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C6KTD2

- SET1_PLAF7

UniProt

C6KTD2 - SET1_PLAF7

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Protein

Putative histone-lysine N-methyltransferase 1

Gene

SET1

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Probable histone methyltransferase.By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1671 – 172858PHD-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1761 – 181959PHD-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1764 – 181754RING-type; degenerateSequence AnalysisAdd
BLAST
Zinc fingeri2510 – 257970PHD-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri5557 – 560953PHD-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  2. protein domain specific binding Source: GeneDB_Pfalciparum
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative histone-lysine N-methyltransferase 1 (EC:2.1.1.43)
Short name:
PfSET1
Gene namesi
Name:SET1
ORF Names:PFF1440w
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
ProteomesiUP000001450: Chromosome 6

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0629700.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 67536753Putative histone-lysine N-methyltransferase 1PRO_0000388753Add
BLAST

Proteomic databases

PRIDEiC6KTD2.

Expressioni

Developmental stagei

constitutive pattern of expression.1 Publication

Keywords - Developmental stagei

Merozoite

Interactioni

Protein-protein interaction databases

BioGridi1210423. 12 interactions.
STRINGi5833.PFF1440w-1.

Structurei

3D structure databases

ProteinModelPortaliC6KTD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1832 – 190271BromoPROSITE-ProRule annotationAdd
BLAST
Domaini6612 – 6729118SETPROSITE-ProRule annotationAdd
BLAST
Domaini6737 – 675317Post-SETPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi66 – 63296264Asn-richSequence AnalysisAdd
BLAST
Compositional biasi451 – 575125Lys-richSequence AnalysisAdd
BLAST
Compositional biasi843 – 1091249Lys-richSequence AnalysisAdd
BLAST
Compositional biasi1460 – 1591132Lys-richSequence AnalysisAdd
BLAST
Compositional biasi4196 – 4338143Lys-richSequence AnalysisAdd
BLAST
Compositional biasi5401 – 5520120Lys-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Contains 1 bromo domain.PROSITE-ProRule annotation
Contains 4 PHD-type zinc fingers.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.Sequence Analysis
Contains 1 SET domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1671 – 172858PHD-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1761 – 181959PHD-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1764 – 181754RING-type; degenerateSequence AnalysisAdd
BLAST
Zinc fingeri2510 – 257970PHD-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri5557 – 560953PHD-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Bromodomain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG2940.
