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C6HI66

- MAP2_AJECH

UniProt

C6HI66 - MAP2_AJECH

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Protein
Methionine aminopeptidase 2
Gene
HCDG_06216
Organism
Ajellomyces capsulatus (strain H143) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) By similarity.UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei192 – 1921Substrate By similarity
Metal bindingi213 – 2131Divalent metal cation 1 By similarity
Metal bindingi224 – 2241Divalent metal cation 1 By similarity
Metal bindingi224 – 2241Divalent metal cation 2; catalytic By similarity
Metal bindingi293 – 2931Divalent metal cation 2; catalytic; via tele nitrogen By similarity
Binding sitei301 – 3011Substrate By similarity
Metal bindingi326 – 3261Divalent metal cation 2; catalytic By similarity
Metal bindingi421 – 4211Divalent metal cation 1 By similarity
Metal bindingi421 – 4211Divalent metal cation 2; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2 (EC:3.4.11.18)
Short name:
MAP 2
Short name:
MetAP 2
Alternative name(s):
Peptidase M
Gene namesi
ORF Names:HCDG_06216
OrganismiAjellomyces capsulatus (strain H143) (Darling's disease fungus) (Histoplasma capsulatum)
Taxonomic identifieri544712 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
ProteomesiUP000002624: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440Methionine aminopeptidase 2UniRule annotation
PRO_0000407640Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliC6HI66.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi50 – 589Poly-LysUniRule annotation

Sequence similaritiesi

Phylogenomic databases

OrthoDBiEOG7BGHW3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPiMF_03175. MetAP_2_euk.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 2 hits.
TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.
PROSITEiPS01202. MAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6HI66-1 [UniParc]FASTAAdd to Basket

« Hide

MGSKTPGNHR RDPNESSRPP AIDAINPPKQ AAASGLVHGS LEGESQKRNK    50
RKKKKKKKNT KELEILQTTP PRVALANIFR SQRYPEAEIV KYSSDNDNLQ 100
RTTAEELRHL SVLNAMDDEF LNDYRNAAEV HRQVRQYVQT IIKPGIALSQ 150
LAQEIEDGVR ALTNHQGLET GDALKAGMAF PTGLCLNNIA AHWTPNPGAK 200
EVILQYDDVL KIDFGVHVNG RIVDSAFTMA FNPVYDNLLA AVKNATNTGL 250
KEAGIDARIA HISETIQEVM ESYEVELNRK VIPVKAVRNI TGHNILHYKI 300
HGDKQVPFVK TQTNQRMEEG DVFAIETFGS TGKAYLDDAT GIYGYGYDEN 350
ASTAGLHHSS AKSLLKTIKE NFGTLVFSRR YLERLGVQRY HLGMRSLVTN 400
GIVQSYAPLV DVPGSYVAQF EHTVLLRPNC KEVISRGDDY 440
Length:440
Mass (Da):48,946
Last modified:September 1, 2009 - v1
Checksum:i182797C03B39361E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG692428 Genomic DNA. Translation: EER39994.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG692428 Genomic DNA. Translation: EER39994.1 .

3D structure databases

ProteinModelPortali C6HI66.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG7BGHW3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPi MF_03175. MetAP_2_euk.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 2 hits.
TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
PROSITEi PS01202. MAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: H143.

Entry informationi

Entry nameiMAP2_AJECH
AccessioniPrimary (citable) accession number: C6HI66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: September 1, 2009
Last modified: June 11, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi