ID   C6G7W3_HUMAN            Unreviewed;       121 AA.
AC   C6G7W3;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   24-JAN-2024, entry version 55.
DE   RecName: Full=P2Y purinoceptor 4 {ECO:0000256|ARBA:ARBA00021864};
DE   Flags: Fragment;
GN   Name=P2RY4 {ECO:0000313|EMBL:ACS66695.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ACS66695.1};
RN   [1] {ECO:0000313|EMBL:ACS66695.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Scodelaro Bilbao P.G., Boland R.L., Santillan G.E.;
RT   "Role of PKC and Src in the activation of MAP kinases by ATP in MCF-7
RT   cells.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACS66695.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=19900397; DOI=10.1016/j.abb.2009.11.002;
RA   Scodelaro Bilbao P., Boland R., Santillan G.;
RT   "ATP modulates transcription factors through P2Y2 and P2Y4 receptors via
RT   PKC/MAPKs and PKC/Src pathways in MCF-7 cells.";
RL   Arch. Biochem. Biophys. 494:7-14(2010).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; FJ599701; ACS66695.1; -; mRNA.
DR   AlphaFoldDB; C6G7W3; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045028; F:G protein-coupled purinergic nucleotide receptor activity; IEA:InterPro.
DR   GO; GO:0030321; P:transepithelial chloride transport; IEA:InterPro.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000018; P2Y4.
DR   PANTHER; PTHR24231:SF21; P2Y PURINOCEPTOR 4; 1.
DR   PANTHER; PTHR24231; PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR01066; P2Y4PRNOCPTR.
DR   PRINTS; PR01157; P2YPURNOCPTR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:ACS66695.1};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        29..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        67..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..121
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACS66695.1"
FT   NON_TER         121
FT                   /evidence="ECO:0000313|EMBL:ACS66695.1"
SQ   SEQUENCE   121 AA;  14001 MW;  C68E644A8759C0A5 CRC64;
     VLSLPTLIYY YAAHNHWPFG TEICKFVRFL FYWNLYCSVL FLTCISVHRY LGICHPLRAL
     RWGRPRLAGL LCLAVWLVVA GCLVPNLFFV TTSNKGTTVL CHDTTRPEEF DHYVHFSSAV
     M
//