InParanoidiC6KTD2.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00297. BROMO. 1 hit.
SM00249. PHD. 4 hits.
SM00508. PostSET. 1 hit.
SM00184. RING. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50014. BROMODOMAIN_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6KTD2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSENSDEGKM QKGKGNEMNE DKIICKKEES NSSSYKFISF IKTIEDVKEK
60 70 80 90 100
WKSSNLSRMD VLKLKNDDIN NDDNMNNMDN MNNMNNMNNI NNMNNMNNIN
110 120 130 140 150
NMNNMNNINN MNNMNNMNNM DNMNNNEKHP CSNNNYSFNN YIKESINYNT
160 170 180 190 200
CTGYDKNNIM LNFLDKHKKS IFLKSRNNVN TFQSDINSSK TSSFFSCMSL
210 220 230 240 250
KNMNYHNDIN KYSNYRMMKN INGLHKLMIL KNKNKDKKLF TNTSDKKNYY
260 270 280 290 300
CLNNGDHIIN EKDSFSDTYI SYGCRKRRWK KKKKNIYNML FYDESINDYP
310 320 330 340 350
YKNLEKTTFS NSSKIYELFF NKYKKKKILN IECSGNKYKG LLRTNHFPPY
360 370 380 390 400
ANFNFTIRRK LQTSNVLGHF MISKCNFNRT ICYRKYIKCV NKYKNNKRNR
410 420 430 440 450
VINMYVKKEN VDSIKGTFGN MNNGVHHNNS RRRLNNTSKN NISNNNNNML
460 470 480 490 500
KKKKGKKNYK GSFDQMIQED TTLDQAKKES IKTVSKNERK NNMNKHSHDN
510 520 530 540 550
KVSKLNKRMS NKRRNNKNCN PSNDMCNEDD VIEKICTTEE VNDDEKKKKL
560 570 580 590 600
SRHKKFVCER KKGVILQNNN KCKKKNDDNI INNNNDDVNN CGDNINDHHD
610 620 630 640 650
NRKDYDTTED QNKCPKILSI NFIKCDEKLF EKIYNDMFLR IGKIVTNKRK
660 670 680 690 700
KYFLIYKIVK DSFFRILILN TEKLEKNILQ VMAVQDVILC DKNVKIYSDP
710 720 730 740 750
IYIRNNNKLY AIKFLKIFSL KYMKKVKNMS EVNFSDDDEC KKENKDNISE
760 770 780 790 800
SSKRSNNIGE KKMLHVEKSE EHDDMTSDSN KEDTKIEEGR KKSNEVNIDV
810 820 830 840 850
DDGEEEENVN NNDNNNDNNN DNDNSSDNNN NDDGSNDTES CSKINKSKYK
860 870 880 890 900
GKEKKDVKEN TDDKNLSDSN SNNSKKKFKV LNKAIKKDND KKKKYEKKNI
910 920 930 940 950
EGNSNNNMIL VRSNSSSTST SNSSSKSKSS NCRNKKNNQI SICSKMDEKN
960 970 980 990 1000
SEQKKKNIKK KNKTCNEGKS KKDSTKLNCV KKVKNKSTDK KNGKSKINIK
1010 1020 1030 1040 1050
NEKKKKINNS KINKGRKGIN KKDKGKGDDN NYVCLIYDDE KKFYFNFKKF
1060 1070 1080 1090 1100
KDIINVIKGS DESTRFYVDT NNNNHNNNMK KKMKLFKKVE KSLYLENLDI
1110 1120 1130 1140 1150
DTDEILFRRP KFFNCIIEES FENYDINYEG EDGNFYVFKN KLNKIRKKVT
1160 1170 1180 1190 1200
IKNETDSSDM YIELKDEEKG FKYIGYRVSF ELKKDNKKKA QVKVGIIKYY
1210 1220 1230 1240 1250
SPKYKQFFIH HLENYKLYQT SDLSKGNNNN NNNNMKENGF VKCGRNSYSR
1260 1270 1280 1290 1300
ACSKSLNSSI YINKYKNVEL NEKITNIIDD DNNNNINSSC IYKNNLSNEN
1310 1320 1330 1340 1350
NLCADKVLCD GNYNMLENDV DEMNNVDQNQ KKRNDLVFSD VKGWYSPYFY
1360 1370 1380 1390 1400
NIKILNNYKE FERFDILEKC DKKKEMTDHV NNTLNKNEIC SICSKRILFM
1410 1420 1430 1440 1450
KGHDHYSCSL SSAIYDMCSE AEKKEIDENN CIDIYWGIKC FTCEKKYHAN
1460 1470 1480 1490 1500
CLEDDVLITK WFDKNILMKE YKKFIYKNSL KKEKRYFNNN GKNKRTKNGK
1510 1520 1530 1540 1550
KKKNTIHKLE DKNNSHVVST ASNSHSIEVS SSESAKKGNE KNTATCKKRK
