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C6E7R9

- DCUP_GEOSM

UniProt

C6E7R9 - DCUP_GEOSM

Protein

Uroporphyrinogen decarboxylase

Gene

hemE

Organism
Geobacter sp. (strain M21)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.UniRule annotation

    Catalytic activityi

    Uroporphyrinogen III = coproporphyrinogen + 4 CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei72 – 721SubstrateUniRule annotation
    Sitei72 – 721Transition state stabilizerUniRule annotation
    Binding sitei147 – 1471SubstrateUniRule annotation
    Binding sitei202 – 2021SubstrateUniRule annotation
    Binding sitei315 – 3151SubstrateUniRule annotation

    GO - Molecular functioni

    1. uroporphyrinogen decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Enzyme and pathway databases

    BioCyciGSP443144:GHKM-15-MONOMER.
    UniPathwayiUPA00251; UER00321.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uroporphyrinogen decarboxylaseUniRule annotation (EC:4.1.1.37UniRule annotation)
    Short name:
    UPDUniRule annotation
    Short name:
    URO-DUniRule annotation
    Gene namesi
    Name:hemEUniRule annotation
    Ordered Locus Names:GM21_0015
    OrganismiGeobacter sp. (strain M21)
    Taxonomic identifieri443144 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000002380: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Uroporphyrinogen decarboxylasePRO_1000204232Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi443144.GM21_0015.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni23 – 275Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the uroporphyrinogen decarboxylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0407.
    HOGENOMiHOG000253897.
    KOiK01599.
    OMAiGSSKDFR.
    OrthoDBiEOG6VXF6H.

    Family and domain databases

    HAMAPiMF_00218. URO_D.
    InterProiIPR006361. Uroporphyrinogen_deCO2ase_HemE.
    IPR000257. Uroporphyrinogen_deCOase.
    [Graphical view]
    PfamiPF01208. URO-D. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01464. hemE. 1 hit.
    PROSITEiPS00906. UROD_1. 1 hit.
    PS00907. UROD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C6E7R9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTRFLDACW GKPVDTVPVW LMRQAGRYLP DYMRVRSKCT FLELCKTPEL    50
    ATEVTVQPVD ILGVDAAILF SDILTPIEPM GMELDFTPGP VFAKPIRTMA 100
    DVEALKIPKM ETDVPYVLDA VKLLRKELAA KVPLIGFGGA PFTLACYMVE 150
    GKGSKDFAAL KKMMYADPEV YAALMEKITT MDMEYLNAQI KAGAQAIQIF 200
    DTWGGMLSPA DYERYVLPYT QRLINGLDRT NIPVIHFVKG AGTMLEIVKQ 250
    AGGDVMGLDW HVNLGKARDI LGDMAVQGNL DPTVLFAPNE IIEREVKRVL 300
    DENAGRPGLI FNLGHGILPT VPPEKAIFMV DCVHRLSRK 339
    Length:339
    Mass (Da):37,591
    Last modified:September 1, 2009 - v1
    Checksum:i58B7FD44FF037962
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001661 Genomic DNA. Translation: ACT16102.1.
    RefSeqiWP_012773730.1. NC_012918.1.
    YP_003019860.1. NC_012918.1.

    Genome annotation databases

    EnsemblBacteriaiACT16102; ACT16102; GM21_0015.
    GeneIDi8135314.
    KEGGigem:GM21_0015.
    PATRICi22014512. VBIGeoSp56140_0016.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001661 Genomic DNA. Translation: ACT16102.1 .
    RefSeqi WP_012773730.1. NC_012918.1.
    YP_003019860.1. NC_012918.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 443144.GM21_0015.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACT16102 ; ACT16102 ; GM21_0015 .
    GeneIDi 8135314.
    KEGGi gem:GM21_0015.
    PATRICi 22014512. VBIGeoSp56140_0016.

    Phylogenomic databases

    eggNOGi COG0407.
    HOGENOMi HOG000253897.
    KOi K01599.
    OMAi GSSKDFR.
    OrthoDBi EOG6VXF6H.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00321 .
    BioCyci GSP443144:GHKM-15-MONOMER.

    Family and domain databases

    HAMAPi MF_00218. URO_D.
    InterProi IPR006361. Uroporphyrinogen_deCO2ase_HemE.
    IPR000257. Uroporphyrinogen_deCOase.
    [Graphical view ]
    Pfami PF01208. URO-D. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01464. hemE. 1 hit.
    PROSITEi PS00906. UROD_1. 1 hit.
    PS00907. UROD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: M21.

    Entry informationi

    Entry nameiDCUP_GEOSM
    AccessioniPrimary (citable) accession number: C6E7R9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3