C6HSY3 (AMPP1_AJECH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase P
Short name=AMPP
Short name=Aminopeptidase P
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	AMPP
ORF Names:	HCDG_09314

Organism

Ajellomyces capsulata (strain H143) (Darling's disease fungus) (Histoplasma capsulatum) [Complete proteome]

Taxonomic identifier

544712 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › Ajellomycetaceae › Ajellomyces › Ajellomyces capsulatus

Protein attributes

Sequence length	636 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 636	636	Probable Xaa-Pro aminopeptidase P		PRO_0000411771
Sites
	Metal binding	414	1	Manganese 2 By similarity
	Metal binding	425	1	Manganese 1 By similarity
	Metal binding	425	1	Manganese 2 By similarity
	Metal binding	523	1	Manganese 1 By similarity
	Metal binding	537	1	Manganese 1 By similarity
	Metal binding	537	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	C6HSY3 [UniParc]. Last modified September 1, 2009. Version 1. Checksum: B35B61DD67003A6A	FASTA	636	71,096
	10 20 30 40 50 60 MGPIDTSQRL ARLRELMQER KVDVYVVPSE DSHQSEYIAH CDGRREFISG FTGSAGCAIV 70 80 90 100 110 120 SMTKAALSTD GRYFNQAAKQ LDNNWILLKR GFENMPTWQE WTAEQAEGGK VVGVDPSLIT 130 140 150 160 170 180 ASDARNLSET IKKCGGSLLG VQENLVDLVW GAERPARPSE KVALHPIEFA GKSFEEKISD 190 200 210 220 230 240 LRKELQKKKC AGFVISMLDE IAWLFNLRGN DIPYNPVFFA YAIITQSTAD LYIDEEKLPA 250 260 270 280 290 300 EVKNYLGDKV SLKPYSSIFE DAKVLGQSAQ NKSDGETSTK PPQKFLISTR ASWSLSLALG 310 320 330 340 350 360 GEKNVEEVRS PITDAKAIKN EAELEGMRAC HIRDGAALSE YFAWLENELV NKKTVLNEVD 370 380 390 400 410 420 ASDKLEQIRS KHQHFVGLSF DTISSTGPNA AVIHYKAERN NCSIIDPKAV YLCDSGAQYL 430 440 450 460 470 480 DGTTDTTRTL HFGEPTEMEK KAYTLVLKGL ISIDTAVFPK GTTGFALDAF ARQYLWKEGL 490 500 510 520 530 540 DYLHGTGHGV GSYLNVHEGP IGLGTRVQYS EVAIAPGNVI SDEPGYYEDG VFGIRIESPF 550 560 570 580 590 600 FPHLLINLPF LLTPIIDIIM AKEVKTTHKF GEKPWLGFEH VTMTPLCQKL INPSLLSDVE 610 620 630 KKWVNDYHTE IWEKTSKYFE NDELTRNWLK RETQPI

References

[1]

"The genome sequence of Ajellomyces capsulatus strain H143." Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J. , Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W. Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: H143.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GG692439 Genomic DNA. Translation: EER36658.1.
3D structure databases
ProteinModelPortal	C6HSY3.
ModBase	Search...
Protein family/group databases
MEROPS	M24.003.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.90.230.10. 2 hits.
InterPro	IPR000587. Creatinase. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF01321. Creatinase_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP1_AJECH

Accession

Primary (citable) accession number: C6HSY3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	September 1, 2009
Last modified:	March 6, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program