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Protein
Submitted name:

DNA polymerase epsilon catalytic subunit A,putative

Gene

PF3D7_0630300

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseImported, Transferase

Enzyme and pathway databases

ReactomeiR-PFA-174430. Telomere C-strand synthesis initiation.
R-PFA-68952. DNA replication initiation.
R-PFA-68962. Activation of the pre-replicative complex.

Names & Taxonomyi

Protein namesi
Submitted name:
DNA polymerase epsilon catalytic subunit A,putativeImported (EC:2.7.7.7Imported)
Gene namesi
ORF Names:PF3D7_0630300Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0630300.

Subcellular locationi

GO - Cellular componenti

  • epsilon DNA polymerase complex Source: GeneDB

Interactioni

Protein-protein interaction databases

IntActiC6KTD8. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliC6KTD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1963 – 2517DUF1744InterPro annotationAdd BLAST555

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili100 – 120Sequence analysisAdd BLAST21
Coiled coili1579 – 1604Sequence analysisAdd BLAST26
Coiled coili2239 – 2259Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000281650.
InParanoidiC6KTD8.
KOiK02324.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.90.1600.10. 1 hit.
InterProiView protein in InterPro
IPR006172. DNA-dir_DNA_pol_B.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR013697. DNA_pol_e_suA_C.
IPR023211. DNA_pol_palm_dom_sf.
IPR029703. POL2.
IPR012337. RNaseH-like_sf.
IPR036397. RNaseH_sf.
PANTHERiPTHR10670. PTHR10670. 1 hit.
PfamiView protein in Pfam
PF03104. DNA_pol_B_exo1. 1 hit.
SMARTiView protein in SMART
SM01159. DUF1744. 1 hit.
SM00486. POLBc. 1 hit.
SUPFAMiSSF53098. SSF53098. 2 hits.

Sequencei

Sequence statusi: Complete.

