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Protein

Merozoite surface protein P12

Gene

PF12

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • entry into host cell Source: GeneDB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Merozoite surface protein P12
Cleaved into the following chain:
Gene namesi
Name:PF12
ORF Names:PFF0615c
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0612700.

Subcellular locationi

Merozoite surface protein P12 :
Merozoite surface protein P12, processed form :

GO - Cellular componenti

  • anchored component of plasma membrane Source: GeneDB
  • apical part of cell Source: GeneDB
  • cell surface Source: GeneDB
  • symbiont-containing vacuolar space Source: GeneDB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Parasites grow at normal rates in vitro.1 Publication

Keywords - Diseasei

Malaria

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000042355726 – 322Merozoite surface protein P12Add BLAST297
ChainiPRO_000042355826 – ?Merozoite surface protein P12, processed form
PropeptideiPRO_0000423559323 – 347Removed in mature formSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi31 ↔ 531 Publication
Disulfide bondi67 ↔ 1381 Publication
Disulfide bondi81 ↔ 1361 Publication
Glycosylationi147N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi179 ↔ 2111 Publication
Glycosylationi200N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi225 ↔ 2861 Publication
Glycosylationi228N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi236 ↔ 2841 Publication
Glycosylationi242N-linked (GlcNAc...)Sequence analysis1
Glycosylationi265N-linked (GlcNAc...)Sequence analysis1
Lipidationi322GPI-anchor amidated asparagineSequence analysis1
Glycosylationi322N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Processed into a soluble form.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

PTM databases

SwissPalmiC6KSX0.

Expressioni

Developmental stagei

Specifically present in asexual blood stage parasites. First detected in the trophozoite stage, 30-40 hours post-invasion (HPI) and the proteins reaches peak expression in schizont stage, 40-48 HPI.2 Publications

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with PF41. May form an antiparallel heterodimer with PF41.

Structurei

Secondary structure

1347
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 32Combined sources3
Turni33 – 36Combined sources4
Beta strandi50 – 55Combined sources6
Beta strandi62 – 66Combined sources5
Beta strandi70 – 72Combined sources3
Beta strandi75 – 78Combined sources4
Beta strandi119 – 123Combined sources5
Beta strandi134 – 140Combined sources7
Beta strandi161 – 167Combined sources7
Beta strandi176 – 180Combined sources5
Beta strandi187 – 192Combined sources6
Helixi195 – 198Combined sources4
Beta strandi209 – 215Combined sources7
Beta strandi220 – 224Combined sources5
Beta strandi230 – 233Combined sources4
Beta strandi239 – 245Combined sources7
Beta strandi247 – 249Combined sources3
Beta strandi257 – 262Combined sources6
Turni263 – 266Combined sources4
Beta strandi267 – 271Combined sources5
Beta strandi274 – 276Combined sources3
Beta strandi280 – 287Combined sources8
Beta strandi294 – 300Combined sources7
Beta strandi302 – 304Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YMOX-ray1.90A28-304[»]
ProteinModelPortaliC6KSX0.
SMRiC6KSX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 1726-Cys 1Add BLAST146
Domaini175 – 3056-Cys 2Add BLAST131

Sequence similaritiesi

Contains 2 6-Cys domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOGENOMiHOG000281492.
InParanoidiC6KSX0.
PhylomeDBiC6KSX0.

Family and domain databases

InterProiIPR010884. 6_CYS_dom.
[Graphical view]
PfamiPF07422. s48_45. 2 hits.
[Graphical view]
SMARTiSM00970. s48_45. 2 hits.
[Graphical view]
PROSITEiPS51701. 6_CYS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C6KSX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKLSKKYCL GISFVLYILL SVCEGHKNLT CDFNDVYKLE FHPNQQTSVT
60 70 80 90 100
KLCNLTPNVL EKVTIKCGSD KLNYNLYPPT CFEEVYASRN MMHLKKIKEF
110 120 130 140 150
VIGSSMFMRR SLTPNKINEV SFRIPPNMMP EKPIYCFCEN KKTITINGSN
160 170 180 190 200
GNPSSKKDII NRGIVEIIIP SLNEKVKGCD FTTSESTIFS KGYSINEISN
210 220 230 240 250
KSSNNQQDIV CTVKAHANDL IGFKCPSNYS VEPHDCFVSA FNLSGKNENL
260 270 280 290 300
ENKLKLTNII MDHYNNTFYS RLPSLISDNW KFFCVCSKDN EKKLVFTVEA
310 320 330 340
SISSSNTKLA SRDNTYQDYI SNSSFLTLSS YCAFITFIIT SFLSFIL
Length:347
Mass (Da):39,434
Last modified:September 1, 2009 - v1
Checksum:i0950614A8565DEA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844505 Genomic DNA. Translation: CAG25366.1.
RefSeqiXP_966114.1. XM_961021.1.

Genome annotation databases

EnsemblProtistsiCAG25366; CAG25366; PF3D7_0612700.
GeneDBiPF3D7_0612700.1:pep.
GeneIDi3885775.
KEGGipfa:PFF0615c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844505 Genomic DNA. Translation: CAG25366.1.
RefSeqiXP_966114.1. XM_961021.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YMOX-ray1.90A28-304[»]
ProteinModelPortaliC6KSX0.
SMRiC6KSX0.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

SwissPalmiC6KSX0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAG25366; CAG25366; PF3D7_0612700.
GeneDBiPF3D7_0612700.1:pep.
GeneIDi3885775.
KEGGipfa:PFF0615c.

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0612700.

Phylogenomic databases

HOGENOMiHOG000281492.
InParanoidiC6KSX0.
PhylomeDBiC6KSX0.

Family and domain databases

InterProiIPR010884. 6_CYS_dom.
[Graphical view]
PfamiPF07422. s48_45. 2 hits.
[Graphical view]
SMARTiSM00970. s48_45. 2 hits.
[Graphical view]
PROSITEiPS51701. 6_CYS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPF12_PLAF7
AccessioniPrimary (citable) accession number: C6KSX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: September 1, 2009
Last modified: November 2, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

Does not have erythrocyte-receptor-binding ability.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.