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C6HRC7 (DAPB_AJECH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:DAPB
ORF Names:HCDG_08512
OrganismAjellomyces capsulatus (strain H143) (Darling's disease fungus) (Histoplasma capsulatum) [Complete proteome]
Taxonomic identifier544712 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces

Protein attributes

Sequence length917 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Ontologies

Keywords
   Cellular componentMembrane
Vacuole
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionAminopeptidase
Hydrolase
Protease
Serine protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

vacuolar membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaminopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 917917Probable dipeptidyl-aminopeptidase B
PRO_0000412125

Regions

Topological domain1 – 9999Cytoplasmic Potential
Transmembrane100 – 12021Helical; Signal-anchor for type II membrane protein; Potential
Topological domain121 – 917797Vacuolar Potential
Compositional bias64 – 8320Asp-rich

Sites

Active site7561Charge relay system By similarity
Active site8331Charge relay system By similarity
Active site8661Charge relay system By similarity

Amino acid modifications

Glycosylation1351N-linked (GlcNAc...) Potential
Glycosylation3511N-linked (GlcNAc...) Potential
Glycosylation5741N-linked (GlcNAc...) Potential
Glycosylation8151N-linked (GlcNAc...) Potential
Glycosylation9021N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
C6HRC7 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: 0C1A7AD5D755FFC9

FASTA917103,412
        10         20         30         40         50         60 
MATEKGHGRD DEERVPLTRG STEFRNSIDS FDYSSSTASL SLAVIDRINN STQDAALGEK 

        70         80         90        100        110        120 
GPRDDDDDRY WDDDVEYDVE DADYIPSGGK PMHKSVKIAL WTLLFLSLGG WSLAFVLFIF 

       130        140        150        160        170        180 
RSHDTYETPI SSEDNISSGG LRGDRITLDD VLGEEWMPRH HFISWFPGPN GEDGLLLEKD 

       190        200        210        220        230        240 
GLGSTGYLRV EDIVSRKDTK SSKGSIVLMQ KNTFTVGGET VICSQVWPSP DLKTVLVLSE 

       250        260        270        280        290        300 
KKQNWRHSFT GKYWLFDVDT QTGQPLDPAA QDQRIQLASW SPQSDAVVFT RDNNMFLRKL 

       310        320        330        340        350        360 
SSKEVTTITS DGGVDLFYGV PDWVYEEEVF SGNSATWWAH DGNYIAFLRT NESAVPEYPV 

       370        380        390        400        410        420 
QYFVSRPSGE DPNLGEENYP EVREIKYPKA GAPNPIVDLQ FYDVRKGEIF SVDVADRFPD 

       430        440        450        460        470        480 
DYRLIIEVLW ASNGKILVRE TNRESDILII AAIDVLSRTG KIVRKEDINA LDGGWVEPTQ 

       490        500        510        520        530        540 
STRFIPADPS NGRPEDGYID TVIHEGRDQL AYFTPLDNPK PLILTKGPSE IVNSPSGVDL 

       550        560        570        580        590        600 
KRGLVYFVVA GNEPWERHVY SVKFDGTALQ PVTNVSESSY YDVSFSDGAG YALLNFQGPK 

       610        620        630        640        650        660 
VPWQKVISTP ANENPFEEII EQNNHLSRKL RLFSLESKVF QYINIDGFSL PVLERRPPNF 

       670        680        690        700        710        720 
DPTKKYPVLF YLYGGPGSQT VDKKFRVDFQ SYVASTLGYI VVTVDGRGTG YIGRKSRSIV 

       730        740        750        760        770        780 
RGKLGHYEAR DQIEVAKKWA AKPYVDESRM AIWGWSYGGF MTLKTIEEDG GRTFQYGMAV 

       790        800        810        820        830        840 
APVTDWRYYD SIYAERYMHT PQHNPQGYDS SAISNTTALA NNVRFLVMHG TADDNVHIQN 

       850        860        870        880        890        900 
TLTLLDKLDL ANVDNYDVHV FPDSNHNINF HNAHKIVYTR LADWLVNAFN GQWLKTNNPT 

       910 
PNDSLFRRAA TWAGLSI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GG692436 Genomic DNA. Translation: EER37061.1.

3D structure databases

ProteinModelPortalC6HRC7.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS09.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
InterProIPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_AJECH
AccessionPrimary (citable) accession number: C6HRC7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: September 1, 2009
Last modified: April 16, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries