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C6KYY4

- C6KYY4_BOVIN

UniProt

C6KYY4 - C6KYY4_BOVIN

Protein
Submitted name:

Vascular endothelial growth factor 188

Gene

vegf

Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chemoattractant activity Source: UniProtKB
    2. cytokine activity Source: UniProtKB
    3. fibronectin binding Source: UniProtKB
    4. growth factor activity Source: UniProtKB
    5. heparin binding Source: UniProtKB
    6. platelet-derived growth factor receptor binding Source: UniProtKB
    7. receptor agonist activity Source: UniProtKB
    8. vascular endothelial growth factor receptor 1 binding Source: UniProtKB
    9. vascular endothelial growth factor receptor 2 binding Source: UniProtKB
    10. vascular endothelial growth factor receptor binding Source: UniProtKB

    GO - Biological processi

    1. activation of protein kinase activity Source: UniProtKB
    2. angiogenesis Source: UniProtKB
    3. cell migration involved in sprouting angiogenesis Source: UniProtKB
    4. cellular response to hypoxia Source: UniProtKB
    5. cellular response to vascular endothelial growth factor stimulus Source: UniProtKB
    6. endothelial cell chemotaxis Source: UniProtKB
    7. macrophage differentiation Source: UniProtKB
    8. monocyte differentiation Source: UniProtKB
    9. negative regulation of apoptotic process Source: UniProtKB
    10. positive chemotaxis Source: GOC
    11. positive regulation of angiogenesis Source: UniProtKB
    12. positive regulation of blood vessel endothelial cell migration Source: UniProtKB
    13. positive regulation of cell adhesion Source: UniProtKB
    14. positive regulation of cell division Source: UniProtKB-KW
    15. positive regulation of cell migration involved in sprouting angiogenesis Source: UniProtKB
    16. positive regulation of cell proliferation Source: UniProtKB
    17. positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway Source: UniProtKB
    18. positive regulation of cellular component movement Source: UniProtKB
    19. positive regulation of CREB transcription factor activity Source: UniProtKB
    20. positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
    21. positive regulation of endothelial cell migration Source: UniProtKB
    22. positive regulation of endothelial cell proliferation Source: UniProtKB
    23. positive regulation of intracellular signal transduction Source: UniProtKB
    24. positive regulation of MAP kinase activity Source: UniProtKB
    25. positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
    26. positive regulation of peptidyl-tyrosine autophosphorylation Source: UniProtKB
    27. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
    28. positive regulation of positive chemotaxis Source: UniProtKB
    29. positive regulation of protein autophosphorylation Source: UniProtKB
    30. positive regulation of protein kinase C signaling Source: UniProtKB
    31. positive regulation of receptor internalization Source: UniProtKB
    32. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    33. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
    34. regulation of cell shape Source: UniProtKB
    35. response to hypoxia Source: UniProtKB
    36. vascular endothelial growth factor receptor signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Growth factorUniRule annotationSAAS annotation, MitogenUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Vascular endothelial growth factor 188Imported
    Gene namesi
    Name:vegfImported
    OrganismiBos taurus (Bovine)Imported
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. extracellular space Source: UniProtKB
    4. membrane Source: InterPro
    5. secretory granule Source: UniProtKB

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PDGF/VEGF growth factor family.UniRule annotation

    Family and domain databases

    Gene3Di2.10.160.10. 1 hit.
    2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR023581. PD_growth_factor_CS.
    IPR000072. PDGF/VEGF_dom.
    IPR027928. VEGF_C.
    [Graphical view]
    PfamiPF00341. PDGF. 1 hit.
    PF14554. VEGF_C. 1 hit.
    [Graphical view]
    SMARTiSM00141. PDGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    SSF57593. SSF57593. 1 hit.
    PROSITEiPS00249. PDGF_1. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C6KYY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGQKPHEVV KFMDVYQRSF    50
    CRPIETLVDI FQEYPDEIEF IFKPSCVPLM RCGGCCNDES LECVPTEEFN 100
    ITMQIMRIKP HQSQHIGEMS FLQHNKCECR PKKDKARQEK KSVRGKGKGQ 150
    KRKRKKSRYK SWSAPCGPCS ERRKHLFVQD PQTCKCSCKN TDSRCKARQL 200
    ELNERTCRCD KPRR 214
    Length:214
    Mass (Da):25,141
    Last modified:September 22, 2009 - v1
    Checksum:i5C309623C47AF67B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB450824 mRNA. Translation: BAH86639.1.
    UniGeneiBt.4138.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB450824 mRNA. Translation: BAH86639.1 .
    UniGenei Bt.4138.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.10.160.10. 1 hit.
    2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR023581. PD_growth_factor_CS.
    IPR000072. PDGF/VEGF_dom.
    IPR027928. VEGF_C.
    [Graphical view ]
    Pfami PF00341. PDGF. 1 hit.
    PF14554. VEGF_C. 1 hit.
    [Graphical view ]
    SMARTi SM00141. PDGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    SSF57593. SSF57593. 1 hit.
    PROSITEi PS00249. PDGF_1. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene expression of vascular endothelial growth factor in bovine mammary epithelial cells."
      Nakajima K., Nakamura M., Ishisaki A., Kozakai T.
      Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Mammary glandImported.

    Entry informationi

    Entry nameiC6KYY4_BOVIN
    AccessioniPrimary (citable) accession number: C6KYY4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 22, 2009
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)