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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ApoptosisUniRule annotationSAAS annotation, Fusion of virus membrane with host membraneUniRule annotationSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160UniRule annotation
Cleaved into the following 2 chains:
Surface protein gp120UniRule annotation
Short name:
SUUniRule annotation
Alternative name(s):
Glycoprotein 120UniRule annotation
Short name:
gp120UniRule annotation
Transmembrane protein gp41UniRule annotation
Short name:
TMUniRule annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 37HelicalUniRule annotationAdd BLAST25
Transmembranei498 – 521HelicalUniRule annotationAdd BLAST24
Transmembranei664 – 691HelicalUniRule annotationAdd BLAST28

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneUniRule annotationSAAS annotation, Host endosomeUniRule annotationSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotationImported, Virion

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 69Combined sources
Disulfide bondi114 ↔ 194Combined sources
GlycosylationiCAR_5007361010184N-linked (GlcNAc...)Combined sources1
Disulfide bondi207 ↔ 236Combined sources
Disulfide bondi217 ↔ 228Combined sources
Disulfide bondi285 ↔ 319Combined sources
GlycosylationiCAR_5007361011291N-linked (GlcNAc...)Combined sources1
Disulfide bondi365 ↔ 429Combined sources
Disulfide bondi372 ↔ 402Combined sources

Keywords - PTMi

Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

Interactioni

Subunit structurei

The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. The resulting complex protrudes from the virus surface as a spike.UniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TGRX-ray2.80A/B39-478[»]
3TGSX-ray2.70A/B39-478[»]
4I53X-ray2.50A/B39-478[»]
4LSVX-ray3.00G39-478[»]
5F4LX-ray2.70A/B44-477[»]
5F4PX-ray2.60A/D44-477[»]
5F4RX-ray2.80A/C44-477[»]
5F4UX-ray3.10A/B44-477[»]
SMRiC6G099.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 134GP120InterPro annotationAdd BLAST105
Domaini138 – 497GP120InterPro annotationAdd BLAST360
Domaini516 – 706GP41InterPro annotationAdd BLAST191

Domaini

The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

CDDicd09909. HIV-1-like_HR1-HR2. 1 hit.
Gene3Di2.170.40.20. 2 hits.
InterProiIPR000328. GP41-like.
IPR000777. HIV1_GP160.
[Graphical view]
PfamiPF00516. GP120. 2 hits.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C6G099-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVRGIWKNW PQWLIWSILG FWIGNMEGSW VTVYYGVPVW KEAKTTLFCA
60 70 80 90 100
SDAKAYEKEV HNVWATHACV PTDPNPQEMV LANVTENFNM WKNDMVEQMH
110 120 130 140 150
EDIISLWDES LKPCVKLTPL CVTLNCTNVK GNESDTSEVM KNCSFKATTE
160 170 180 190 200
LKDKKHKVHA LFYKLDVVPL NGNSSSSGEY RLINCNTSAI TQACPKVSFD
210 220 230 240 250
PIPLHYCAPA GFAILKCNNK TFNGTGPCRN VSTVQCTHGI KPVVSTQLLL
260 270 280 290 300
NGSLAEEEII IRSENLTNNA KTIIVHLNES VNIVCTRPNN NTRKSIRIGP
310 320 330 340 350
GQTFYATGDI IGNIRQAHCN INESKWNNTL QKVGEELAKH FPSKTIKFEP
360 370 380 390 400
SSGGDLEITT HSFNCRGEFF YCNTSDLFNG TYRNGTYNHT GRSSNGTITL
410 420 430 440 450
QCKIKQIINM WQEVGRAIYA PPIEGEITCN SNITGLLLLR DGGQSNETND
460 470 480 490 500
TETFRPGGGD MRDNWRSELY KYKVVEIKPL GVAPTEAKRR VVEREKRAVG
510 520 530 540 550
IGAVFLGFLG AAGSTMGAAS MTLTVQARQL LSGIVQQQSN LLRAIEAQQH
560 570 580 590 600
MLQLTVWGIK QLQARVLAIE RYLKDQQLLG MWGCSGKLIC TTAVPWNSSW
610 620 630 640 650
SNKSQNEIWG NMTWMQWDRE INNYTNTIYR LLEDSQNQQE KNEKDLLALD
660 670 680 690 700
SWKNLWNWFD ISKWLWYIKI FIMIIGGLIG LRIIFAVLSI VKRVRQGYSP
710 720 730 740 750
LSFQTLTPNP RGPDRPGGIE EEGGEQDRDR SARLASGFLT LVWDDLRSLC
760 770 780 790 800
LFSYHLLRDF ILVATRTVEL LGRSSLKGLQ RGWEILRYLG SLVQYWGLEL
810 820 830 840
KKSAISLIDT IAIAVAERTD RIIEIVQRIC RAIRNIPRRI RQGFETALL
Length:849
Mass (Da):96,054
Last modified:September 1, 2009 - v1
Checksum:iAE4C240E240E501F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ444394 Genomic DNA. Translation: ACS67968.1.
FJ444395 Genomic DNA. Translation: ACS67969.1.
FJ444396 Genomic DNA. Translation: ACS67970.1.
FJ444399 Genomic DNA. Translation: ACS67972.1.
FJ444404 Genomic DNA. Translation: ACS67973.1.
FJ444407 Genomic DNA. Translation: ACS67976.1.
FJ444409 Genomic DNA. Translation: ACS67978.1.
FJ444410 Genomic DNA. Translation: ACS67979.1.
FJ444411 Genomic DNA. Translation: ACS67980.1.
FJ444414 Genomic DNA. Translation: ACS67982.1.
FJ444415 Genomic DNA. Translation: ACS67983.1.
KC894079 Genomic RNA. Translation: AGV38303.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ444394 Genomic DNA. Translation: ACS67968.1.
FJ444395 Genomic DNA. Translation: ACS67969.1.
FJ444396 Genomic DNA. Translation: ACS67970.1.
FJ444399 Genomic DNA. Translation: ACS67972.1.
FJ444404 Genomic DNA. Translation: ACS67973.1.
FJ444407 Genomic DNA. Translation: ACS67976.1.
FJ444409 Genomic DNA. Translation: ACS67978.1.
FJ444410 Genomic DNA. Translation: ACS67979.1.
FJ444411 Genomic DNA. Translation: ACS67980.1.
FJ444414 Genomic DNA. Translation: ACS67982.1.
FJ444415 Genomic DNA. Translation: ACS67983.1.
KC894079 Genomic RNA. Translation: AGV38303.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TGRX-ray2.80A/B39-478[»]
3TGSX-ray2.70A/B39-478[»]
4I53X-ray2.50A/B39-478[»]
4LSVX-ray3.00G39-478[»]
5F4LX-ray2.70A/B44-477[»]
5F4PX-ray2.60A/D44-477[»]
5F4RX-ray2.80A/C44-477[»]
5F4UX-ray3.10A/B44-477[»]
SMRiC6G099.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd09909. HIV-1-like_HR1-HR2. 1 hit.
Gene3Di2.170.40.20. 2 hits.
InterProiIPR000328. GP41-like.
IPR000777. HIV1_GP160.
[Graphical view]
PfamiPF00516. GP120. 2 hits.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiC6G099_9HIV1
AccessioniPrimary (citable) accession number: C6G099
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: November 30, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.