C6GXE6 (C6GXE6_STRS4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
dTDP-glucose 4,6-dehydratase RuleBase RU004473
EC=4.2.1.46 RuleBase RU004473

Gene names

Name:	rmlB EMBL CAZ55493.1
Ordered Locus Names:	SSUBM407_0659 EMBL CAZ55493.1

Organism

Streptococcus suis (strain BM407) [Complete proteome] [HAMAP] EMBL CAZ55493.1

Taxonomic identifier

568814 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus suis

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O. RuleBase RU004473
Cofactor	NAD By similarity. RuleBase RU004473
Sequence similarities	Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily. RuleBase RU004473

Ontologies

Keywords
Molecular function	Lyase RuleBase RU004473 EMBL CAZ55493.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	nucleotide-sugar metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	coenzyme binding Inferred from electronic annotation. Source: InterPro dTDP-glucose 4,6-dehydratase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C6GXE6 [UniParc]. Last modified September 1, 2009. Version 1. Checksum: EEA3464D7CBCF2A1	FASTA	348	38,932
	10 20 30 40 50 60 MSQFKNIIVT GGAGFIGSNF VHYVYNNHPD VHVTVLDKLT YAGNKANLEA ILGDRVELVV 70 80 90 100 110 120 GDIADAELVD KLAAKADAIV HYAAESHNDN SLNDPSPFIH TNFIGTYTLL EAARKYDIRF 130 140 150 160 170 180 HHVSTDEVYG DLPLREDLPG HGEGPGEKFT AETNYNPSSP YSSTKAASDL IVKAWVRSFG 190 200 210 220 230 240 VKATISNCSN NYGPYQHIEK FIPRQITNIL AGIKPKLYGE GKNVRDWIHT NDHSTGVWAI 250 260 270 280 290 300 LTKGRMGETY LIGADGEKNN KEVLELILEK MGQPKDAYDH VTDRAGHDLR YAIDASKLRD 310 320 330 340 ELGWTPQFTD FSQGLEETIQ WYTDNQDWWK AEKEAVEANY AKTQEVIK

References

[1]

"Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis." Holden M.T.G., Hauser H., Sanders M., Ngo T.H., Cherevach I., Cronin A., Goodhead I., Mungall K., Quail M.A., Price C., Rabbinowitsch E., Sharp S., Croucher N.J., Chieu T.B., Mai N.T.H., Diep T.S., Chinh N.T., Kehoe M. , Leigh J.A., Ward P.N., Dowson C.G., Whatmore A.M., Chanter N., Iversen P., Gottschalk M., Slater J.D., Smith H.E., Spratt B.G., Xu J., Ye C., Bentley S.D., Barrell B.G., Schultsz C., Maskell D.J., Parkhill J. PLoS ONE 4:e6072-e6072(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BM407 EMBL CAZ55493.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM252032 Genomic DNA. Translation: CAZ55493.1.
RefSeq	YP_003028418.1. NC_012926.1.
3D structure databases
ProteinModelPortal	C6GXE6.
ModBase	Search...
Protein-protein interaction databases
STRING	568814.SSUBM407_0659.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAZ55493; CAZ55493; SSUBM407_0659.
GeneID	8153488.
KEGG	ssb:SSUBM407_0659.
PATRIC	19782087. VBIStrSui1141_0684.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1088.
HOGENOM	HOG000168006.
KO	K01710.
OMA	HEDWWKA.
ProtClustDB	CLSK877134.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR005888. dTDP_Gluc_deHydtase. IPR001509. Epimerase_deHydtase. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR10366:SF41. PTHR10366:SF41. 1 hit.
Pfam	PF01370. Epimerase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01181. dTDP_gluc_dehyt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C6GXE6_STRS4

Accession

Primary (citable) accession number: C6GXE6

Entry history

Integrated into UniProtKB/TrEMBL:	September 1, 2009
Last sequence update:	September 1, 2009
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)