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C6GRB1

- C6GRB1_STRSX

UniProt

C6GRB1 - C6GRB1_STRSX

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Protein
Gamma-glutamyl phosphate reductase
Gene
proA, SSUSC84_0494
Organism
Streptococcus suis (strain SC84)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity.UniRule annotationSAAS annotations

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotationSAAS annotations

Pathwayi

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. glutamate-5-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

NADPUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciSSUI568813:GJFC-555-MONOMER.
UniPathwayiUPA00098; UER00360.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
Short name:
GPRUniRule annotation
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase
Glutamyl-gamma-semialdehyde dehydrogenase
Gene namesi
Name:proAUniRule annotationImported
Ordered Locus Names:SSUSC84_0494Imported
OrganismiStreptococcus suis (strain SC84)Imported
Taxonomic identifieri568813 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002738: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Protein-protein interaction databases

STRINGi568813.SSUSC84_0494.

Structurei

3D structure databases

ProteinModelPortaliC6GRB1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0014.
HOGENOMiHOG000246356.
KOiK00147.
OMAiALTSYKW.
OrthoDBiEOG6FFSCX.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPiMF_00412. ProA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF000151. GPR. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00407. proA. 1 hit.
PROSITEiPS01223. PROA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6GRB1-1 [UniParc]FASTAAdd to Basket

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MTTTQVLLDS LLANKASINL ATTEQKNQAL SAMADQLVAQ TEAILAGNAI    50
DMEHAQGKIS QVMQDRLLLT EERIEAMADG IRALIGLPDP VGLVLEESTR 100
ADGLNICKKS IPFGLVGMIY ESRPNVTSDA AALAIKSGNA VILRGGKEAF 150
HSAKAIVTAL KSGLEEAGVS PKVIELVQDT SRVSATELMT AKGKIDLLVP 200
RGGAGLIQAV VENATVPVIE TGTGICHVYV DKDADLDKAL RIVVNAKTSR 250
PSVCNAAEVL LVHEEIASQF LPRLEEALSG QVELRADSQA QALLNQARPA 300
GDQDFDTEFL DYIMAVKVVS SVEEAISHIA QHSTGHSEAI VTENSQTAEH 350
FTLHVDSAAV YVNASTRFTD GGEFGLGCEL GISTQKMHAR GPMGLREMTT 400
YKYIITGDGH IR 412
Length:412
Mass (Da):43,863
Last modified:September 1, 2009 - v1
Checksum:iC688B33D7A3CFB64
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM252031 Genomic DNA. Translation: CAZ51272.1.
RefSeqiYP_003024533.1. NC_012924.1.

Genome annotation databases

EnsemblBacteriaiCAZ51272; CAZ51272; SSUSC84_0494.
GeneIDi8150182.
KEGGisss:SSUSC84_0494.
PATRICi19789922. VBIStrSui134201_0494.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM252031 Genomic DNA. Translation: CAZ51272.1 .
RefSeqi YP_003024533.1. NC_012924.1.

3D structure databases

ProteinModelPortali C6GRB1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 568813.SSUSC84_0494.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAZ51272 ; CAZ51272 ; SSUSC84_0494 .
GeneIDi 8150182.
KEGGi sss:SSUSC84_0494.
PATRICi 19789922. VBIStrSui134201_0494.

Phylogenomic databases

eggNOGi COG0014.
HOGENOMi HOG000246356.
KOi K00147.
OMAi ALTSYKW.
OrthoDBi EOG6FFSCX.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00360 .
BioCyci SSUI568813:GJFC-555-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPi MF_00412. ProA.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000151. GPR. 1 hit.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00407. proA. 1 hit.
PROSITEi PS01223. PROA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC84Imported.

Entry informationi

Entry nameiC6GRB1_STRSX
AccessioniPrimary (citable) accession number: C6GRB1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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