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C6GRB1

- C6GRB1_STRSX

UniProt

C6GRB1 - C6GRB1_STRSX

Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Streptococcus suis (strain SC84)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotation
    Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.SAAS annotation

    Catalytic activityi

    L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotationSAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-5-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    NADPUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSSUI568813:GJFC-555-MONOMER.
    UniPathwayiUPA00098; UER00360.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
    Short name:
    GPRUniRule annotation
    Alternative name(s):
    Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
    Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
    Gene namesi
    Name:proAUniRule annotationImported
    Ordered Locus Names:SSUSC84_0494Imported
    OrganismiStreptococcus suis (strain SC84)Imported
    Taxonomic identifieri568813 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002738: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi568813.SSUSC84_0494.

    Structurei

    3D structure databases

    ProteinModelPortaliC6GRB1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0014.
    HOGENOMiHOG000246356.
    KOiK00147.
    OMAiALTSYKW.
    OrthoDBiEOG6FFSCX.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 2 hits.
    HAMAPiMF_00412. ProA.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR000965. G-glutamylP_reductase.
    IPR020593. G-glutamylP_reductase_CS.
    IPR012134. Glu-5-SA_DH.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000151. GPR. 1 hit.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00407. proA. 1 hit.
    PROSITEiPS01223. PROA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C6GRB1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTTQVLLDS LLANKASINL ATTEQKNQAL SAMADQLVAQ TEAILAGNAI    50
    DMEHAQGKIS QVMQDRLLLT EERIEAMADG IRALIGLPDP VGLVLEESTR 100
    ADGLNICKKS IPFGLVGMIY ESRPNVTSDA AALAIKSGNA VILRGGKEAF 150
    HSAKAIVTAL KSGLEEAGVS PKVIELVQDT SRVSATELMT AKGKIDLLVP 200
    RGGAGLIQAV VENATVPVIE TGTGICHVYV DKDADLDKAL RIVVNAKTSR 250
    PSVCNAAEVL LVHEEIASQF LPRLEEALSG QVELRADSQA QALLNQARPA 300
    GDQDFDTEFL DYIMAVKVVS SVEEAISHIA QHSTGHSEAI VTENSQTAEH 350
    FTLHVDSAAV YVNASTRFTD GGEFGLGCEL GISTQKMHAR GPMGLREMTT 400
    YKYIITGDGH IR 412
    Length:412
    Mass (Da):43,863
    Last modified:September 1, 2009 - v1
    Checksum:iC688B33D7A3CFB64
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM252031 Genomic DNA. Translation: CAZ51272.1.
    RefSeqiYP_003024533.1. NC_012924.1.

    Genome annotation databases

    EnsemblBacteriaiCAZ51272; CAZ51272; SSUSC84_0494.
    GeneIDi8150182.
    KEGGisss:SSUSC84_0494.
    PATRICi19789922. VBIStrSui134201_0494.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM252031 Genomic DNA. Translation: CAZ51272.1 .
    RefSeqi YP_003024533.1. NC_012924.1.

    3D structure databases

    ProteinModelPortali C6GRB1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 568813.SSUSC84_0494.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAZ51272 ; CAZ51272 ; SSUSC84_0494 .
    GeneIDi 8150182.
    KEGGi sss:SSUSC84_0494.
    PATRICi 19789922. VBIStrSui134201_0494.

    Phylogenomic databases

    eggNOGi COG0014.
    HOGENOMi HOG000246356.
    KOi K00147.
    OMAi ALTSYKW.
    OrthoDBi EOG6FFSCX.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00360 .
    BioCyci SSUI568813:GJFC-555-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 2 hits.
    HAMAPi MF_00412. ProA.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR000965. G-glutamylP_reductase.
    IPR020593. G-glutamylP_reductase_CS.
    IPR012134. Glu-5-SA_DH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000151. GPR. 1 hit.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00407. proA. 1 hit.
    PROSITEi PS01223. PROA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC84Imported.

    Entry informationi

    Entry nameiC6GRB1_STRSX
    AccessioniPrimary (citable) accession number: C6GRB1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 1, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3