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Protein
Submitted name:

1-pyrroline-5-carboxylate dehydrogenase / proline dehydrogenase

Gene

putA

Organism
Neisseria meningitidis (strain alpha14)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei782 – 7821UniRule annotation
Active sitei816 – 8161UniRule annotation

GO - Molecular functioni

  1. 1-pyrroline-5-carboxylate dehydrogenase activity Source: UniProtKB-EC
  2. oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Source: InterPro
  3. proline dehydrogenase activity Source: InterPro
  4. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. proline biosynthetic process Source: InterPro
  2. proline catabolic process to glutamate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Enzyme and pathway databases

BioCyciNMEN662598:GJMX-1636-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
1-pyrroline-5-carboxylate dehydrogenase / proline dehydrogenaseImported (EC:1.5.1.12Imported)
Gene namesi
Name:putAImported
Ordered Locus Names:NMO_1638Imported
OrganismiNeisseria meningitidis (strain alpha14)Imported
Taxonomic identifieri662598 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000002054: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi662598.NMO_1638.

Structurei

3D structure databases

ProteinModelPortaliC6S8Q8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0506.
HOGENOMiHOG000253911.
KOiK13821.
OMAiPILHVVR.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di1.10.2060.10. 1 hit.
1.20.5.550. 1 hit.
3.20.20.220. 1 hit.
3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR025703. Bifunct_PutA.
IPR005933. Delta1-pyrroline-5-COlate_DH-3.
IPR029041. FAD-linked_oxidoreductase-like.
IPR024090. PRODH_PutA_dom_I.
IPR024089. PRODH_PutA_dom_I/II.
IPR024082. PRODH_PutA_dom_II.
IPR002872. Proline_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
PF01619. Pro_dh. 1 hit.
PF14850. Pro_dh-DNA_bdg. 1 hit.
[Graphical view]
PIRSFiPIRSF000197. Bifunct_PutA. 1 hit.
SUPFAMiSSF51730. SSF51730. 1 hit.
SSF53720. SSF53720. 1 hit.
SSF81935. SSF81935. 1 hit.
TIGRFAMsiTIGR01238. D1pyr5carbox3. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6S8Q8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFHFAFPAQT ALRQAITDAY RRNEIEAVQD MLQRAQMSDE ERNAASELAR
60 70 80 90 100
RLVTQVRAGR TKAGGVDALM HEFSLSSEEG IALMCLAEAL LRIPDNATRD
110 120 130 140 150
RLIADKISDG NWKSHLNNSP SLFVNAAAWG LLITGKLTAT NDKQMSSALS
160 170 180 190 200
RLISKGGAPL IRQGVNYAMR LLGKQFVTGQ TIEEALQNGK EREKMGYRFS
210 220 230 240 250
FDMLGEAAYT QADADRYYRD YVEAIHAIGK DAAGQGVYEG NGISVKLSAI
260 270 280 290 300
HPRYSRAQHG RVMGELLPRL KELFLLGKKY DIGINIDAEE ANRLELSLDL
310 320 330 340 350
MEALVSDPDL AGYKGIGFVV QAYQKRCPFV IDYLIDLARR NNQKLMIRLV
360 370 380 390 400
KGAYWDSEIK WAQVDGLNGY PTYTRKVHTD ISYLACARKL LSAQDAVFPQ
410 420 430 440 450
FATHNAYTLG AIYQMGKGKD FEHQCLHGMG ETLYDQVVGP QNLGRRVRVY
460 470 480 490 500
APVGTHETLL AYLVRRLLEN GANSSFVNQI VDENISIDTL IRSPFDTIAE
510 520 530 540 550
QGIHLHNALP LPRDLYGKCR LNSQGVDLSN ENVLQQLQEQ MNKAAAQDFH
560 570 580 590 600
AASIVNGKAR DVGEAQPIKN PADHDDIVGT VSFADAALAQ EAVGAAVAAF
610 620 630 640 650
PEWSATPAAE RAACLRRFAD LLEQHTPALM MLAVREAGKT LNNAIAEVRE
660 670 680 690 700
AVDFCRYYAN EAEHTLPQDA KAVGAIVAIS PWNFPLAIFT GEVVSALAAG
710 720 730 740 750
NTVIAKPAEQ TSLIAGYAVS LMHEAGIPTS ALQLVLGAGD VGAALTNDAR
760 770 780 790 800
IGGVIFTGST EVARLINKAL AKRGDNPVLI AETGGQNAMI VDSTALAEQV
810 820 830 840 850
CADVLNSAFD SAGQRCSALR ILCVQEDVAD RMLDMIKGAM DELVVGKPIQ
860 870 880 890 900
LTTDVGPVID AEAQQNLLNH INKMKGVAKS YHEVKTAADV DSKKSTFVRP
910 920 930 940 950
ILFELNNLNE LQREVFGPVL HVVRYRADEL DNVIDQINSK GYALTHGVHS
960 970 980 990 1000
RIEGTVRHIR SRIEAGNVYV NRNIVGAVVG VQPFGGHGLS GTGPKAGGSF
1010 1020 1030 1040 1050
YLQKLTRAGE WVAPTLSQIG QADEAALKRL EALVHKLPFN AEEKKAAAAA
1060 1070 1080 1090 1100
LGHARIRTLR RAETVLTGPT GERNSISWHA PKRVWIHGGS TVQAFAALTE
1110 1120 1130 1140 1150
LAASGVQAVV EPDSPLASYT ADLEGLLLVN DKPETAGISH VAALSPLDSA
1160 1170 1180 1190 1200
RKQELAAHDG ALIRILPSEN GLDILQVFEE ISCSVNTTAA GGNASLMAVA