1560 1570 1580 1590 1600
TSCSALYKKV KKGKNKNGEN KNGENKNGDI KNDDIKNDDI KNDDIRNDDD
1610 1620 1630 1640 1650
KNDENEENTK ECKNESNNID NNNSSNDSLS DVDNNKDNGK SKNKKYRRCI
1660 1670 1680 1690 1700
NYIPSVEHSD ITYKKFICKD CYRCIYCCES IYDYKQTPNV ANYVICKNCN
1710 1720 1730 1740 1750
MVAHGSCCFP NVPDIYLFNW KCDDCLKCNK CNYSNLCYIN YNEWELHLDC
1760 1770 1780 1790 1800
CINCYKEYEK KNFCIMCNEK YDEDDSKKWV QCDVCKFWIH LSCDKNESRN
1810 1820 1830 1840 1850
IETLSNKNID YKCPTCSIGT FHDKIERILY LLFLLDKYKN FTFHVPINYS
1860 1870 1880 1890 1900
IYWRIVKIPM NLYIMKKKIW EKKYDTILDF LYDFMLIIHN AKMVHMPNTP
1910 1920 1930 1940 1950
IYKNACIFEK KGRVIIKNMF NMTNEYLNKC IEDCVENYKN EINNLDSFQI
1960 1970 1980 1990 2000
GHDNNNNNDN NINNNNKMEG VNNESVIFMN DGCNNKLYNK EGTNMTCVNM
2010 2020 2030 2040 2050
DSINKNLNDM NNNNNNNNKM EVFCGQNNIK LNEYYINKEG YNIISNDNNM
2060 2070 2080 2090 2100
NYDNYNNVQN IGMKKMYTNI NDYNSSNVPN ESVYNKENFI NNSSIYNINE
2110 2120 2130 2140 2150
NNTYDLNCDK KLIFDNKYNL SAYQNEGDIM NYNGMYQKNI NISNPPYNNN
2160 2170 2180 2190 2200
NNNNNNMVKE GEKYILNNDD MNNISISKDN DINNNCNNIA NIYRKRKLEQ
2210 2220 2230 2240 2250
YKKDITQYEL YELFDFKNDS FFINRNKEMF SCSSNDHNLI DYNILYVKLN
2260 2270 2280 2290 2300
GKIYFNTFYD KHDEFDVCKI LKVHFLKNNR RGGGNHIMCP KIRNNQNLKE
2310 2320 2330 2340 2350
DVTQCDEEKI EQNNDNGCDD EYDNNNNNNN NIGSSSISSI NKIHMNDTYN
2360 2370 2380 2390 2400
NSINDNSLRH NNNCSVFINS NIFMIDVLNE KVKINNIVKE TKRIISPINN
2410 2420 2430 2440 2450
VLKFLKCIQI VFFYDNNTNE CTEKEKNVIS SNLCNNNFEK YVNINSIDHN
2460 2470 2480 2490 2500
NMSGEKKRKS VEEIMSVVDN KSYYGFNKCS EYILYSSNEY DRAKKKENKR
2510 2520 2530 2540 2550
IKLLKNDILK ECCYICGSIE YKNNFIYCCI CGISVHYSCA NIVHPFLFNL
2560 2570 2580 2590 2600
NDYKDHKKEI NNILNIITRN FKCDNCIKCD NCLLHFDSSL KHNLYFKLKN
2610 2620 2630 2640 2650
LNVSCNNNRM ERRTYNYLYD VKIKVFTTNK EGTKQTGKCV MKTKENDIIK
2660 2670 2680 2690 2700
LDEDNKQKDE LNEANKECFY KQDDVHVEKN CDELLYKNSF NSEECNKNEK
2710 2720 2730 2740 2750
KKNDNNVDEN DDNVDKNDDN NNNNNNGDDN NNIDNTLVDG DMNKLENDLN
2760 2770 2780 2790 2800
NSNDFSINEE KKNNKDTKKY MISSKEEINK EIENVSNQMD NKNNDVDKKK
2810 2820 2830 2840 2850
NISNEEIILD NTKNSCHDND SNVLYNESVK KSFNACKIEK KEGIEKDDNL
2860 2870 2880 2890 2900
GHVNKLRNKR LIKILSIREE GNKLVKCFCC GKPSHDECFY IIDNNTYKNK
2910 2920 2930 2940 2950
ICTLKKTVKN YVRKKNVENK CNTKVEMNSD VILLDDNIKD HCSVNKTGDE
2960 2970 2980 2990 3000
HMNNNEFIDI SKDKISEHNI LDESFNSGVV CSDKNRKDQV VFIDGDVKNN
3010 3020 3030 3040 3050
DISIIEENVT YYTSKEVNNN SVLKNERDVE STSELYIGGD KHVYNKLETD
3060 3070 3080 3090 3100
NAEMESNNNN NNNNNNSDCN NNVSTLSTAA VNTINRSHMS PQKNDNDMNK
3110 3120 3130 3140 3150
INQDDIIHTK MNDKKNVKDD NGNMTNLNNN IDKNDRNLDT ILKEHSVIMQ
3160 3170 3180 3190 3200
KLDELKENRN KEHDGEFYNN LILNNQFLIH SFKVEEGVEI NKDSIIINKK
3210 3220 3230 3240 3250
MFNKYILNKI YELLDNKKRV RIKDLFNLFN LDEFRCSFIL YEVLNALNTY
3260 3270 3280 3290 3300
