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C6KXN3

- C6KXN3_HUMAN

UniProt

C6KXN3 - C6KXN3_HUMAN

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Protein
Submitted name:

Lambda light chain of human immunoglobulin surface antigen-related protein

Gene

IgLC-rG

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Lambda light chain of human immunoglobulin surface antigen-related proteinImported
Gene namesi
Name:IgLC-rGImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AIXX-ray1.80A/B/C/D20-126[»]
4AJ0X-ray1.70A/B/C/D20-126[»]
4QHKX-ray3.49J/L/N/P20-232[»]
4QHLX-ray3.15B/D20-232[»]
4QHMX-ray3.23B/D/F/H20-232[»]
4QHNX-ray3.00B20-232[»]
ProteinModelPortaliC6KXN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000059537.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

C6KXN3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAWIPLFLGV LAYCTGSVAS YELTQPPLVS VSPGQTASIT CSGDKLGDNY
60 70 80 90 100
ACWYQLKPGQ SPVLVIYQDN RRPSGIPERI SGSNSGNTAT LTISGTQAMD
110 120 130 140 150
EAEYYCQAWD SSTSWVFGGG TKLTVLGQPK AAPSVTLFPP SSEELQANKA
160 170 180 190 200
TLVCLISDFY PGAVTVAWKA DSSPVKAGVE TTTPSKQSNN KYAASSYLSL
210 220 230
TPEQWKSHRS YSCQVTHEGS TVEKTVAPTE CS
Length:232
Mass (Da):24,742
Last modified:September 22, 2009 - v1
Checksum:i3DF77E9EE174E1EA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei232 – 2321Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB369252 mRNA. Translation: BAH86638.1.
UniGeneiHs.449585.
Hs.625768.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB369252 mRNA. Translation: BAH86638.1 .
UniGenei Hs.449585.
Hs.625768.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4AIX X-ray 1.80 A/B/C/D 20-126 [» ]
4AJ0 X-ray 1.70 A/B/C/D 20-126 [» ]
4QHK X-ray 3.49 J/L/N/P 20-232 [» ]
4QHL X-ray 3.15 B/D 20-232 [» ]
4QHM X-ray 3.23 B/D/F/H 20-232 [» ]
4QHN X-ray 3.00 B 20-232 [» ]
ProteinModelPortali C6KXN3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOGENOMi HOG000059537.

Miscellaneous databases

NextBioi 35483348.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Activation of cyclosporin A transport by a novel lambda light chain of human Ig surface antigen-related gene in Xenopus laevis oocytes."
    Kobayashi Y., Umemoto T., Ohbayashi M., Kohyama N., Sanada Y., Yamamoto T.
    Drug Metab. Dispos. 38:1427-1435(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Light Chain Amyloidosis Lambda 3 and Lambda 6 Two Different Stories of the Same Phenomenom."
    Villalba M.I., Luna O.D., Rudino-Pinera E., Sanchez R., Sanchez-Lopez R., Rojas-Trejo S., Olamendi-Portugal T., Fernandez-Velasco D.A., Becerril B.
    Submitted (FEB-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 20-126, ACTIVE SITE.
  3. "Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains."
    Fera D., Schmidt A.G., Haynes B.F., Gao F., Liao H.X., Kepler T.B., Harrison S.C.
    Proc. Natl. Acad. Sci. U.S.A. 111:10275-10280(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 20-232, ACTIVE SITE.

Entry informationi

Entry nameiC6KXN3_HUMAN
AccessioniPrimary (citable) accession number: C6KXN3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2009
Last sequence update: September 22, 2009
Last modified: November 26, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3