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C6S4L4

- C6S4L4_NEIML

UniProt

C6S4L4 - C6S4L4_NEIML

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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Neisseria meningitidis (strain alpha14)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Magnesium.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei157 – 1571UniRule annotation
Active sitei585 – 5851UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciNMEN662598:GJMX-109-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
Ordered Locus Names:NMO_0106Imported
OrganismiNeisseria meningitidis (strain alpha14)Imported
Taxonomic identifieri662598 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000002054: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi662598.NMO_0106.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiELSTISC.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6S4L4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRHLGYIYSI YGNERKIMQL HILNNPKDAA LAADAEFLKQ SLFNLLHEEA
60 70 80 90 100
SPLVVETVKL LSTSDDSAAL IEKVLPQLDE QQTHDLTLAC GLFAQILNIA
110 120 130 140 150
EDVHHERRRQ IHEEAGRGGA EGSLTETVRR LKAGKADGKS VQRQLDNTSV
160 170 180 190 200
TAVLTAHPTE VQRQTVLNFN RRIRALLPQR ERCTNADALA RLRREIDTIL
210 220 230 240 250
LGLWQTSETR RHKLSVNDEI NNGVSIFPMS FFEALPKLYR NMEHDFQMVY
260 270 280 290 300
PDVCVPNILK IGGWIGGDRD GNPFVSAETL RFAFRRHADA VFRFYRGELD
310 320 330 340 350
KLYRELPLSI RRVKVNDDVM ALAALSPDEE LARTEEPYRR AIAYIMARAM
360 370 380 390 400
GKARALGLGM GCKFGFLEPY ASAQEFLDDL KKLQRSLIDN GSRLLAEGRL
410 420 430 440 450
ADLIRSVSVF GFHMMPLDLR QHAGKHADVV AELFQHAGLE DYNSLDEEQK
460 470 480 490 500
QAALLRELGH QRPLYSPFIT YSDHTRRELA IFNEARKIKD EFGEDAVTQS
510 520 530 540 550
IISNCEQPGD LLALALLLKE SGLLAVENGK PRSRINIVPL FETIEALENA
560 570 580 590 600
CPVMETMFRL DWYDALLESR GNIQEIMLGY SDSNKDGGYV TSSWCLYQAE
610 620 630 640 650
LGLVELFKKY DVRMRLFHGR GGSVGRGGGP SYQAILAQPA GSVAGQIRIT
660 670 680 690 700
EQGEVITAKY ADPGNAQRNL ETLVAATLEA SILPDKKDPD AKLMQALSDV
710 720 730 740 750
SFKYYRELIT HPDFIDYFLQ TSPIQEIATL NLGSRPASRK TLARIQDLRA
760 770 780 790 800
IPWVFSWMQN RLMLPAWYGF GSAVETLCED KPETLAALRE HAQSNPFFQA
810 820 830 840 850
MLSNMEQVMA KTDITLAENY AGLSESPDKA KIIFGMIKEE YRRSRKALLD
860 870 880 890 900
LLQTEELLRD NRSLARSLAL RIPYLNALNG LQVAMLKRLR KEPDNPHALL
910
MVHLTINGVA QGLRNTG
Length:917
Mass (Da):103,289
Last modified:September 22, 2009 - v1
Checksum:i8C520AF1A14F7816
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM889136 Genomic DNA. Translation: CBA03503.1.
RefSeqiWP_012779554.1. NC_013016.1.
YP_003082350.1. NC_013016.1.

Genome annotation databases

EnsemblBacteriaiCBA03503; CBA03503; NMO_0106.
GeneIDi8222959.
KEGGinmi:NMO_0106.
PATRICi20366291. VBINeiMen141067_0125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM889136 Genomic DNA. Translation: CBA03503.1 .
RefSeqi WP_012779554.1. NC_013016.1.
YP_003082350.1. NC_013016.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 662598.NMO_0106.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBA03503 ; CBA03503 ; NMO_0106 .
GeneIDi 8222959.
KEGGi nmi:NMO_0106.
PATRICi 20366291. VBINeiMen141067_0125.

Phylogenomic databases

eggNOGi COG2352.
HOGENOMi HOG000238647.
KOi K01595.
OMAi ELSTISC.
OrthoDBi EOG6TJ7T8.

Enzyme and pathway databases

BioCyci NMEN662598:GJMX-109-MONOMER.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis."
    Schoen C., Blom J., Claus H., Schramm-Glueck A., Brandt P., Mueller T., Goesmann A., Joseph B., Konietzny S., Kurzai O., Schmitt C., Friedrich T., Linke B., Vogel U., Frosch M.
    Proc. Natl. Acad. Sci. U.S.A. 105:3473-3478(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: alpha14Imported.

Entry informationi

Entry nameiC6S4L4_NEIML
AccessioniPrimary (citable) accession number: C6S4L4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3