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C6EA03 (C6EA03_ECOBD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome c-type biogenesis protein CcmE HAMAP-Rule MF_01959
Alternative name(s):
Cytochrome c maturation protein E HAMAP-Rule MF_01959
Heme chaperone CcmE HAMAP-Rule MF_01959
Gene names
Name:ccmE HAMAP-Rule MF_01959 EMBL ACT43947.1
Synonyms:cycJ HAMAP-Rule MF_01959
Ordered Locus Names:B21_02083, ECBD_1463, ECD_02124
OrganismEscherichia coli (strain B / BL21-DE3) [Complete proteome] [HAMAP]
Taxonomic identifier469008 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length159 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH By similarity. SAAS SAAS004329 HAMAP-Rule MF_01959

Subcellular location

Cell inner membrane; Single-pass type II membrane protein; Periplasmic side By similarity HAMAP-Rule MF_01959.

Sequence similarities

Belongs to the CcmE/CycJ family. HAMAP-Rule MF_01959

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential EMBL ACT28525.1
Chain31 – 159129 Potential EMBL ACT28525.1
PRO_5000487375

Regions

Topological domain1 – 88Cytoplasmic By similarity HAMAP-Rule MF_01959
Transmembrane9 – 2921Helical; Signal-anchor for type II membrane protein; By similarity HAMAP-Rule MF_01959
Topological domain30 – 159130Periplasmic By similarity HAMAP-Rule MF_01959

Sites

Metal binding1341Iron (heme axial ligand) By similarity HAMAP-Rule MF_01959
Binding site1301Heme (covalent; via pros nitrogen) By similarity HAMAP-Rule MF_01959

Sequences

Sequence LengthMass (Da)Tools
C6EA03 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: FA0585B8CD6446FC

FASTA15917,698
        10         20         30         40         50         60 
MNIRRKNRLW IACAVLAGLA LTIGLVLYAL RSNIDLFYTP GEILYGKRET QQMPEVGQRL 

        70         80         90        100        110        120 
RVGGMVMPGS VQRDPNSLKV TFTIYDAEGS VDVSYEGILP DLFREGQGVV VQGELEKGNH 

       130        140        150 
ILAKEVLAKH DENYTPPEVE KAMEANHRRP ASVYKDPAS

« Hide

References

[1]"Genome sequences of Escherichia coli B strains REL606 and BL21(DE3)."
Jeong H., Barbe V., Lee C.H., Vallenet D., Yu D.S., Choi S.H., Couloux A., Lee S.W., Yoon S.H., Cattolico L., Hur C.G., Park H.S., Segurens B., Kim S.C., Oh T.K., Lenski R.E., Studier F.W., Daegelen P., Kim J.F.
J. Mol. Biol. 394:644-652(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: B / BL21-DE3 [Korea].
[2]"Sequencing and gene expression analysis of Escherichia coli BL21."
Leparc G., Striedner G., Bayer K., Kreil D., Krempl P.M.
Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: B / BL21-DE3 [Austria].
[3]"Complete sequence of Escherichia coli BL21(DE3)."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., LaButti K.M., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Sorek R., Rubin E.
Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: B / BL21-DE3 [JGI].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001665 Genomic DNA. Translation: ACT28525.1.
CP001509 Genomic DNA. Translation: ACT43947.1.
AM946981 Genomic DNA. Translation: CAQ32600.1.
RefSeqYP_002999864.1. NC_012892.2.
YP_003035710.1. NC_012947.1.
YP_003054718.1. NC_012971.2.

3D structure databases

SMRC6EA03. Positions 30-143.
ModBaseSearch...

Protein-protein interaction databases

STRING469008.ECBD_1463.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACT28525; ACT28525; ECBD_1463.
ACT43947; ACT43947; ECD_02124.
CAQ32600; CAQ32600; B21_02083.
GeneID8113102.
8159998.
8183002.
KEGGebd:ECBD_1463.
ebe:B21_02083.
ebl:ECD_02124.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2332.
HOGENOMHOG000009661.
KOK02197.
OMAFYTPSQI.
ProtClustDBPRK13165.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
HAMAPMF_01959. CcmE.
InterProIPR004329. CcmE.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF03100. CcmE. 1 hit.
[Graphical view]
SUPFAMSSF82093. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC6EA03_ECOBD
AccessionPrimary (citable) accession number: C6EA03
Secondary accession number(s): C5W6T7
Entry history
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info