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Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Streptococcus suis (strain SC84)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotationSAAS annotation

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotationSAAS annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-5-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: InterPro

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

NADPUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSSUI568813:GJFC-555-MONOMER.
UniPathwayiUPA00098; UER00360.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductaseUniRule annotationSAAS annotation (EC:1.2.1.41UniRule annotationSAAS annotation)
Short name:
GPRUniRule annotation
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
Gene namesi
Name:proAUniRule annotationImported
Ordered Locus Names:SSUSC84_0494Imported
OrganismiStreptococcus suis (strain SC84)Imported
Taxonomic identifieri568813 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002738: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi568813.SSUSC84_0494.

Structurei

3D structure databases

ProteinModelPortaliC6GRB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0014.
HOGENOMiHOG000246356.
KOiK00147.
OMAiCNAIETL.
OrthoDBiEOG6FFSCX.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPiMF_00412. ProA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF000151. GPR. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00407. proA. 1 hit.
PROSITEiPS01223. PROA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6GRB1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTTQVLLDS LLANKASINL ATTEQKNQAL SAMADQLVAQ TEAILAGNAI
60 70 80 90 100
DMEHAQGKIS QVMQDRLLLT EERIEAMADG IRALIGLPDP VGLVLEESTR
110 120 130 140 150
ADGLNICKKS IPFGLVGMIY ESRPNVTSDA AALAIKSGNA VILRGGKEAF
160 170 180 190 200
HSAKAIVTAL KSGLEEAGVS PKVIELVQDT SRVSATELMT AKGKIDLLVP
210 220 230 240 250
RGGAGLIQAV VENATVPVIE TGTGICHVYV DKDADLDKAL RIVVNAKTSR
260 270 280 290 300
PSVCNAAEVL LVHEEIASQF LPRLEEALSG QVELRADSQA QALLNQARPA
310 320 330 340 350
GDQDFDTEFL DYIMAVKVVS SVEEAISHIA QHSTGHSEAI VTENSQTAEH
360 370 380 390 400
FTLHVDSAAV YVNASTRFTD GGEFGLGCEL GISTQKMHAR GPMGLREMTT
410
YKYIITGDGH IR
Length:412
Mass (Da):43,863
Last modified:September 1, 2009 - v1
Checksum:iC688B33D7A3CFB64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM252031 Genomic DNA. Translation: CAZ51272.1.
RefSeqiYP_003024533.1. NC_012924.1.

Genome annotation databases

EnsemblBacteriaiCAZ51272; CAZ51272; SSUSC84_0494.
GeneIDi8150182.
KEGGisss:SSUSC84_0494.
PATRICi19789922. VBIStrSui134201_0494.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM252031 Genomic DNA. Translation: CAZ51272.1.
RefSeqiYP_003024533.1. NC_012924.1.

3D structure databases

ProteinModelPortaliC6GRB1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi568813.SSUSC84_0494.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAZ51272; CAZ51272; SSUSC84_0494.
GeneIDi8150182.
KEGGisss:SSUSC84_0494.
PATRICi19789922. VBIStrSui134201_0494.

Phylogenomic databases

eggNOGiCOG0014.
HOGENOMiHOG000246356.
KOiK00147.
OMAiCNAIETL.
OrthoDBiEOG6FFSCX.

Enzyme and pathway databases

UniPathwayiUPA00098; UER00360.
BioCyciSSUI568813:GJFC-555-MONOMER.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPiMF_00412. ProA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF000151. GPR. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00407. proA. 1 hit.
PROSITEiPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC84Imported.

Entry informationi

Entry nameiC6GRB1_STRSX
AccessioniPrimary (citable) accession number: C6GRB1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: February 4, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.