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C6G7W3

- C6G7W3_HUMAN

UniProt

C6G7W3 - C6G7W3_HUMAN

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Protein
Submitted name:

Pyrimidinergic receptor P2Y4

Gene
P2RY4
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: Ensembl
  2. G-protein coupled purinergic nucleotide receptor activity Source: InterPro
  3. UTP-activated nucleotide receptor activity Source: Ensembl

GO - Biological processi

  1. transepithelial chloride transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Pyrimidinergic receptor P2Y4Imported
Gene namesi
Name:P2RY4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basolateral plasma membrane Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ArrayExpressiC6G7W3.
BgeeiC6G7W3.

Interactioni

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

TransmembraneUniRule annotation

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000018. P2Y4_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF21. PTHR24231:SF21. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01066. P2Y4PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

C6G7W3-1 [UniParc]FASTAAdd to Basket

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VLSLPTLIYY YAAHNHWPFG TEICKFVRFL FYWNLYCSVL FLTCISVHRY    50
LGICHPLRAL RWGRPRLAGL LCLAVWLVVA GCLVPNLFFV TTSNKGTTVL 100
CHDTTRPEEF DHYVHFSSAV M 121
Length:121
Mass (Da):14,001
Last modified:September 1, 2009 - v1
Checksum:iC68E644A8759C0A5
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei121 – 1211Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ599701 mRNA. Translation: ACS66695.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ599701 mRNA. Translation: ACS66695.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi C6G7W3.

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

NextBioi 35483014.

Gene expression databases

ArrayExpressi C6G7W3.
Bgeei C6G7W3.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000018. P2Y4_rcpt.
[Graphical view ]
PANTHERi PTHR24231:SF21. PTHR24231:SF21. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01066. P2Y4PRNOCPTR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Role of PKC and Src in the activation of MAP kinases by ATP in MCF-7 cells."
    Scodelaro Bilbao P.G., Boland R.L., Santillan G.E.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "ATP modulates transcription factors through P2Y2 and P2Y4 receptors via PKC/MAPKs and PKC/Src pathways in MCF-7 cells."
    Scodelaro Bilbao P., Boland R., Santillan G.
    Arch. Biochem. Biophys. 494:7-14(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiC6G7W3_HUMAN
AccessioniPrimary (citable) accession number: C6G7W3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: April 16, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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