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C6G099

- C6G099_9HIV1

UniProt

C6G099 - C6G099_9HIV1

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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.UniRule annotationSAAS annotation
The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.SAAS annotation

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. evasion or tolerance by virus of host immune response Source: UniProtKB-KW
  3. membrane fusion involved in viral entry into host cell Source: UniProtKB-KW
  4. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral immunoevasionUniRule annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160UniRule annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

GO - Cellular componenti

  1. host cell endosome membrane Source: UniProtKB-SubCell
  2. host cell plasma membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. viral envelope Source: UniProtKB-KW
  5. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotation, Host endosomeSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotation, Virion

Pathology & Biotechi

Keywords - Diseasei

AIDSUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi184 – 1841N-linked (GlcNAc...)Imported
Glycosylationi291 – 2911N-linked (GlcNAc...)Imported

Keywords - PTMi

Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TGRX-ray2.80A/B39-478[»]
3TGSX-ray2.70A/B39-478[»]
4I53X-ray2.50A/B39-478[»]
4LSVX-ray3.00G39-478[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

Gene3Di2.170.40.20. 2 hits.
InterProiIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamiPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.

Sequencei

Sequence statusi: Complete.

C6G099-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVRGIWKNW PQWLIWSILG FWIGNMEGSW VTVYYGVPVW KEAKTTLFCA
60 70 80 90 100
SDAKAYEKEV HNVWATHACV PTDPNPQEMV LANVTENFNM WKNDMVEQMH
110 120 130 140 150
EDIISLWDES LKPCVKLTPL CVTLNCTNVK GNESDTSEVM KNCSFKATTE
160 170 180 190 200
LKDKKHKVHA LFYKLDVVPL NGNSSSSGEY RLINCNTSAI TQACPKVSFD
210 220 230 240 250
PIPLHYCAPA GFAILKCNNK TFNGTGPCRN VSTVQCTHGI KPVVSTQLLL
260 270 280 290 300
NGSLAEEEII IRSENLTNNA KTIIVHLNES VNIVCTRPNN NTRKSIRIGP
310 320 330 340 350
GQTFYATGDI IGNIRQAHCN INESKWNNTL QKVGEELAKH FPSKTIKFEP
360 370 380 390 400
SSGGDLEITT HSFNCRGEFF YCNTSDLFNG TYRNGTYNHT GRSSNGTITL
410 420 430 440 450
QCKIKQIINM WQEVGRAIYA PPIEGEITCN SNITGLLLLR DGGQSNETND
460 470 480 490 500
TETFRPGGGD MRDNWRSELY KYKVVEIKPL GVAPTEAKRR VVEREKRAVG
510 520 530 540 550
IGAVFLGFLG AAGSTMGAAS MTLTVQARQL LSGIVQQQSN LLRAIEAQQH
560 570 580 590 600
MLQLTVWGIK QLQARVLAIE RYLKDQQLLG MWGCSGKLIC TTAVPWNSSW
610 620 630 640 650
SNKSQNEIWG NMTWMQWDRE INNYTNTIYR LLEDSQNQQE KNEKDLLALD
660 670 680 690 700
SWKNLWNWFD ISKWLWYIKI FIMIIGGLIG LRIIFAVLSI VKRVRQGYSP
710 720 730 740 750
LSFQTLTPNP RGPDRPGGIE EEGGEQDRDR SARLASGFLT LVWDDLRSLC
760 770 780 790 800
LFSYHLLRDF ILVATRTVEL LGRSSLKGLQ RGWEILRYLG SLVQYWGLEL
810 820 830 840
KKSAISLIDT IAIAVAERTD RIIEIVQRIC RAIRNIPRRI RQGFETALL
Length:849
Mass (Da):96,054
Last modified:September 1, 2009 - v1
Checksum:iAE4C240E240E501F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ444394 Genomic DNA. Translation: ACS67968.1.
FJ444395 Genomic DNA. Translation: ACS67969.1.
FJ444396 Genomic DNA. Translation: ACS67970.1.
FJ444399 Genomic DNA. Translation: ACS67972.1.
FJ444404 Genomic DNA. Translation: ACS67973.1.
FJ444407 Genomic DNA. Translation: ACS67976.1.
FJ444409 Genomic DNA. Translation: ACS67978.1.
FJ444410 Genomic DNA. Translation: ACS67979.1.
FJ444411 Genomic DNA. Translation: ACS67980.1.
