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Protein

Natriuretic and helokinestatin peptides

Gene
N/A
Organism
Heloderma suspectum cinctum (Banded Gila monster)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Helokinestatin antagonizes the vasodilatory actions of bradykinin at the B2 bradykinin receptor (BDKRB2), with helokinestatin-1 being the most potent antagonist.1 Publication
Natriuretic peptide exhibits vasoactive properties and induces hypotension, possibly by binding to natriuretic peptide receptor NPR1.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionBradykinin receptor impairing toxin, G-protein coupled receptor impairing toxin, Hypotensive agent, Toxin, Vasoactive

Names & Taxonomyi

Protein namesi
Recommended name:
Natriuretic and helokinestatin peptides1 Publication
Cleaved into the following 5 chains:
Helokinestatin-11 Publication
Short name:
HKS-11 Publication
Helokinestatin-21 Publication
Short name:
HKS-21 Publication
Helokinestatin-31 Publication
Short name:
HKS-31 Publication
Helokinestatin-41 Publication
Short name:
HKS-41 Publication
Natriuretic peptide1 Publication
OrganismiHeloderma suspectum cinctum (Banded Gila monster)
Taxonomic identifieri537493 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaAnguimorphaNeoanguimorphaHelodermatidaeHeloderma

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000039245426 – 581 PublicationAdd BLAST33
PeptideiPRO_000039245559 – 68Helokinestatin-11 Publication10
PropeptideiPRO_000039245669 – 731 Publication5
PeptideiPRO_000039245774 – 84Helokinestatin-21 PublicationAdd BLAST11
PropeptideiPRO_000039245885 – 891 Publication5
PeptideiPRO_000039245990 – 102Helokinestatin-31 PublicationAdd BLAST13
PropeptideiPRO_0000392460103 – 1121 Publication10
PeptideiPRO_0000392461113 – 122Helokinestatin-41 Publication10
PropeptideiPRO_0000392462123 – 1461 PublicationAdd BLAST24
PeptideiPRO_0000392463147 – 178Natriuretic peptide1 PublicationAdd BLAST32

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi153 ↔ 169By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiC6EVG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the C-terminal section; belongs to the natriuretic peptide family.Sequence analysis

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR000663. Natr_peptide.
IPR030480. Natr_peptide_CS.
IPR002408. Natriuretic_peptide_brain.
PfamiView protein in Pfam
PF00212. ANP. 1 hit.
PRINTSiPR00712. BNATPEPTIDE.
SMARTiView protein in SMART
SM00183. NAT_PEP. 1 hit.
PROSITEiView protein in PROSITE
PS00263. NATRIURETIC_PEPTIDE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C6EVG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPRLACSTW LPLLLVLFTL DQGRANPVER GQEYRSLSKR FDDDSTELIL
60 70 80 90 100
EPRASEENGP PYQPLVPRAS DENVPPAYVP LVPRASDENV PPPPLQMPLI
110 120 130 140 150
PRASEQKGPP FNPPPFVDYE PRAANENALR KLIKRSFERS PGRNKRLSPG
160 170
DGCFGQKIDR IGAVSGMGCN SVSSQGKK
Length:178
Mass (Da):19,672
Last modified:September 1, 2009 - v1
Checksum:i2B0F1F9895FBA88F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU790965 mRNA. Translation: ACE95067.1.

Similar proteinsi

Entry informationi

Entry nameiVNHP_HELSC
AccessioniPrimary (citable) accession number: C6EVG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: September 1, 2009
Last modified: November 22, 2017
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families