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C6KYY4 (C6KYY4_BOVIN) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:vegf EMBL BAH86639.1
OrganismBos taurus (Bovine) EMBL BAH86639.1
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length214 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the PDGF/VEGF growth factor family. RuleBase RU003818

Ontologies

Keywords
   Molecular functionGrowth factor SAAS SAAS000072 RuleBase RU003818
Mitogen RuleBase RU003819 SAAS SAAS029034
Gene Ontology (GO)
   Biological_processactivation of protein kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

angiogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

cell migration involved in sprouting angiogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to hypoxia

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to vascular endothelial growth factor stimulus

Inferred from sequence or structural similarity. Source: UniProtKB

endothelial cell chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

macrophage differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

monocyte differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

positive chemotaxis

Inferred from sequence or structural similarity. Source: GOC

positive regulation of CREB transcription factor activity

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of MAP kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of angiogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of blood vessel endothelial cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cell adhesion

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cell division

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of cell migration involved in sprouting angiogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cellular component movement

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of endothelial cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of endothelial cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of intracellular signal transduction

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of peptidyl-serine phosphorylation

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of peptidyl-tyrosine autophosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of positive chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of protein autophosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of protein kinase C signaling

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of receptor internalization

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of vascular endothelial growth factor receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of cell shape

Inferred from sequence or structural similarity. Source: UniProtKB

response to hypoxia

Inferred from sequence or structural similarity. Source: UniProtKB

vascular endothelial growth factor receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcell surface

Inferred from sequence or structural similarity. Source: UniProtKB

cytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

extracellular space

Inferred from sequence or structural similarity. Source: UniProtKB

membrane

Inferred from electronic annotation. Source: InterPro

secretory granule

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionchemoattractant activity

Inferred from sequence or structural similarity. Source: UniProtKB

cytokine activity

Inferred from sequence or structural similarity. Source: UniProtKB

fibronectin binding

Inferred from sequence or structural similarity. Source: UniProtKB

growth factor activity

Inferred from sequence or structural similarity. Source: UniProtKB

heparin binding

Inferred from sequence or structural similarity. Source: UniProtKB

platelet-derived growth factor receptor binding

Inferred from sequence or structural similarity. Source: UniProtKB

receptor agonist activity

Inferred from sequence or structural similarity. Source: UniProtKB

vascular endothelial growth factor receptor 1 binding

Inferred from sequence or structural similarity. Source: UniProtKB

vascular endothelial growth factor receptor 2 binding

Inferred from sequence or structural similarity. Source: UniProtKB

vascular endothelial growth factor receptor binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
C6KYY4 [UniParc].

Last modified September 22, 2009. Version 1.
Checksum: 5C309623C47AF67B

FASTA21425,141
        10         20         30         40         50         60 
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGQKPHEVV KFMDVYQRSF CRPIETLVDI 

        70         80         90        100        110        120 
FQEYPDEIEF IFKPSCVPLM RCGGCCNDES LECVPTEEFN ITMQIMRIKP HQSQHIGEMS 

       130        140        150        160        170        180 
FLQHNKCECR PKKDKARQEK KSVRGKGKGQ KRKRKKSRYK SWSAPCGPCS ERRKHLFVQD 

       190        200        210 
PQTCKCSCKN TDSRCKARQL ELNERTCRCD KPRR 

« Hide

References

[1]"Gene expression of vascular endothelial growth factor in bovine mammary epithelial cells."
Nakajima K., Nakamura M., Ishisaki A., Kozakai T.
Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Mammary gland EMBL BAH86639.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB450824 mRNA. Translation: BAH86639.1.
UniGeneBt.4138.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.10.160.10. 1 hit.
2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR027928. VEGF_C.
[Graphical view]
PfamPF00341. PDGF. 1 hit.
PF14554. VEGF_C. 1 hit.
[Graphical view]
SMARTSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
SSF57593. SSF57593. 1 hit.
PROSITEPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC6KYY4_BOVIN
AccessionPrimary (citable) accession number: C6KYY4
Entry history
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: June 11, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)