C6KTD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTQTRTKGW EKESKINPDY EYERLLKLEN KFHIKAWINK GEKEGYLYNI
60 70 80 90 100
VPTTMNVVAK NSNKSHKKTG VHMYFVSDNN KTWRLTLFYR PYFYLKTKNI
110 120 130 140 150
HNYEQVTKFL KKELDKYNVE IDYVKKEDLS LYDHLNKKRS YLSNIFFKLS
160 170 180 190 200
YDTIENLMNA RDFLVKIIER NKKQNKNYNN SNNDKHIFNN EDLSYSQLEF
210 220 230 240 250
SYKNEYSYNK YDDQKENTQK QQFTTNITEE DDKKRILNAK SNDNNNNNNN
260 270 280 290 300
NTHNSNNNNN ILNMNDIIVT TKKQILSKEE IMNEIIEIYE YDVKYLTRIC
310 320 330 340 350
IDKNIRCGLW YKVKREEDEL YTELIQFEIL NKKVLAPLNI LAWDIECYKD
360 370 380 390 400
ELKFPDKEKD EIILISYMYN AQGYLIVNRN VMSKNIREFL YKPNEEYSGA
410 420 430 440 450
GTFKIFNEKN EYFLLKRFLE HIRLLKIHIF VTYNGDFFDI PYLYRRCEIN
460 470 480 490 500
NLSVSREIGF IMNNKQECSC NFILNIDAYK WVERDSYLPN GSRTLKSVCK
510 520 530 540 550
IKLKYNPTEV DPELMVPIAK NNPQHLAVYS VSDAVATFYL YDKFIHNFLF
560 570 580 590 600
ALSSIIPMNP DNVLRQGSGT LCEQLLMAEA YRKNILFPNK SKPIYNQYFT
610 620 630 640 650
DPENKKKYFI YDDSFVGGTV QSLKCGIYRD DLKEFFSLDV DTYKYLYNSI
660 670 680 690 700
DHIIDFWIQK DLNKNANIND TKYINKNQII NLDQIKQDIK NKLNFFIENP
710 720 730 740 750
NINICPNIYH LDVAAMYPNI ILSHRLQPNA IITPDHCFNC SFYKQRHLCQ
760 770 780 790 800
KKMIWKRKLE ISPIDYGHVL SLKQDLKTRL FFPQKSFYKM QNKEESDSTE
810 820 830 840 850
NENSMDINAS KKKSWNELTD KQQHDELMKV IKDCSQKVFK KTKVSKEVDA
860 870 880 890 900
SSLVCQRENP FYVDAVKTFR DRRYVYKKGL KECEHEKREL LKQSKIDYIK
910 920 930 940 950
IQELDDKILL NDSLQLAHKC ILNSFYGYVK RRSSRWYSDQ MGAIVTYTGS
960 970 980 990 1000
QIINGAFNLI NKIGIPMELD TDGIWCMLPK NFPEMYDVYI LDKKELNKKK
1010 1020 1030 1040 1050
DYETKSEEEL KNDNNVKKVD FEFPTNILNF EMHKKWTNDQ YLVYNEHTDD
1060 1070 1080 1090 1100
YECISKNEIF FELDGPWHGM FLPASEKSDD LLKKRYVVFN NKYKISELKG
1110 1120 1130 1140 1150
FEIKRRGELR IIQRFQSEIF NHFLKGKTKE ESYYHASLTA NKWKNLIDTK
1160 1170 1180 1190 1200
AIDIDNDDEL FDLILAKKVL NKSVKEQPNA KSFGITTAKR LSELLNNASY
1210 1220 1230 1240 1250
IEDNNVSTQF IVVSKPIGSD ITFRAIPIQI FKTNIDTQIH YLSKWLGTKF
1260 1270 1280 1290 1300
PPNVPVNVRD IIDWDYYKQK LEVQILKLVI IPAIKQNINN PITSISVPDW
1310 1320 1330 1340 1350
LKKQINISEG KQKKITSFFV KKNIKKEDTT SPLHSADVKL VNDIHDFKDS
1360 1370 1380 1390 1400
NETTNTPLHY TQKESMKNKE HISNQSMEKK SPFPIEGENT ITNPSSSILT
1410 1420 1430 1440 1450
QSEETLKNKK RKLIKQYLLD NFISKKQKLI ILYDNNQSNN NNSNIMSGAT
1460 1470 1480 1490 1500
PKTSKLISSV AYKKINSFEN YGENNNNIII IDHEKINISN LKYKDLHNLF
1510 1520 1530 1540 1550
HSNFKNWMLI NNKIWKNNRT QIKKIRIEDK KQKKKNSISF KEQEDEETNK
1560 1570 1580 1590 1600
EKKNYEKISN LDSKYLHTIQ NSMDIVYIYK KIKKKKKNHK KKNANIQLNN
1610 1620 1630 1640 1650
LKNDKQTLLK PYLKYFKHEA NSDSDSNSDD SSSHKKESRN ENYHINEKVD
1660 1670 1680 1690 1700
NNDYYNDDDD DDDDDGIYYA LVSLKNMNKF YKIKIQVYRH IYINNYDQLN
1710 1720 1730 1740 1750
IKSNSKITIK LISSNNDDNG VFKSKAYANC FLPRNIKVFN LYEFIMTEKY
1760 1770 1780 1790 1800
FNQYIINTLN ANYHESIISV YETKIPLYFD FLSRYGNSVE IDSNDYNYIF
1810 1820 1830 1840 1850
DENKCFKSHC FSKVENNSKS TKNVSANYLD DVHIVYIHIF HTLIDNICNR
1860 1870 1880 1890 1900
IFINVYDQFD EHNQDHLLGN KIMFSGIGQK DNNFDPYDTF IKFLQMDKYC
1910 1920 1930 1940 1950
NDNTLNETNK NINMNINSTH DGQNKNILNI NHIHNTFDNN NNNNNDVEYL
1960 1970 1980 1990 2000
NNIEKEKIKK DMLLKNLFNK EFFINSVEKD LLFLYHYRKF DVYYEDNTNV
2010 2020 2030 2040 2050
YKVLEYLDLY LNKYRTNMIT GKQKYIFYVS STIDKKKLGW WATNKYFPCY
2060 2070 2080 2090 2100
FYKFDNTNKY QNVPRLNYQN DIFNLSLNLF FENYHRVEED LNFSRISNIP
2110 2120 2130 2140 2150
LFNLFNVQNK NQKHKFIYDI LYASFIKKYK GILWLSYFGN YDLGIPCLNI
2160 2170 2180 2190 2200
NNFCDYDLAK KNNDIINQGI YRGYIVHLFF NESLIFNSVR LFTKYSNLDK
2210 2220 2230 2240 2250
NTNEYNNTIT NTNTNINNYH NNNIINRNNE HTTFMQNKKK NVKRTLENNT
2260 2270 2280 2290 2300
NHMNKLNNKS NHINKNDSID QKEQLNDEDI STADENNNMN SNNNNNNNNN
2310 2320 2330 2340 2350
NNNNNNNNNN NNNNNNNNNN NNNSVNVNFS SNNDNVIIQS SAELNQKKNL
2360 2370 2380 2390 2400
IQNKYDINSI VERNAHVSQF SNFAFKLLGQ SLEYLISKIS SLSMLITNKT
2410 2420 2430 2440 2450
FESISDIFTS FYSWISNNSS LLYDVALYNK VLECSEIYQN NLINIMKKKF
2460 2470 2480 2490 2500
NANIIFADLR NLVISFNEYS IISGRNILKN LIKYFSHSDS IYANVPFYIK
2510 2520 2530 2540 2550
NEYIAACQFD KYNFIRYKKY SDPNEENTDE NLKIIEYLPP ICESFLRYVL
2560 2570 2580 2590 2600
DIIILNPLHD IILSYDNNKQ NGINPYQSDD QKINHINDIS TCEKNYYNVI
2610 2620 2630 2640 2650
LKNDKLTDKI NLAQKAKLKY IFDKSFDDLE EVCESFSLIN ENVDVLAYKI
2660 2670 2680 2690 2700
EEKLKDLWFM PGIIYKKVKK AIKYKKYLIE NYWPYEDDEI GENNINYAPF
2710 2720 2730 2740 2750
LFPQTLGNLA KRDNNWRLEI VKFCIFLMQN DKLLNLENEN SNEAFHEKRH
2760 2770 2780 2790 2800
ELYEIVGDSE YNKKNSLWKS PCHELILKDI FCDHCSSVYH MNVVTSLVEA
2810 2820 2830 2840 2850
EISGKPSFIW LCKNCNFKFD NEFIELKILS LLQETFDAYN AQDLVCNNCN
2860 2870 2880 2890 2900
AIKSFHRRPI CKCGQIFTPR LEINNWMQTL EIVENLASML NMPLLTDVLT

SMKTHLI
Length:2,907
Mass (Da):344,607
Last modified:September 1, 2009 - v1
Checksum:i9A99570358802385
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844505 Genomic DNA. Translation: CAG25115.1.
RefSeqiXP_966285.1. XM_961192.1.

Genome annotation databases

EnsemblProtistsiCAG25115; CAG25115; PF3D7_0630300.
GeneDBiPF3D7_0630300.1:pep.
GeneIDi3885768.
KEGGipfa:PFF1470c.

Similar proteinsi

Entry informationi

Entry nameiC6KTD8_PLAF7
AccessioniPrimary (citable) accession number: C6KTD8
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: December 20, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported