C6KYY4 (C6KYY4_BOVIN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Vascular endothelial growth factor 188 EMBL BAH86639.1

Gene names

Name:

vegf EMBL BAH86639.1

Organism

Bos taurus (Bovine) EMBL BAH86639.1

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the PDGF/VEGF growth factor family. RuleBase RU003818

Ontologies

Keywords
Molecular function	Growth factor SAAS SAAS023581 RuleBase RU003818 Mitogen RuleBase RU003819
Gene Ontology (GO)
Biological_process	activation of protein kinase activity Inferred from sequence or structural similarity. Source: UniProtKB cell migration involved in sprouting angiogenesis Inferred from sequence or structural similarity. Source: UniProtKB cellular response to hypoxia Inferred from sequence or structural similarity. Source: UniProtKB endothelial cell chemotaxis Inferred from sequence or structural similarity. Source: UniProtKB macrophage differentiation Inferred from sequence or structural similarity. Source: UniProtKB monocyte differentiation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of CREB transcription factor activity Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of MAP kinase activity Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cell adhesion Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of cell migration involved in sprouting angiogenesis Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of endothelial cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of peptidyl-serine phosphorylation Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of peptidyl-tyrosine autophosphorylation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of positive chemotaxis Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of protein kinase C signaling cascade Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of receptor internalization Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of vascular endothelial growth factor receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB regulation of cell shape Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cell surface Inferred from sequence or structural similarity. Source: UniProtKB extracellular space Inferred from sequence or structural similarity. Source: UniProtKB membrane Inferred from electronic annotation. Source: InterPro secretory granule Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	cell surface binding Inferred from sequence or structural similarity. Source: UniProtKB chemoattractant activity Inferred from sequence or structural similarity. Source: UniProtKB cytokine activity Inferred from sequence or structural similarity. Source: UniProtKB fibronectin binding Inferred from sequence or structural similarity. Source: UniProtKB growth factor activity Inferred from sequence or structural similarity. Source: UniProtKB heparin binding Inferred from sequence or structural similarity. Source: UniProtKB platelet-derived growth factor receptor binding Inferred from sequence or structural similarity. Source: UniProtKB receptor agonist activity Inferred from sequence or structural similarity. Source: UniProtKB vascular endothelial growth factor receptor 1 binding Inferred from sequence or structural similarity. Source: UniProtKB vascular endothelial growth factor receptor 2 binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C6KYY4 [UniParc]. Last modified September 22, 2009. Version 1. Checksum: 5C309623C47AF67B	FASTA	214	25,141
	10 20 30 40 50 60 MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGQKPHEVV KFMDVYQRSF CRPIETLVDI 70 80 90 100 110 120 FQEYPDEIEF IFKPSCVPLM RCGGCCNDES LECVPTEEFN ITMQIMRIKP HQSQHIGEMS 130 140 150 160 170 180 FLQHNKCECR PKKDKARQEK KSVRGKGKGQ KRKRKKSRYK SWSAPCGPCS ERRKHLFVQD 190 200 210 PQTCKCSCKN TDSRCKARQL ELNERTCRCD KPRR

References

[1]	"Gene expression of vascular endothelial growth factor in bovine mammary epithelial cells." Nakajima K., Nakamura M., Ishisaki A., Kozakai T. Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Mammary gland EMBL BAH86639.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB450824 mRNA. Translation: BAH86639.1.
IPI	IPI00944880.
UniGene	Bt.4138.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000072. PD_growth_factor. IPR023581. PD_growth_factor_CS. [Graphical view]
Pfam	PF00341. PDGF. 1 hit. [Graphical view]
SMART	SM00141. PDGF. 1 hit. [Graphical view]
PROSITE	PS00249. PDGF_1. 1 hit. PS50278. PDGF_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C6KYY4_BOVIN

Accession

Primary (citable) accession number: C6KYY4

Entry history

Integrated into UniProtKB/TrEMBL:	September 22, 2009
Last sequence update:	September 22, 2009
Last modified:	February 6, 2013
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)