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C6EHH9 (C6EHH9_ECOBD) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glyoxylate/hydroxypyruvate reductase A HAMAP MF_01666
EC=1.1.1.79 HAMAP MF_01666
EC=1.1.1.81 HAMAP MF_01666
Alternative name(s):
2-ketoacid reductase HAMAP MF_01666
Gene names
Name:ycdW EMBL ACT42925.1
Synonyms:ghrA HAMAP MF_01666 EMBL CAQ31554.1
Ordered Locus Names:B21_01037, ECBD_2566, ECD_01030
OrganismEscherichia coli (strain B / BL21-DE3) [Complete proteome] [HAMAP]
Taxonomic identifier469008 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively By similarity. HAMAP MF_01666

Catalytic activity

D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H. HAMAP MF_01666

Glycolate + NADP+ = glyoxylate + NADPH. HAMAP MF_01666

Subcellular location

Cytoplasm By similarity HAMAP MF_01666.

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily. HAMAP MF_01666

Sequences

Sequence LengthMass (Da)Tools
C6EHH9 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: 5B2F96722CDC6B40

FASTA31235,315
        10         20         30         40         50         60 
MDIIFYHPTF DTQWWIEALR KAIPQARVRA WKSGDNDSAD YALVWHPPVE MLAGRDLKAV 

        70         80         90        100        110        120 
FALGAGVDSI LSKLQAHPEM LNPSVPLFRL EDTGMGEQMQ EYAVSQVLHW FRRFDDYRIQ 

       130        140        150        160        170        180 
QNSSHWQPLP EYHREDFTIG ILGAGVLGSK VAQSLQTWRF PLRCWSRTRK SWPGVQSFAG 

       190        200        210        220        230        240 
REELSAFLSQ CRVLINLLPN TPETVGIINQ QLLEKLPDGA YLLNLARGVH VVEDDLLAAL 

       250        260        270        280        290        300 
DSGKVKGAML DVFNREPLPP ESPLWQHPRV TITPHVAAIT RPAEAVEYIS RTIAQLEKGE 

       310 
KVCGQVDRAR GY

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References

[1]"Genome sequences of Escherichia coli B strains REL606 and BL21(DE3)."
Jeong H., Barbe V., Lee C.H., Vallenet D., Yu D.S., Choi S.H., Couloux A., Lee S.W., Yoon S.H., Cattolico L., Hur C.G., Park H.S., Segurens B., Kim S.C., Oh T.K., Lenski R.E., Studier F.W., Daegelen P., Kim J.F.
J. Mol. Biol. 394:644-652(2009) [PubMed: 19786035] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: B / BL21-DE3 [Korea].
[2]"Sequencing and gene expression analysis of Escherichia coli BL21."
Leparc G., Striedner G., Bayer K., Kreil D., Krempl P.M.
Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: B / BL21-DE3 [Austria].
[3]"Complete sequence of Escherichia coli BL21(DE3)."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., LaButti K.M., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Sorek R., Rubin E.
Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: B / BL21-DE3 [JGI].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001665 Genomic DNA. Translation: ACT29588.1.
CP001509 Genomic DNA. Translation: ACT42925.1.
AM946981 Genomic DNA. Translation: CAQ31554.1.

3D structure databases

ProteinModelPortalC6EHH9.
SMRC6EHH9. Positions 1-312.
ModBaseSearch...

Protein-protein interaction databases

STRINGC6EHH9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000159210; EBESCP00000146311; EBESCG00000157469.
EBESCT00000188366; EBESCP00000178857; EBESCG00000188908.
EBESCT00000195421; EBESCP00000181429; EBESCG00000191741.
GenomeReviewsGene locus B21_01037 in contig AM946981_GR.
Gene locus ECD_01030 in contig CP001509_GR.
Gene locus ECBD_2566 in contig CP001665_GR.
KEGGebd:ECBD_2566.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000009080.
OMAEYVTHAV.
ProtClustDBPRK15469.

Family and domain databases

HAMAPMF_01666. 2_Hacid_dh_C_GhrA.
[Tree]
InterProIPR006140. D-isomer_2_OHA_DH_NAD-bd.
IPR023514. GhrA.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK12972.
PfamPF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEPS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC6EHH9_ECOBD
AccessionPrimary (citable) accession number: C6EHH9
Secondary accession number(s): C5W308
Entry history
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info