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C6S4L4

- C6S4L4_NEIML

UniProt

C6S4L4 - C6S4L4_NEIML

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Protein
Phosphoenolpyruvate carboxylase
Gene
ppc, NMO_0106
Organism
Neisseria meningitidis (strain alpha14)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotations

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei157 – 1571 By similarityUniRule annotation
Active sitei585 – 5851 By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotations

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, PyruvateImported

Enzyme and pathway databases

BioCyciNMEN662598:GJMX-109-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
Ordered Locus Names:NMO_0106Imported
OrganismiNeisseria meningitidis (strain alpha14)Imported
Taxonomic identifieri662598 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000002054: Chromosome

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi662598.NMO_0106.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiELSTISC.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6S4L4-1 [UniParc]FASTAAdd to Basket

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MRHLGYIYSI YGNERKIMQL HILNNPKDAA LAADAEFLKQ SLFNLLHEEA    50
SPLVVETVKL LSTSDDSAAL IEKVLPQLDE QQTHDLTLAC GLFAQILNIA 100
EDVHHERRRQ IHEEAGRGGA EGSLTETVRR LKAGKADGKS VQRQLDNTSV 150
TAVLTAHPTE VQRQTVLNFN RRIRALLPQR ERCTNADALA RLRREIDTIL 200
LGLWQTSETR RHKLSVNDEI NNGVSIFPMS FFEALPKLYR NMEHDFQMVY 250
PDVCVPNILK IGGWIGGDRD GNPFVSAETL RFAFRRHADA VFRFYRGELD 300
KLYRELPLSI RRVKVNDDVM ALAALSPDEE LARTEEPYRR AIAYIMARAM 350
GKARALGLGM GCKFGFLEPY ASAQEFLDDL KKLQRSLIDN GSRLLAEGRL 400
ADLIRSVSVF GFHMMPLDLR QHAGKHADVV AELFQHAGLE DYNSLDEEQK 450
QAALLRELGH QRPLYSPFIT YSDHTRRELA IFNEARKIKD EFGEDAVTQS 500
IISNCEQPGD LLALALLLKE SGLLAVENGK PRSRINIVPL FETIEALENA 550
CPVMETMFRL DWYDALLESR GNIQEIMLGY SDSNKDGGYV TSSWCLYQAE 600
LGLVELFKKY DVRMRLFHGR GGSVGRGGGP SYQAILAQPA GSVAGQIRIT 650
EQGEVITAKY ADPGNAQRNL ETLVAATLEA SILPDKKDPD AKLMQALSDV 700
SFKYYRELIT HPDFIDYFLQ TSPIQEIATL NLGSRPASRK TLARIQDLRA 750
IPWVFSWMQN RLMLPAWYGF GSAVETLCED KPETLAALRE HAQSNPFFQA 800
MLSNMEQVMA KTDITLAENY AGLSESPDKA KIIFGMIKEE YRRSRKALLD 850
LLQTEELLRD NRSLARSLAL RIPYLNALNG LQVAMLKRLR KEPDNPHALL 900
MVHLTINGVA QGLRNTG 917
Length:917
Mass (Da):103,289
Last modified:September 22, 2009 - v1
Checksum:i8C520AF1A14F7816
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM889136 Genomic DNA. Translation: CBA03503.1.
RefSeqiYP_003082350.1. NC_013016.1.

Genome annotation databases

EnsemblBacteriaiCBA03503; CBA03503; NMO_0106.
GeneIDi8222959.
KEGGinmi:NMO_0106.
PATRICi20366291. VBINeiMen141067_0125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM889136 Genomic DNA. Translation: CBA03503.1 .
RefSeqi YP_003082350.1. NC_013016.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 662598.NMO_0106.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBA03503 ; CBA03503 ; NMO_0106 .
GeneIDi 8222959.
KEGGi nmi:NMO_0106.
PATRICi 20366291. VBINeiMen141067_0125.

Phylogenomic databases

eggNOGi COG2352.
HOGENOMi HOG000238647.
KOi K01595.
OMAi ELSTISC.
OrthoDBi EOG6TJ7T8.

Enzyme and pathway databases

BioCyci NMEN662598:GJMX-109-MONOMER.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis."
    Schoen C., Blom J., Claus H., Schramm-Glueck A., Brandt P., Mueller T., Goesmann A., Joseph B., Konietzny S., Kurzai O., Schmitt C., Friedrich T., Linke B., Vogel U., Frosch M.
    Proc. Natl. Acad. Sci. U.S.A. 105:3473-3478(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: alpha14.

Entry informationi

Entry nameiC6S4L4_NEIML
AccessioniPrimary (citable) accession number: C6S4L4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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