LNEKLKEYNL TKIRNGTYKK YENEIRNENF CLFNKYLIVN NRDKINITKV
3310 3320 3330 3340 3350
VLKIQSLITE ILSDAMNGNI VDEKDKSKKK ESISSDFNVV NNVKEYNIQN
3360 3370 3380 3390 3400
GCINIDINNY FKGEYINFKP ILCSSQFNLD TNAQIFLQNK ANLSMFQKSA
3410 3420 3430 3440 3450
SYNNNFENNL ENNFVNNKMN NMNNMKNNMN NMNNIMNNIM NNNMNNIMNN
3460 3470 3480 3490 3500
IMNNNMNNII NNNNIFNNDV SNNVDMQHKS DQICIFNSNN IHSVPIFNNK
3510 3520 3530 3540 3550
PYMDNNFNNM VLVNKSNDIN GDDILCNMKN LYNKSVCNKQ EKNGYSVVHK
3560 3570 3580 3590 3600
NICDVNFPYN DTKIWNGDIT NKSKTYTYTN INNNGSVIDY RKWSSVNRSV
3610 3620 3630 3640 3650
SMNNMNCIRS NTNPRILSGT DHILKNNHMN KRNNVNNTYG VNNVNNVNNV
3660 3670 3680 3690 3700
NNTNNVSCFM MRRKIRSNSL HDMNDKMNKM NDNINININN LNIINNNINI
3710 3720 3730 3740 3750
CNMNYPIDRV DSMNNTFNRN NIIISQNTKE NTNILNFNGN DFCNNNNNNN
3760 3770 3780 3790 3800
NIINKENNFG TSNFNSPFHV GNLAKSYSYN NTMSEKNMNE VICPNVRNNM
3810 3820 3830 3840 3850
SNMNNMNNMN NMNNMNNMNN MNNMNNMDSI NNVISYSCTN PNMKDINFNS
3860 3870 3880 3890 3900
MRRSSSTPKK STGLLKNYFN IDIDQYNKTN SHIMNYNVSI NNDMNNVYIN
3910 3920 3930 3940 3950
NNNNHNNNNN NSCNNFINND VINMNNVGTF YNFNQNAESY NNISNNIKCS
3960 3970 3980 3990 4000
NINNIIINNN MNVNNLNYFC NNKEVGFKEN DLNINQKVHT INKDPYEMNH
4010 4020 4030 4040 4050
SKMYVTFPYC NTKDNNSNKS SLKSNVLRLD KIRNRNIKKP LLYNRSSSMH
4060 4070 4080 4090 4100
SSDNLIYNVH NNNRNSPAEF TSDIIINKER NMENNYNTSI NYVNNNITNN
4110 4120 4130 4140 4150
IIVANNNCYH TANNFIQINY SPSSSNIVNI NKDSYKYDIS LENCIDLGST
4160 4170 4180 4190 4200
NTCMYNLNNI HNKDINNMPL EDCFSHIGSC PNEQNEHEDE INEDNKKDVT
4210 4220 4230 4240 4250
KQQKKRKLNS VSKKDMLIKK EMNADDNINC KENTLQNESP KKDDELREND
4260 4270 4280 4290 4300
LKTTTENIKS NEVEDKEFVD KKKKRKLSVK VKVNVNVKVE LQDTENDENK
4310 4320 4330 4340 4350
EKGIKKEKND EEKKNDAEKK KKENKKGREK SVKVRKTKNQ TQVERENEKE
4360 4370 4380 4390 4400
NLMENVTNDK TSDIINNKTS DIINNKTSDI INNKTSDIIN NKTSDIINNK
4410 4420 4430 4440 4450
TSDIINNKTS DIINDKTNDI INNKTSDCLS LVQNNKPVIH IDCNTSLDIT
4460 4470 4480 4490 4500
DGYNNLISCE GRKKGKYNIE ENNINDDNMF QYSDAFDSEG SIKYKEEYDK
4510 4520 4530 4540 4550
IYIPNNKNKI NNINNFLIKN NLLLKSKFMR ITPNTYLCRN CVLLYQNDFS
4560 4570 4580 4590 4600
YNTYEEEINK MERSILNEYE KGVIKKNEYV HDAIQNDKVV NTDENIMTNV
4610 4620 4630 4640 4650
LADKVDDMKI VEKLNCPLNV EEKGIEENIL YVKREGDELI NYGKHNDQMK
4660 4670 4680 4690 4700
EEEESEVVLG DVDFLKNEKK DNLILPYDEK YTGVNNNNSS IIMSLKKCDK
4710 4720 4730 4740 4750
NITKKKGKDK NFNNIKYFKI DNNKSLWYEN YMYWMNKISL YNNLFFTNMY
4760 4770 4780 4790 4800
YKENVIKCID MNNLFLNKMN IYKCSICCML YHCSNMDRNN FFIKNEDKMR
4810 4820 4830 4840 4850
KKTKKNDCLK LLYICNLCTI KYDYVLKIIT YKENNKCWNE FYTDNYYKNN
4860 4870 4880 4890 4900
FYELVYFIIK IIYKNIYINN FFNIFCSIMD NIFKEHKTLN MKLLSLFLFS
4910 4920 4930 4940 4950
NKYFKYEEFY HFFNNKMKKD DRVFKKTFHM KNVCFMPRYS KKSIMYYIFS
4960 4970 4980 4990 5000
LFCNKIYNIN KKKKCIHNKR SYIHNKQSYI HNKRTDVMYD NNVYFHLYEL
5010 5020 5030 5040 5050
