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Protein

RNA helicase

Gene

PF3D7_0630900

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent RNA helicase activity Source: GeneDB
  • RNA binding Source: GeneDB

GO - Biological processi

  • DNA duplex unwinding Source: GeneDB
  • RNA metabolic process Source: GeneDB
  • RNA secondary structure unwinding Source: GeneDB

Keywordsi

Molecular functionHelicaseUniRule annotationSAAS annotationImported, Hydrolase, RNA-bindingSAAS annotation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA helicaseSAAS annotation (EC:3.6.4.13SAAS annotation)
Gene namesi
ORF Names:PF3D7_0630900Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0630900.

Subcellular locationi

GO - Cellular componenti

Structurei

3D structure databases

ProteinModelPortaliC6KTE4.
SMRiC6KTE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini148 – 176Q_MOTIFInterPro annotationAdd BLAST29
Domaini179 – 354Helicase ATP-bindingInterPro annotationAdd BLAST176
Domaini365 – 525Helicase C-terminalInterPro annotationAdd BLAST161

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili33 – 60Sequence analysisAdd BLAST28
Coiled coili72 – 106Sequence analysisAdd BLAST35

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi148 – 176Q motifPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the DEAD box helicase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000268799.
InParanoidiC6KTE4.
KOiK13179.
OMAiEMRQIVK.
PhylomeDBiC6KTE4.

Family and domain databases

CDDicd00079. HELICc. 1 hit.
InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR025313. DUF4217.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF13959. DUF4217. 1 hit.
PF00271. Helicase_C. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM01178. DUF4217. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiView protein in PROSITE
PS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.

Sequencei

Sequence statusi: Complete.

C6KTE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDDDNDYNT MKNSNDNNLK KTKKNSIIKK KKKKKKKEIL ENKDSNIDNL
60 70 80 90 100
KNENYRSESE AESESTNDSV SLNNIEEDNE LNENSENNEN NENDEDNKNN
110 120 130 140 150
KNNENNENTS SEEICDHDKN DKTYTDEIKS NNSDHNNNNS KEHFYSELKF
160 170 180 190 200
EELNICDALK KGLKELNFVT LTEIQAKCIP HFLSGKDILG AAKTGSGKTL
210 220 230 240 250
AFLVPSINIL YNIKFLPKNG TGVLIISPTR ELCLQIYQVC KDLCKYIPQT
260 270 280 290 300
NGIIIGGMSR NEEKKKFIHG INILIATPGR LLDHMQNTKE FIYKNLICLI
310 320 330 340 350
IDEADRLLQI GFEEEINLII KRLPKKRQTA LFSATQTTKV ESLIRLSLQK
360 370 380 390 400
PIFIEVTTKI ATVERLQQGY ALVDEDKRFL LLFTFLKKNM SKKIMVFFNN
410 420 430 440 450
CMSVQFYNDL LNYIDIPTYC IHGKKKQNKR LKSFHDFSAA KCAILLCTNV
460 470 480 490 500
AARGLDIPNV NYIIQYDPPD DSKEYIHRVG RTCRGQDSNG SAIIFLMKHE
510 520 530 540 550
LKFLNYLKFY NIPINQFAYD PNKLINIQSH IQSIVTKNFH LHKMAREAFK
560 570 580 590 600
SYLNGYITYA LKDVFDVNNL NLLLTSKNFG LEVPPKVDLN LKLNVKKKKF

K
Length:601
Mass (Da):69,359
Last modified:September 1, 2009 - v1
Checksum:iF026F5A36EDC13D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844505 Genomic DNA. Translation: CAG25121.1.
RefSeqiXP_966291.1. XM_961198.1.

Genome annotation databases

EnsemblProtistsiCAG25121; CAG25121; PF3D7_0630900.
GeneDBiPF3D7_0630900.1:pep.
GeneIDi3885813.
KEGGipfa:PFF1500c.

Similar proteinsi

Entry informationi

Entry nameiC6KTE4_PLAF7
AccessioniPrimary (citable) accession number: C6KTE4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: October 25, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported