PutA.
IPR005933. Delta1-pyrroline-5-COlate_DH-3.
IPR029041. FAD-linked_oxidoreductase-like.
IPR024090. PRODH_PutA_dom_I.
IPR024089. PRODH_PutA_dom_I/II.
IPR024082. PRODH_PutA_dom_II.
IPR002872. Proline_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
PF01619. Pro_dh. 1 hit.
PF14850. Pro_dh-DNA_bdg. 1 hit.
[Graphical view ]
PIRSFi PIRSF000197. Bifunct_PutA. 1 hit.
SUPFAMi SSF51730. SSF51730. 1 hit.
SSF53720. SSF53720. 1 hit.
SSF81935. SSF81935. 1 hit.
TIGRFAMsi TIGR01238. D1pyr5carbox3. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis."
    Schoen C., Blom J., Claus H., Schramm-Glueck A., Brandt P., Mueller T., Goesmann A., Joseph B., Konietzny S., Kurzai O., Schmitt C., Friedrich T., Linke B., Vogel U., Frosch M.
    Proc. Natl. Acad. Sci. U.S.A. 105:3473-3478(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: alpha14.

Entry informationi

Entry nameiC6S8Q8_NEIML
AccessioniPrimary (citable) accession number: C6S8Q8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: September 3, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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