ARKKLYDYSE KSQKPFDEII NMCLYLLYLY YLCNVLYKCV RINNVLKGDK
5060 5070 5080 5090 5100
DKGDILCDNK KMKYYKKRKN IKLFLNIINS NEYINVNKIF HGKCIYELPF
5110 5120 5130 5140 5150
YVNKERIKKK RNSVREFINN NDNNQENNAD KKKDHHIYNQ NYNHNSYLCD
5160 5170 5180 5190 5200
IGKVDESLHS KEDNKKDVII TNNASIDSTS PSINMNKSVV SSIYSYNSNK
5210 5220 5230 5240 5250
EKKKNMRKCI KGLHHTIKNK LNLYVKLMLD KYIQESSNYI KNENKDIKKT
5260 5270 5280 5290 5300
IESKNKDDKI CLLCNFSNYI YKGRLIPFYD IYIHSECLKW SLNCTQCCYE
5310 5320 5330 5340 5350
ENKNKTIVNN DNGTKVDVNL DNADDIINNN NMNMLDNNMN GPIKNNEENN
5360 5370 5380 5390 5400
NNNDNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
5410 5420 5430 5440 5450
KSKKNTQKKK DHVNDVKINQ NNSNNKNNKK KKTSKDNEEL KSDNTKNNKT
5460 5470 5480 5490 5500
KDSDGNNNDK TKLEKINLIH NKQSNEISCK IDNNNIINDI STNNPYMKEK
5510 5520 5530 5540 5550
KCKNKEKNRG SKNNNIKNIK LIDMCEWKED RNFYNIYENM IEVDEDNVKE
5560 5570 5580 5590 5600
IIFDSIKSTC FLCGYNNASV YCSNEDCNVK FHLNCAFYST VIKDPSNNPF
5610 5620 5630 5640 5650
FRYLKCFNLV EFNKDTIFYK NMYHDPNVNN SVSSHVCTDN RYYKEMIEKN
5660 5670 5680 5690 5700
YVDIFPVHII YKIKKIWCNK CWNKKKIYNL FYIQKCFMSP YYYDNIKTEE
5710 5720 5730 5740 5750
SVPNKITPMK KDKSDITNEV KEEKDDDILY DSKVHKEYFT LRNILMDDNL
5760 5770 5780 5790 5800
LNNIIRNKKS CSMEIQENND KMKGDNNIDN EDVRNVLCDG EERVSYNRNK
5810 5820 5830 5840 5850
LNDILLKMDM KDILKYFIDF YFENGSYYIL DNILYSVNHC VKIKYKKKSL
5860 5870 5880 5890 5900
YNIQDVLNKE TKIGTMMREL EGLISKYVNR SNDNNYMDRK YDMLLLKNIK
5910 5920 5930 5940 5950
SDINNDNNND INNNDNNNNE NNNENINDNN NNNNNNNNNN NNNNSNNNNN
5960 5970 5980 5990 6000
NNYYYYHNNE GKYNEQGSYQ HIDIQNIIND KSVENLIKGY FILKNFLHIG
6010 6020 6030 6040 6050
NNNITLQNED LLILKKSENS FVHNLYDNDK VYNVHVPYVY TKKMNTSYMN
6060 6070 6080 6090 6100
KKENDKKYNK SVNKNSCKSK NSILDNINFD KNKNKITKKY TAFIIDNNEY
6110 6120 6130 6140 6150
TTDCSNEENN TSDDEENENR KNENDDDNIP EHIKMNNIMN SQQKKENDFK
6160 6170 6180 6190 6200
NINLYFQLTN VIKKVSINKL EGNFFNYEEK GNLLGSNVSK IKMNELLECN
6210 6220 6230 6240 6250
VGEENFCDDD QKFSDNKNYA SDDEEKKKKK RKNQTRFYNY PKRISTTNNN
6260 6270 6280 6290 6300
KNVNVLVNSL NNNLINKKEY FLNIIMNENN DLYMKKINEK YFPNYHPKKR
6310 6320 6330 6340 6350
KKKKLDNTSY INHNYNYNYP YNYNLLSNNS KSRILKVGCH NILNIGDILK
6360 6370 6380 6390 6400
YDGDKIIYPC GYLNMRIFYN LPSYYLFQIY KNANIDDINR KTKLLEKIFL
6410 6420 6430 6440 6450
QLRATYIFSI TLREQNFFFS ILLFPLINID YFSESDATNF ILAEGYNINE
6460 6470 6480 6490 6500
VYMKFLSLFN SQNYICDDMN NDYSHYNAKY GNIYKCLETY ILKSVEHNKF
6510 6520 6530 6540 6550
IDSHTFFGLT LPCVVYQIKY KLFKYMYKHL SEKIKTYIKK SKDSVMKKRI
6560 6570 6580 6590 6600
KGCTREVVYN DNVLCKYSNL DTTIFKENEK ENEKNIRKTV KYKYNINSAM
6610 6620 6630 6640 6650
SYRYLMNISS NLRLYVKKSS IHGYGLYTCE FINEGEPVIE YIGEYIRNII
6660 6670 6680 6690 6700
SDKREKYYDK IESSCYMFRL NENIIIDATK WGNVSRFINH SCEPNCFCKI
6710 6720 6730 6740 6750
VSCDQNLKHI VIFAKRDIAA HEEITYDYQF GVESEGKKLI CLCGSSTCLG

