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C6G7W3

- C6G7W3_HUMAN

UniProt

C6G7W3 - C6G7W3_HUMAN

Protein
Submitted name:

Pyrimidinergic receptor P2Y4

Gene

P2RY4

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. ATP binding Source: Ensembl
    2. G-protein coupled purinergic nucleotide receptor activity Source: InterPro
    3. UTP-activated nucleotide receptor activity Source: Ensembl

    GO - Biological processi

    1. transepithelial chloride transport Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptorUniRule annotation, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Pyrimidinergic receptor P2Y4Imported
    Gene namesi
    Name:P2RY4Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basolateral plasma membrane Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    ArrayExpressiC6G7W3.
    BgeeiC6G7W3.

    Interactioni

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000018. P2Y4_rcpt.
    [Graphical view]
    PANTHERiPTHR24231:SF21. PTHR24231:SF21. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01066. P2Y4PRNOCPTR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    C6G7W3-1 [UniParc]FASTAAdd to Basket

    « Hide

    VLSLPTLIYY YAAHNHWPFG TEICKFVRFL FYWNLYCSVL FLTCISVHRY    50
    LGICHPLRAL RWGRPRLAGL LCLAVWLVVA GCLVPNLFFV TTSNKGTTVL 100
    CHDTTRPEEF DHYVHFSSAV M 121
    Length:121
    Mass (Da):14,001
    Last modified:September 1, 2009 - v1
    Checksum:iC68E644A8759C0A5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei121 – 1211Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ599701 mRNA. Translation: ACS66695.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ599701 mRNA. Translation: ACS66695.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi C6G7W3.

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    NextBioi 35483014.

    Gene expression databases

    ArrayExpressi C6G7W3.
    Bgeei C6G7W3.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000018. P2Y4_rcpt.
    [Graphical view ]
    PANTHERi PTHR24231:SF21. PTHR24231:SF21. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01066. P2Y4PRNOCPTR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Role of PKC and Src in the activation of MAP kinases by ATP in MCF-7 cells."
      Scodelaro Bilbao P.G., Boland R.L., Santillan G.E.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "ATP modulates transcription factors through P2Y2 and P2Y4 receptors via PKC/MAPKs and PKC/Src pathways in MCF-7 cells."
      Scodelaro Bilbao P., Boland R., Santillan G.
      Arch. Biochem. Biophys. 494:7-14(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiC6G7W3_HUMAN
    AccessioniPrimary (citable) accession number: C6G7W3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 1, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.