D
Length:1,201
Mass (Da):129,965
Last modified:September 22, 2009 - v1
Checksum:i515B5E2A67717EBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM889136 Genomic DNA. Translation: CBA07701.1.
RefSeqiYP_003083787.1. NC_013016.1.

Genome annotation databases

EnsemblBacteriaiCBA07701; CBA07701; NMO_1638.
GeneIDi8222788.
KEGGinmi:NMO_1638.
PATRICi20370386. VBINeiMen141067_2141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM889136 Genomic DNA. Translation: CBA07701.1.
RefSeqiYP_003083787.1. NC_013016.1.

3D structure databases

ProteinModelPortaliC6S8Q8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi662598.NMO_1638.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBA07701; CBA07701; NMO_1638.
GeneIDi8222788.
KEGGinmi:NMO_1638.
PATRICi20370386. VBINeiMen141067_2141.

Phylogenomic databases

eggNOGiCOG0506.
HOGENOMiHOG000253911.
KOiK13821.
OMAiPILHVVR.
OrthoDBiEOG6BS8QW.

Enzyme and pathway databases

BioCyciNMEN662598:GJMX-1636-MONOMER.

Family and domain databases

Gene3Di1.10.2060.10. 1 hit.
1.20.5.550. 1 hit.
3.20.20.220. 1 hit.
3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR025703. Bifunct_PutA.
IPR005933. Delta1-pyrroline-5-COlate_DH-3.
IPR029041. FAD-linked_oxidoreductase-like.
IPR024090. PRODH_PutA_dom_I.
IPR024089. PRODH_PutA_dom_I/II.
IPR024082. PRODH_PutA_dom_II.
IPR002872. Proline_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
PF01619. Pro_dh. 1 hit.
PF14850. Pro_dh-DNA_bdg. 1 hit.
[Graphical view]
PIRSFiPIRSF000197. Bifunct_PutA. 1 hit.
SUPFAMiSSF51730. SSF51730. 1 hit.
SSF53720. SSF53720. 1 hit.
SSF81935. SSF81935. 1 hit.
TIGRFAMsiTIGR01238. D1pyr5carbox3. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis."
    Schoen C., Blom J., Claus H., Schramm-Glueck A., Brandt P., Mueller T., Goesmann A., Joseph B., Konietzny S., Kurzai O., Schmitt C., Friedrich T., Linke B., Vogel U., Frosch M.
    Proc. Natl. Acad. Sci. U.S.A. 105:3473-3478(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: alpha14Imported.

Entry informationi

Entry nameiC6S8Q8_NEIML
AccessioniPrimary (citable) accession number: C6S8Q8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: February 4, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.