RMN
Length:6,753
Mass (Da):796,045
Last modified:September 1, 2009 - v1
Checksum:iEF689CABCFA20F00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844505 Genomic DNA. Translation: CAG25109.2.
RefSeqiXP_966279.2. XM_961186.2.

Genome annotation databases

EnsemblProtistsiPFF1440w:mRNA; PFF1440w:pep; PFF1440w.
GeneIDi3885750.
KEGGipfa:PFF1440w.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844505 Genomic DNA. Translation: CAG25109.2 .
RefSeqi XP_966279.2. XM_961186.2.

3D structure databases

ProteinModelPortali C6KTD2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 1210423. 12 interactions.
STRINGi 5833.PFF1440w-1.

Proteomic databases

PRIDEi C6KTD2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi PFF1440w:mRNA ; PFF1440w:pep ; PFF1440w .
GeneIDi 3885750.
KEGGi pfa:PFF1440w.

Organism-specific databases

EuPathDBi PlasmoDB:PF3D7_0629700.

Phylogenomic databases

eggNOGi COG2940.
InParanoidi C6KTD2.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR001487. Bromodomain.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00297. BROMO. 1 hit.
SM00249. PHD. 4 hits.
SM00508. PostSET. 1 hit.
SM00184. RING. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEi PS50014. BROMODOMAIN_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7.
  2. "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13."
    Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., Christodoulou Z.
    , Clark L., Clark R., Corton C., Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., Sulston J.E., Craig A., Newbold C., Barrell B.G.
    Nature 419:527-531(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7.
  3. "Rapid identification of malaria vaccine candidates based on alpha-helical coiled coil protein motif."
    Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I., Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F., Baecker V., Druilhe P., Kajava A.V., Corradin G.
    PLoS ONE 2:E645-E645(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SYNTHESIS OF 3412-3441, POSSIBLE CANDIDATE MALARIA EPITOPE.
  4. "Histone lysine methyltransferases and demethylases in Plasmodium falciparum."
    Cui L., Fan Q., Cui L., Miao J.
    Int. J. Parasitol. 38:1083-1097(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiSET1_PLAF7
AccessioniPrimary (citable) accession number: C6KTD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: September 1, 2009
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

Possible candidate for an effective malaria vaccine as determined by epitope response in sera.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3