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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

aceF

Organism
Neisseria meningitidis (strain alpha14)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 2 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, Transferase
Biological processGlycolysisUniRule annotation

Enzyme and pathway databases

BioCyciNMEN662598:G1GK2-1450-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:aceFImported
Ordered Locus Names:NMO_1180Imported
OrganismiNeisseria meningitidis (strain alpha14)Imported
Taxonomic identifieri662598 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000002054 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC6S7H7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 77Lipoyl-bindingInterPro annotationAdd BLAST75
Domaini107 – 181Lipoyl-bindingInterPro annotationAdd BLAST75
Domaini234 – 271Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili424 – 444Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, LipoylUniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000281562
KOiK00627
OMAiTMEFESF

Family and domain databases

Gene3Di3.30.559.10, 1 hit
4.10.320.10, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR006256 AcTrfase_Pyrv_DH_cplx
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PANTHERiPTHR43178:SF2 PTHR43178:SF2, 3 hits
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 2 hits
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 2 hits
TIGRFAMsiTIGR01348 PDHac_trf_long, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 2 hits
PS00189 LIPOYL, 2 hits
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

C6S7H7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIVEIKVPD IGGHENVDII AVEVKAGDTI AVDDTLITLE TDKATMDVPA
60 70 80 90 100
DAAGVVKEVK VKVGDKISEG GVILTVETGA AAAEAASAAA EAQPAPAAAP
110 120 130 140 150
VAAGGATVQV AVPDIGGHTD VDVIAVEIKV GDTVAEDDTL ITLETDKATM
160 170 180 190 200
DVPCTAAGVV KAVFLKVGDK VSEGSAIIEV ETVGSAAAAP AQAAQAAAPA
210 220 230 240 250
AAPPPTAAAA PAAAPAPSAP AAAKIDEAAF AKAHAGPSAR KLARELGVDL
260 270 280 290 300
GQVKGTGLKG RIVGDDIKAF VKSVMQGGAA KPAAAGASLG SGLDLLPWPK
310 320 330 340 350
VDFSKFGNVE VKELSRIKKI SGQNLSRNWV VIPHVTVHEE ADMTELEEFR
360 370 380 390 400
KQLNKEWERE GVKLSPLAFI IKASVSALKA FPEFNASLDG DNLVLKNYFN
410 420 430 440 450
IGFAADTPNG LVVPVIKDVD QKGLKQISQE LTELSKKARE GKLKPQEMQG
460 470 480 490 500
ACFTISSLGG IGGTGFTPIV NAPEVAILGV CKSQIKPVWN GKEFAPRLMC
510 520 530
PLSLSFDHRV IDGAAGMRFT VFLAKLLKDF RRITL
Length:535
Mass (Da):55,209
Last modified:September 22, 2009 - v1
Checksum:iF05F7CDA19624106
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM889136 Genomic DNA Translation: CBA06394.1
RefSeqiWP_015815659.1, NC_013016.1

Genome annotation databases

EnsemblBacteriaiCBA06394; CBA06394; NMO_1180
KEGGinmi:NMO_1180

Entry informationi

Entry nameiC6S7H7_NEIML
AccessioniPrimary (citable) accession number: C6S7H7
Entry historyiIntegrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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