FJ444414 Genomic DNA. Translation: ACS67982.1.
FJ444415 Genomic DNA. Translation: ACS67983.1.
KC894079 Genomic RNA. Translation: AGV38303.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ444394 Genomic DNA. Translation: ACS67968.1 .
FJ444395 Genomic DNA. Translation: ACS67969.1 .
FJ444396 Genomic DNA. Translation: ACS67970.1 .
FJ444399 Genomic DNA. Translation: ACS67972.1 .
FJ444404 Genomic DNA. Translation: ACS67973.1 .
FJ444407 Genomic DNA. Translation: ACS67976.1 .
FJ444409 Genomic DNA. Translation: ACS67978.1 .
FJ444410 Genomic DNA. Translation: ACS67979.1 .
FJ444411 Genomic DNA. Translation: ACS67980.1 .
FJ444414 Genomic DNA. Translation: ACS67982.1 .
FJ444415 Genomic DNA. Translation: ACS67983.1 .
KC894079 Genomic RNA. Translation: AGV38303.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3TGR X-ray 2.80 A/B 39-478 [» ]
3TGS X-ray 2.70 A/B 39-478 [» ]
4I53 X-ray 2.50 A/B 39-478 [» ]
4LSV X-ray 3.00 G 39-478 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.170.40.20. 2 hits.
InterProi IPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view ]
Pfami PF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view ]
SUPFAMi SSF56502. SSF56502. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Hraber P.T.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 1086-B12Imported, 1086-B2Imported, 1086-B5Imported, 1086-C2Imported, 1086-E12Imported, 1086-F8Imported, 1086-G1Imported, 1086-G12Imported, 1086-G2Imported, 1086-H1Imported and 1086-H9Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 1086-B12Imported, 1086-B2Imported, 1086-B5Imported, 1086-C2Imported, 1086-E12Imported, 1086-F8Imported, 1086-G1Imported, 1086-G12Imported, 1086-G2Imported, 1086-H1Imported and 1086-H9Imported.
  3. "Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops."
    Kwon Y.D., Finzi A., Wu X., Dogo-Isonagie C., Lee L.K., Moore L.R., Schmidt S.D., Stuckey J., Yang Y., Zhou T., Zhu J., Vicic D.A., Debnath A.K., Shapiro L., Bewley C.A., Mascola J.R., Sodroski J.G., Kwong P.D.
    Proc. Natl. Acad. Sci. U.S.A. 109:5663-5668(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 39-478, GLYCOSYLATION AT ASN-184 AND ASN-291.
  4. "Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization."
    Lalonde J.M., Le-Khac M., Jones D.M., Courter J.R., Park J., Schon A., Princiotto A.M., Wu X., Mascola J.R., Freire E., Sodroski J., Madani N., Hendrickson W.A., Smith A.B.
    ACS Med. Chem. Lett. 4:338-343(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 39-478, GLYCOSYLATION AT ASN-184 AND ASN-291.
  5. Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 39-478, GLYCOSYLATION AT ASN-184 AND ASN-291.
  6. "Comparison of viral Env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design."
    Ping L.H., Joseph S.B., Anderson J.A., Abrahams M.R., Salazar-Gonzalez J.F., Kincer L.P., Treurnicht F.K., Arney L., Ojeda S., Zhang M., Keys J., Potter E.L., Chu H., Moore P., Salazar M.G., Iyer S., Jabara C., Kirchherr J.
    , Mapanje C., Ngandu N., Seoighe C., Hoffman I., Gao F., Tang Y., Labranche C., Lee B., Saville A., Vermeulen M., Fiscus S., Morris L., Karim S.A., Haynes B.F., Shaw G.M., Korber B.T., Hahn B.H., Cohen M.S., Montefiori D., Williamson C., Swanstrom R.
    J. Virol. 87:7218-7233(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 1086-B2Imported.
  7. Ping L.-H.
    Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 1086-B2Imported.

Entry informationi

Entry nameiC6G099_9HIV1
AccessioniPrimary (citable) accession number: C6G099
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3