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C6G099

- C6G099_9HIV1

UniProt

C6G099 - C6G099_9HIV1

Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.UniRule annotationSAAS annotation
    The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.SAAS annotation

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. evasion or tolerance by virus of host immune response Source: UniProtKB-KW
    3. membrane fusion involved in viral entry into host cell Source: UniProtKB-KW
    4. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    ApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral immunoevasionUniRule annotation, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein gp160UniRule annotation
    Gene namesi
    Name:envImported
    OrganismiHuman immunodeficiency virus 1Imported
    Taxonomic identifieri11676 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

    GO - Cellular componenti

    1. host cell endosome membrane Source: UniProtKB-SubCell
    2. host cell plasma membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. viral envelope Source: UniProtKB-KW
    5. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membraneSAAS annotation, Host endosomeSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotationImported, Virion

    Pathology & Biotechi

    Keywords - Diseasei

    AIDSUniRule annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi184 – 1841N-linked (GlcNAc...)Imported
    Glycosylationi291 – 2911N-linked (GlcNAc...)Imported

    Keywords - PTMi

    Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3TGRX-ray2.80A/B39-478[»]
    3TGSX-ray2.70A/B39-478[»]
    4I53X-ray2.50A/B39-478[»]
    4LSVX-ray3.00G39-478[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Family and domain databases

