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C6KXN3

- C6KXN3_HUMAN

UniProt

C6KXN3 - C6KXN3_HUMAN

Protein
Submitted name:

Lambda light chain of human immunoglobulin surface antigen-related protein

Gene

IgLC-rG

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei67 – 671AcetateImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Lambda light chain of human immunoglobulin surface antigen-related proteinImported
    Gene namesi
    Name:IgLC-rGImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4AIXX-ray1.80A/B/C/D20-126[»]
    4AJ0X-ray1.70A/B/C/D20-126[»]
    4QHKX-ray3.49J/L/N/P20-232[»]
    4QHLX-ray3.15B/D20-232[»]
    4QHMX-ray3.23B/D/F/H20-232[»]
    4QHNX-ray3.00B20-232[»]
    ProteinModelPortaliC6KXN3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000059537.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    SM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    C6KXN3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAWIPLFLGV LAYCTGSVAS YELTQPPLVS VSPGQTASIT CSGDKLGDNY    50
    ACWYQLKPGQ SPVLVIYQDN RRPSGIPERI SGSNSGNTAT LTISGTQAMD 100
    EAEYYCQAWD SSTSWVFGGG TKLTVLGQPK AAPSVTLFPP SSEELQANKA 150
    TLVCLISDFY PGAVTVAWKA DSSPVKAGVE TTTPSKQSNN KYAASSYLSL 200
    TPEQWKSHRS YSCQVTHEGS TVEKTVAPTE CS 232
    Length:232
    Mass (Da):24,742
    Last modified:September 22, 2009 - v1
    Checksum:i3DF77E9EE174E1EA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei232 – 2321Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB369252 mRNA. Translation: BAH86638.1.
    UniGeneiHs.449585.
    Hs.625768.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB369252 mRNA. Translation: BAH86638.1 .
    UniGenei Hs.449585.
    Hs.625768.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4AIX X-ray 1.80 A/B/C/D 20-126 [» ]
    4AJ0 X-ray 1.70 A/B/C/D 20-126 [» ]
    4QHK X-ray 3.49 J/L/N/P 20-232 [» ]
    4QHL X-ray 3.15 B/D 20-232 [» ]
    4QHM X-ray 3.23 B/D/F/H 20-232 [» ]
    4QHN X-ray 3.00 B 20-232 [» ]
    ProteinModelPortali C6KXN3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOGENOMi HOG000059537.

    Miscellaneous databases

    NextBioi 35483348.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Activation of cyclosporin A transport by a novel lambda light chain of human Ig surface antigen-related gene in Xenopus laevis oocytes."
      Kobayashi Y., Umemoto T., Ohbayashi M., Kohyama N., Sanada Y., Yamamoto T.
      Drug Metab. Dispos. 38:1427-1435(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Light Chain Amyloidosis Lambda 3 and Lambda 6 Two Different Stories of the Same Phenomenom."
      Villalba M.I., Luna O.D., Rudino-Pinera E., Sanchez R., Sanchez-Lopez R., Rojas-Trejo S., Olamendi-Portugal T., Fernandez-Velasco D.A., Becerril B.
      Submitted (FEB-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 20-126.
    3. "Antibody Affinity Maturation in an HIV Broadly Neutralizing B-cell Lineage: a Shift in Relative Orientation of Light- and Heavy-Chain Variable Domains."
      Fera D., Schmidt A.G., Haynes B.F., Gao F., Liao H.X., Kepler T.B., Harrison S.C.
      Submitted (MAY-2014) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (3.15 ANGSTROMS) OF 20-232.

    Entry informationi

    Entry nameiC6KXN3_HUMAN
    AccessioniPrimary (citable) accession number: C6KXN3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 22, 2009
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3