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Protein
Submitted name:

Vascular endothelial growth factor 188

Gene

vegf

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chemoattractant activity Source: UniProtKB
  2. cytokine activity Source: UniProtKB
  3. fibronectin binding Source: UniProtKB
  4. growth factor activity Source: UniProtKB
  5. heparin binding Source: UniProtKB
  6. platelet-derived growth factor receptor binding Source: UniProtKB
  7. receptor agonist activity Source: UniProtKB
  8. vascular endothelial growth factor receptor 1 binding Source: UniProtKB
  9. vascular endothelial growth factor receptor 2 binding Source: UniProtKB
  10. vascular endothelial growth factor receptor binding Source: UniProtKB

GO - Biological processi

  1. activation of protein kinase activity Source: UniProtKB
  2. angiogenesis Source: UniProtKB
  3. cell migration involved in sprouting angiogenesis Source: UniProtKB
  4. cellular response to hypoxia Source: UniProtKB
  5. cellular response to vascular endothelial growth factor stimulus Source: UniProtKB
  6. endothelial cell chemotaxis Source: UniProtKB
  7. macrophage differentiation Source: UniProtKB
  8. monocyte differentiation Source: UniProtKB
  9. negative regulation of apoptotic process Source: UniProtKB
  10. positive chemotaxis Source: GOC
  11. positive regulation of angiogenesis Source: UniProtKB
  12. positive regulation of blood vessel endothelial cell migration Source: UniProtKB
  13. positive regulation of cell adhesion Source: UniProtKB
  14. positive regulation of cell division Source: UniProtKB-KW
  15. positive regulation of cell migration involved in sprouting angiogenesis Source: UniProtKB
  16. positive regulation of cell proliferation Source: UniProtKB
  17. positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway Source: UniProtKB
  18. positive regulation of cellular component movement Source: UniProtKB
  19. positive regulation of CREB transcription factor activity Source: UniProtKB
  20. positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
  21. positive regulation of endothelial cell migration Source: UniProtKB
  22. positive regulation of endothelial cell proliferation Source: UniProtKB
  23. positive regulation of MAP kinase activity Source: UniProtKB
  24. positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  25. positive regulation of peptidyl-tyrosine autophosphorylation Source: UniProtKB
  26. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  27. positive regulation of positive chemotaxis Source: UniProtKB
  28. positive regulation of protein autophosphorylation Source: UniProtKB
  29. positive regulation of protein kinase C signaling Source: UniProtKB
  30. positive regulation of protein kinase D signaling Source: BHF-UCL
  31. positive regulation of receptor internalization Source: UniProtKB
  32. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  33. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
  34. regulation of cell shape Source: UniProtKB
  35. response to hypoxia Source: UniProtKB
  36. vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Growth factorUniRule annotationSAAS annotation, MitogenUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Vascular endothelial growth factor 188Imported
Gene namesi
Name:vegfImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. extracellular space Source: UniProtKB
  4. membrane Source: InterPro
  5. secretory granule Source: UniProtKB
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.UniRule annotation

Family and domain databases

Gene3Di2.10.160.10. 1 hit.
2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR027928. VEGF_C.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
PF14554. VEGF_C. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
SSF57593. SSF57593. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6KYY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGQKPHEVV KFMDVYQRSF
60 70 80 90 100
CRPIETLVDI FQEYPDEIEF IFKPSCVPLM RCGGCCNDES LECVPTEEFN
110 120 130 140 150
ITMQIMRIKP HQSQHIGEMS FLQHNKCECR PKKDKARQEK KSVRGKGKGQ
160 170 180 190 200
KRKRKKSRYK SWSAPCGPCS ERRKHLFVQD PQTCKCSCKN TDSRCKARQL
210
ELNERTCRCD KPRR
Length:214
Mass (Da):25,141
Last modified:September 22, 2009 - v1
Checksum:i5C309623C47AF67B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB450824 mRNA. Translation: BAH86639.1.
UniGeneiBt.4138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB450824 mRNA. Translation: BAH86639.1.
UniGeneiBt.4138.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.10.160.10. 1 hit.
2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR027928. VEGF_C.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
PF14554. VEGF_C. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
SSF57593. SSF57593. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Gene expression of vascular endothelial growth factor in bovine mammary epithelial cells."
    Nakajima K., Nakamura M., Ishisaki A., Kozakai T.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.

Entry informationi

Entry nameiC6KYY4_BOVIN
AccessioniPrimary (citable) accession number: C6KYY4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: January 7, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.