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C6S8Q8

- C6S8Q8_NEIML

UniProt

C6S8Q8 - C6S8Q8_NEIML

Protein
Submitted name:

1-pyrroline-5-carboxylate dehydrogenase / proline dehydrogenase

Gene

putA

Organism
Neisseria meningitidis (strain alpha14)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei782 – 7821UniRule annotation
    Active sitei816 – 8161UniRule annotation

    GO - Molecular functioni

    1. 1-pyrroline-5-carboxylate dehydrogenase activity Source: UniProtKB-EC
    2. oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Source: InterPro
    3. proline dehydrogenase activity Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. glutamate biosynthetic process Source: InterPro
    2. proline biosynthetic process Source: InterPro
    3. proline catabolic process to glutamate Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Enzyme and pathway databases

    BioCyciNMEN662598:GJMX-1636-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    1-pyrroline-5-carboxylate dehydrogenase / proline dehydrogenaseImported (EC:1.5.1.12Imported)
    Gene namesi
    Name:putAImported
    Ordered Locus Names:NMO_1638Imported
    OrganismiNeisseria meningitidis (strain alpha14)Imported
    Taxonomic identifieri662598 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000002054: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi662598.NMO_1638.

    Structurei

    3D structure databases

    ProteinModelPortaliC6S8Q8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0506.
    HOGENOMiHOG000253911.
    KOiK13821.
    OMAiAGIEKHI.
    OrthoDBiEOG6BS8QW.

    Family and domain databases

    Gene3Di1.10.2060.10. 1 hit.
    1.20.5.550. 1 hit.
    3.20.20.220. 1 hit.
    3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR025703. Bifunct_PutA.
    IPR005933. Delta1-pyrroline-5-COlate_DH-3.
    IPR029041. FAD-linked_oxidoreductase-like.
    IPR024090. PRODH_PutA_dom_I.
    IPR024089. PRODH_PutA_dom_I/II.
    IPR024082. PRODH_PutA_dom_II.
    IPR002872. Proline_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    PF01619. Pro_dh. 1 hit.
    PF14850. Pro_dh-DNA_bdg. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000197. Bifunct_PutA. 1 hit.
    SUPFAMiSSF51730. SSF51730. 1 hit.
    SSF53720. SSF53720. 1 hit.
    SSF81935. SSF81935. 1 hit.
    TIGRFAMsiTIGR01238. D1pyr5carbox3. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C6S8Q8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFHFAFPAQT ALRQAITDAY RRNEIEAVQD MLQRAQMSDE ERNAASELAR     50
    RLVTQVRAGR TKAGGVDALM HEFSLSSEEG IALMCLAEAL LRIPDNATRD 100
    RLIADKISDG NWKSHLNNSP SLFVNAAAWG LLITGKLTAT NDKQMSSALS 150
    RLISKGGAPL IRQGVNYAMR LLGKQFVTGQ TIEEALQNGK EREKMGYRFS 200
    FDMLGEAAYT QADADRYYRD YVEAIHAIGK DAAGQGVYEG NGISVKLSAI 250
    HPRYSRAQHG RVMGELLPRL KELFLLGKKY DIGINIDAEE ANRLELSLDL 300
    MEALVSDPDL AGYKGIGFVV QAYQKRCPFV IDYLIDLARR NNQKLMIRLV 350
    KGAYWDSEIK WAQVDGLNGY PTYTRKVHTD ISYLACARKL LSAQDAVFPQ 400
    FATHNAYTLG AIYQMGKGKD FEHQCLHGMG ETLYDQVVGP QNLGRRVRVY 450
    APVGTHETLL AYLVRRLLEN GANSSFVNQI VDENISIDTL IRSPFDTIAE 500
    QGIHLHNALP LPRDLYGKCR LNSQGVDLSN ENVLQQLQEQ MNKAAAQDFH 550
    AASIVNGKAR DVGEAQPIKN PADHDDIVGT VSFADAALAQ EAVGAAVAAF 600
    PEWSATPAAE RAACLRRFAD LLEQHTPALM MLAVREAGKT LNNAIAEVRE 650
    AVDFCRYYAN EAEHTLPQDA KAVGAIVAIS PWNFPLAIFT GEVVSALAAG 700
    NTVIAKPAEQ TSLIAGYAVS LMHEAGIPTS ALQLVLGAGD VGAALTNDAR 750
    IGGVIFTGST EVARLINKAL AKRGDNPVLI AETGGQNAMI VDSTALAEQV 800
    CADVLNSAFD SAGQRCSALR ILCVQEDVAD RMLDMIKGAM DELVVGKPIQ 850
    LTTDVGPVID AEAQQNLLNH INKMKGVAKS YHEVKTAADV DSKKSTFVRP 900
    ILFELNNLNE LQREVFGPVL HVVRYRADEL DNVIDQINSK GYALTHGVHS 950
    RIEGTVRHIR SRIEAGNVYV NRNIVGAVVG VQPFGGHGLS GTGPKAGGSF 1000
    YLQKLTRAGE WVAPTLSQIG QADEAALKRL EALVHKLPFN AEEKKAAAAA 1050
    LGHARIRTLR RAETVLTGPT GERNSISWHA PKRVWIHGGS TVQAFAALTE 1100
    LAASGVQAVV EPDSPLASYT ADLEGLLLVN DKPETAGISH VAALSPLDSA 1150
    RKQELAAHDG ALIRILPSEN GLDILQVFEE ISCSVNTTAA GGNASLMAVA 1200
    D 1201
    Length:1,201
    Mass (Da):129,965
    Last modified:September 22, 2009 - v1
    Checksum:i515B5E2A67717EBD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM889136 Genomic DNA. Translation: CBA07701.1.
    RefSeqiWP_015815858.1. NC_013016.1.
    YP_003083787.1. NC_013016.1.

