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C6GUJ1 (C6GUJ1_STRS4) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyl phosphate reductase HAMAP-Rule MF_00412
Short name=GPR HAMAP-Rule MF_00412
EC=1.2.1.41 HAMAP-Rule MF_00412
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase HAMAP-Rule MF_00412
Glutamyl-gamma-semialdehyde dehydrogenase HAMAP-Rule MF_00412
Gene names
Name:proA HAMAP-Rule MF_00412 EMBL CAZ56161.1
Ordered Locus Names:SSUBM407_1304 EMBL CAZ56161.1
OrganismStreptococcus suis (strain BM407) [Complete proteome] [HAMAP] EMBL CAZ56161.1
Taxonomic identifier568814 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity. HAMAP-Rule MF_00412 SAAS SAAS020593

Catalytic activity

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP-Rule MF_00412 SAAS SAAS020593

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP-Rule MF_00412 SAAS SAAS020593

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00412 SAAS SAAS020593.

Sequence similarities

Belongs to the gamma-glutamyl phosphate reductase family. HAMAP-Rule MF_00412

Sequences

Sequence LengthMass (Da)Tools
C6GUJ1 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: C688B33D7A3CFB64

FASTA41243,863
        10         20         30         40         50         60 
MTTTQVLLDS LLANKASINL ATTEQKNQAL SAMADQLVAQ TEAILAGNAI DMEHAQGKIS 

        70         80         90        100        110        120 
QVMQDRLLLT EERIEAMADG IRALIGLPDP VGLVLEESTR ADGLNICKKS IPFGLVGMIY 

       130        140        150        160        170        180 
ESRPNVTSDA AALAIKSGNA VILRGGKEAF HSAKAIVTAL KSGLEEAGVS PKVIELVQDT 

       190        200        210        220        230        240 
SRVSATELMT AKGKIDLLVP RGGAGLIQAV VENATVPVIE TGTGICHVYV DKDADLDKAL 

       250        260        270        280        290        300 
RIVVNAKTSR PSVCNAAEVL LVHEEIASQF LPRLEEALSG QVELRADSQA QALLNQARPA 

       310        320        330        340        350        360 
GDQDFDTEFL DYIMAVKVVS SVEEAISHIA QHSTGHSEAI VTENSQTAEH FTLHVDSAAV 

       370        380        390        400        410 
YVNASTRFTD GGEFGLGCEL GISTQKMHAR GPMGLREMTT YKYIITGDGH IR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM252032 Genomic DNA. Translation: CAZ56161.1.
RefSeqYP_003029016.1. NC_012926.1.

3D structure databases

ProteinModelPortalC6GUJ1.
ModBaseSearch...

Protein-protein interaction databases

STRING568814.SSUBM407_1304.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAZ56161; CAZ56161; SSUBM407_1304.
GeneID8153569.
KEGGssb:SSUBM407_1304.
PATRIC19783405. VBIStrSui1141_1340.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0014.
HOGENOMHOG000246356.
KOK00147.
OMAEVGISTQ.
ProtClustDBPRK00197.

Enzyme and pathway databases

UniPathwayUPA00098; UER00360.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPMF_00412. ProA.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
PANTHERPTHR11063:SF1. PTHR11063:SF1. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFPIRSF000151. GPR. 1 hit.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00407. proA. 1 hit.
PROSITEPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC6GUJ1_STRS4
AccessionPrimary (citable) accession number: C6GUJ1
Entry history
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: May 1, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info