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C6HRC7

- DAPB_AJECH

UniProt

C6HRC7 - DAPB_AJECH

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Protein

Probable dipeptidyl-aminopeptidase B

Gene
DAPB, HCDG_08512
Organism
Ajellomyces capsulatus (strain H143) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei756 – 7561Charge relay system By similarity
Active sitei833 – 8331Charge relay system By similarity
Active sitei866 – 8661Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:HCDG_08512
OrganismiAjellomyces capsulatus (strain H143) (Darling's disease fungus) (Histoplasma capsulatum)
Taxonomic identifieri544712 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
ProteomesiUP000002624: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9999Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei100 – 12021Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini121 – 917797Vacuolar Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 917917Probable dipeptidyl-aminopeptidase BPRO_0000412125Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi135 – 1351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi351 – 3511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi574 – 5741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi815 – 8151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi902 – 9021N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliC6HRC7.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi64 – 8320Asp-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

C6HRC7-1 [UniParc]FASTAAdd to Basket

« Hide

MATEKGHGRD DEERVPLTRG STEFRNSIDS FDYSSSTASL SLAVIDRINN    50
STQDAALGEK GPRDDDDDRY WDDDVEYDVE DADYIPSGGK PMHKSVKIAL 100
WTLLFLSLGG WSLAFVLFIF RSHDTYETPI SSEDNISSGG LRGDRITLDD 150
VLGEEWMPRH HFISWFPGPN GEDGLLLEKD GLGSTGYLRV EDIVSRKDTK 200
SSKGSIVLMQ KNTFTVGGET VICSQVWPSP DLKTVLVLSE KKQNWRHSFT 250
GKYWLFDVDT QTGQPLDPAA QDQRIQLASW SPQSDAVVFT RDNNMFLRKL 300
SSKEVTTITS DGGVDLFYGV PDWVYEEEVF SGNSATWWAH DGNYIAFLRT 350
NESAVPEYPV QYFVSRPSGE DPNLGEENYP EVREIKYPKA GAPNPIVDLQ 400
FYDVRKGEIF SVDVADRFPD DYRLIIEVLW ASNGKILVRE TNRESDILII 450
AAIDVLSRTG KIVRKEDINA LDGGWVEPTQ STRFIPADPS NGRPEDGYID 500
TVIHEGRDQL AYFTPLDNPK PLILTKGPSE IVNSPSGVDL KRGLVYFVVA 550
GNEPWERHVY SVKFDGTALQ PVTNVSESSY YDVSFSDGAG YALLNFQGPK 600
VPWQKVISTP ANENPFEEII EQNNHLSRKL RLFSLESKVF QYINIDGFSL 650
PVLERRPPNF DPTKKYPVLF YLYGGPGSQT VDKKFRVDFQ SYVASTLGYI 700
VVTVDGRGTG YIGRKSRSIV RGKLGHYEAR DQIEVAKKWA AKPYVDESRM 750
AIWGWSYGGF MTLKTIEEDG GRTFQYGMAV APVTDWRYYD SIYAERYMHT 800
PQHNPQGYDS SAISNTTALA NNVRFLVMHG TADDNVHIQN TLTLLDKLDL 850
ANVDNYDVHV FPDSNHNINF HNAHKIVYTR LADWLVNAFN GQWLKTNNPT 900
PNDSLFRRAA TWAGLSI 917
Length:917
Mass (Da):103,412
Last modified:September 1, 2009 - v1
Checksum:i0C1A7AD5D755FFC9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG692436 Genomic DNA. Translation: EER37061.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG692436 Genomic DNA. Translation: EER37061.1 .

3D structure databases

ProteinModelPortali C6HRC7.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: H143.

Entry informationi

Entry nameiDAPB_AJECH
AccessioniPrimary (citable) accession number: C6HRC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: September 1, 2009
Last modified: June 11, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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