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C6KYY4

- C6KYY4_BOVIN

UniProt

C6KYY4 - C6KYY4_BOVIN

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Protein
Submitted name:

Vascular endothelial growth factor 188

Gene
vegf
Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chemoattractant activity Source: UniProtKB
  2. cytokine activity Source: UniProtKB
  3. fibronectin binding Source: UniProtKB
  4. growth factor activity Source: UniProtKB
  5. heparin binding Source: UniProtKB
  6. platelet-derived growth factor receptor binding Source: UniProtKB
  7. receptor agonist activity Source: UniProtKB
  8. vascular endothelial growth factor receptor 1 binding Source: UniProtKB
  9. vascular endothelial growth factor receptor 2 binding Source: UniProtKB
  10. vascular endothelial growth factor receptor binding Source: UniProtKB

GO - Biological processi

  1. activation of protein kinase activity Source: UniProtKB
  2. angiogenesis Source: UniProtKB
  3. cell migration involved in sprouting angiogenesis Source: UniProtKB
  4. cellular response to hypoxia Source: UniProtKB
  5. cellular response to vascular endothelial growth factor stimulus Source: UniProtKB
  6. endothelial cell chemotaxis Source: UniProtKB
  7. macrophage differentiation Source: UniProtKB
  8. monocyte differentiation Source: UniProtKB
  9. negative regulation of apoptotic process Source: UniProtKB
  10. positive chemotaxis Source: GOC
  11. positive regulation of angiogenesis Source: UniProtKB
  12. positive regulation of blood vessel endothelial cell migration Source: UniProtKB
  13. positive regulation of cell adhesion Source: UniProtKB
  14. positive regulation of cell division Source: UniProtKB-KW
  15. positive regulation of cell migration involved in sprouting angiogenesis Source: UniProtKB
  16. positive regulation of cell proliferation Source: UniProtKB
  17. positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway Source: UniProtKB
  18. positive regulation of cellular component movement Source: UniProtKB
  19. positive regulation of CREB transcription factor activity Source: UniProtKB
  20. positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
  21. positive regulation of endothelial cell migration Source: UniProtKB
  22. positive regulation of endothelial cell proliferation Source: UniProtKB
  23. positive regulation of intracellular signal transduction Source: UniProtKB
  24. positive regulation of MAP kinase activity Source: UniProtKB
  25. positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  26. positive regulation of peptidyl-tyrosine autophosphorylation Source: UniProtKB
  27. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  28. positive regulation of positive chemotaxis Source: UniProtKB
  29. positive regulation of protein autophosphorylation Source: UniProtKB
  30. positive regulation of protein kinase C signaling Source: UniProtKB
  31. positive regulation of receptor internalization Source: UniProtKB
  32. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  33. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
  34. regulation of cell shape Source: UniProtKB
  35. response to hypoxia Source: UniProtKB
  36. vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Growth factorUniRule annotationSAAS annotations, MitogenUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Vascular endothelial growth factor 188Imported
Gene namesi
Name:vegfImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. extracellular space Source: UniProtKB
  4. membrane Source: InterPro
  5. secretory granule Source: UniProtKB
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.UniRule annotation

Family and domain databases

Gene3Di2.10.160.10. 1 hit.
2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR027928. VEGF_C.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
PF14554. VEGF_C. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
SSF57593. SSF57593. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6KYY4-1 [UniParc]FASTAAdd to Basket

« Hide

MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGQKPHEVV KFMDVYQRSF    50
CRPIETLVDI FQEYPDEIEF IFKPSCVPLM RCGGCCNDES LECVPTEEFN 100
ITMQIMRIKP HQSQHIGEMS FLQHNKCECR PKKDKARQEK KSVRGKGKGQ 150
KRKRKKSRYK SWSAPCGPCS ERRKHLFVQD PQTCKCSCKN TDSRCKARQL 200
ELNERTCRCD KPRR 214
Length:214
Mass (Da):25,141
Last modified:September 22, 2009 - v1
Checksum:i5C309623C47AF67B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB450824 mRNA. Translation: BAH86639.1.
UniGeneiBt.4138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB450824 mRNA. Translation: BAH86639.1 .
UniGenei Bt.4138.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.10.160.10. 1 hit.
2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR027928. VEGF_C.
[Graphical view ]
Pfami PF00341. PDGF. 1 hit.
PF14554. VEGF_C. 1 hit.
[Graphical view ]
SMARTi SM00141. PDGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
SSF57593. SSF57593. 1 hit.
PROSITEi PS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gene expression of vascular endothelial growth factor in bovine mammary epithelial cells."
    Nakajima K., Nakamura M., Ishisaki A., Kozakai T.
    Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.

Entry informationi

Entry nameiC6KYY4_BOVIN
AccessioniPrimary (citable) accession number: C6KYY4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: June 11, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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