    Genome annotation databases

    EnsemblBacteriaiCBA07701; CBA07701; NMO_1638.
    GeneIDi8222788.
    KEGGinmi:NMO_1638.
    PATRICi20370386. VBINeiMen141067_2141.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM889136 Genomic DNA. Translation: CBA07701.1 .
    RefSeqi WP_015815858.1. NC_013016.1.
    YP_003083787.1. NC_013016.1.

    3D structure databases

    ProteinModelPortali C6S8Q8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 662598.NMO_1638.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBA07701 ; CBA07701 ; NMO_1638 .
    GeneIDi 8222788.
    KEGGi nmi:NMO_1638.
    PATRICi 20370386. VBINeiMen141067_2141.

    Phylogenomic databases

    eggNOGi COG0506.
    HOGENOMi HOG000253911.
    KOi K13821.
    OMAi AGIEKHI.
    OrthoDBi EOG6BS8QW.

    Enzyme and pathway databases

    BioCyci NMEN662598:GJMX-1636-MONOMER.

    Family and domain databases

    Gene3Di 1.10.2060.10. 1 hit.
    1.20.5.550. 1 hit.
    3.20.20.220. 1 hit.
    3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR025703. Bifunct_PutA.
    IPR005933. Delta1-pyrroline-5-COlate_DH-3.
    IPR029041. FAD-linked_oxidoreductase-like.
    IPR024090. PRODH_PutA_dom_I.
    IPR024089. PRODH_PutA_dom_I/II.
    IPR024082. PRODH_PutA_dom_II.
    IPR002872. Proline_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    PF01619. Pro_dh. 1 hit.
    PF14850. Pro_dh-DNA_bdg. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000197. Bifunct_PutA. 1 hit.
    SUPFAMi SSF51730. SSF51730. 1 hit.
    SSF53720. SSF53720. 1 hit.
    SSF81935. SSF81935. 1 hit.
    TIGRFAMsi TIGR01238. D1pyr5carbox3. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis."
      Schoen C., Blom J., Claus H., Schramm-Glueck A., Brandt P., Mueller T., Goesmann A., Joseph B., Konietzny S., Kurzai O., Schmitt C., Friedrich T., Linke B., Vogel U., Frosch M.
      Proc. Natl. Acad. Sci. U.S.A. 105:3473-3478(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: alpha14Imported.

    Entry informationi

    Entry nameiC6S8Q8_NEIML
    AccessioniPrimary (citable) accession number: C6S8Q8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 22, 2009
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3