    Gene3Di2.170.40.20. 2 hits.
    InterProiIPR000777. HIV1_GP160.
    IPR000328. Retroviral_envelope_protein.
    [Graphical view]
    PfamiPF00516. GP120. 1 hit.
    PF00517. GP41. 1 hit.
    [Graphical view]
    SUPFAMiSSF56502. SSF56502. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    C6G099-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVRGIWKNW PQWLIWSILG FWIGNMEGSW VTVYYGVPVW KEAKTTLFCA    50
    SDAKAYEKEV HNVWATHACV PTDPNPQEMV LANVTENFNM WKNDMVEQMH 100
    EDIISLWDES LKPCVKLTPL CVTLNCTNVK GNESDTSEVM KNCSFKATTE 150
    LKDKKHKVHA LFYKLDVVPL NGNSSSSGEY RLINCNTSAI TQACPKVSFD 200
    PIPLHYCAPA GFAILKCNNK TFNGTGPCRN VSTVQCTHGI KPVVSTQLLL 250
    NGSLAEEEII IRSENLTNNA KTIIVHLNES VNIVCTRPNN NTRKSIRIGP 300
    GQTFYATGDI IGNIRQAHCN INESKWNNTL QKVGEELAKH FPSKTIKFEP 350
    SSGGDLEITT HSFNCRGEFF YCNTSDLFNG TYRNGTYNHT GRSSNGTITL 400
    QCKIKQIINM WQEVGRAIYA PPIEGEITCN SNITGLLLLR DGGQSNETND 450
    TETFRPGGGD MRDNWRSELY KYKVVEIKPL GVAPTEAKRR VVEREKRAVG 500
    IGAVFLGFLG AAGSTMGAAS MTLTVQARQL LSGIVQQQSN LLRAIEAQQH 550
    MLQLTVWGIK QLQARVLAIE RYLKDQQLLG MWGCSGKLIC TTAVPWNSSW 600
    SNKSQNEIWG NMTWMQWDRE INNYTNTIYR LLEDSQNQQE KNEKDLLALD 650
    SWKNLWNWFD ISKWLWYIKI FIMIIGGLIG LRIIFAVLSI VKRVRQGYSP 700
    LSFQTLTPNP RGPDRPGGIE EEGGEQDRDR SARLASGFLT LVWDDLRSLC 750
    LFSYHLLRDF ILVATRTVEL LGRSSLKGLQ RGWEILRYLG SLVQYWGLEL 800
    KKSAISLIDT IAIAVAERTD RIIEIVQRIC RAIRNIPRRI RQGFETALL 849
    Length:849
    Mass (Da):96,054
    Last modified:September 1, 2009 - v1
    Checksum:iAE4C240E240E501F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ444394 Genomic DNA. Translation: ACS67968.1.
    FJ444395 Genomic DNA. Translation: ACS67969.1.
    FJ444396 Genomic DNA. Translation: ACS67970.1.
    FJ444399 Genomic DNA. Translation: ACS67972.1.
    FJ444404 Genomic DNA. Translation: ACS67973.1.
    FJ444407 Genomic DNA. Translation: ACS67976.1.
    FJ444409 Genomic DNA. Translation: ACS67978.1.
    FJ444410 Genomic DNA. Translation: ACS67979.1.
    FJ444411 Genomic DNA. Translation: ACS67980.1.
    FJ444414 Genomic DNA. Translation: ACS67982.1.
    FJ444415 Genomic DNA. Translation: ACS67983.1.
    KC894079 Genomic RNA. Translation: AGV38303.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ444394 Genomic DNA. Translation: ACS67968.1 .
    FJ444395 Genomic DNA. Translation: ACS67969.1 .
    FJ444396 Genomic DNA. Translation: ACS67970.1 .
    FJ444399 Genomic DNA. Translation: ACS67972.1 .
    FJ444404 Genomic DNA. Translation: ACS67973.1 .
    FJ444407 Genomic DNA. Translation: ACS67976.1 .
    FJ444409 Genomic DNA. Translation: ACS67978.1 .
    FJ444410 Genomic DNA. Translation: ACS67979.1 .
    FJ444411 Genomic DNA. Translation: ACS67980.1 .
    FJ444414 Genomic DNA. Translation: ACS67982.1 .
    FJ444415 Genomic DNA. Translation: ACS67983.1 .
    KC894079 Genomic RNA. Translation: AGV38303.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3TGR X-ray 2.80 A/B 39-478 [» ]
    3TGS X-ray 2.70 A/B 39-478 [» ]
    4I53 X-ray 2.50 A/B 39-478 [» ]
    4LSV X-ray 3.00 G 39-478 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.170.40.20. 2 hits.
    InterProi IPR000777. HIV1_GP160.
    IPR000328. Retroviral_envelope_protein.
    [Graphical view ]
    Pfami PF00516. GP120. 1 hit.
    PF00517. GP41. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56502. SSF56502. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Hraber P.T.
      Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 1086-B12Imported, 1086-B2Imported, 1086-B5Imported, 1086-C2Imported, 1086-E12Imported, 1086-F8Imported, 1086-G1Imported, 1086-G12Imported, 1086-G2Imported, 1086-H1Imported and 1086-H9Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 1086-B12Imported, 1086-B2Imported, 1086-B5Imported, 1086-C2Imported, 1086-E12Imported, 1086-F8Imported, 1086-G1Imported, 1086-G12Imported, 1086-G2Imported, 1086-H1Imported and 1086-H9Imported.
    3. "Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops."
      Kwon Y.D., Finzi A., Wu X., Dogo-Isonagie C., Lee L.K., Moore L.R., Schmidt S.D., Stuckey J., Yang Y., Zhou T., Zhu J., Vicic D.A., Debnath A.K., Shapiro L., Bewley C.A., Mascola J.R., Sodroski J.G., Kwong P.D.
      Proc. Natl. Acad. Sci. U.S.A. 109:5663-5668(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 39-478, GLYCOSYLATION AT ASN-184 AND ASN-291.
    4. "Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization."
      Lalonde J.M., Le-Khac M., Jones D.M., Courter J.R., Park J., Schon A., Princiotto A.M., Wu X., Mascola J.R., Freire E., Sodroski J., Madani N., Hendrickson W.A., Smith A.B.
      ACS Med. Chem. Lett. 4:338-343(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 39-478, GLYCOSYLATION AT ASN-184 AND ASN-291.
    5. Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 39-478, GLYCOSYLATION AT ASN-184 AND ASN-291.
    6. "Comparison of viral Env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design."
      Ping L.H., Joseph S.B., Anderson J.A., Abrahams M.R., Salazar-Gonzalez J.F., Kincer L.P., Treurnicht F.K., Arney L., Ojeda S., Zhang M., Keys J., Potter E.L., Chu H., Moore P., Salazar M.G., Iyer S., Jabara C., Kirchherr J.
      , Mapanje C., Ngandu N., Seoighe C., Hoffman I., Gao F., Tang Y., Labranche C., Lee B., Saville A., Vermeulen M., Fiscus S., Morris L., Karim S.A., Haynes B.F., Shaw G.M., Korber B.T., Hahn B.H., Cohen M.S., Montefiori D., Williamson C., Swanstrom R.
      J. Virol. 87:7218-7233(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 1086-B2Imported.
    7. Ping L.-H.
      Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 1086-B2Imported.

    Entry informationi

    Entry nameiC6G099_9HIV1
    AccessioniPrimary (citable) accession number: C6G099
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 1, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3