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C6E7R9

- DCUP_GEOSM

UniProt

C6E7R9 - DCUP_GEOSM

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Protein

Uroporphyrinogen decarboxylase

Gene

hemE

Organism
Geobacter sp. (strain M21)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.UniRule annotation

Catalytic activityi

Uroporphyrinogen III = coproporphyrinogen + 4 CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721SubstrateUniRule annotation
Sitei72 – 721Transition state stabilizerUniRule annotation
Binding sitei147 – 1471SubstrateUniRule annotation
Binding sitei202 – 2021SubstrateUniRule annotation
Binding sitei315 – 3151SubstrateUniRule annotation

GO - Molecular functioni

  1. uroporphyrinogen decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciGSP443144:GHKM-15-MONOMER.
UniPathwayiUPA00251; UER00321.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen decarboxylaseUniRule annotation (EC:4.1.1.37UniRule annotation)
Short name:
UPDUniRule annotation
Short name:
URO-DUniRule annotation
Gene namesi
Name:hemEUniRule annotation
Ordered Locus Names:GM21_0015
OrganismiGeobacter sp. (strain M21)
Taxonomic identifieri443144 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000002380: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Uroporphyrinogen decarboxylasePRO_1000204232Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi443144.GM21_0015.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 275Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the uroporphyrinogen decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0407.
HOGENOMiHOG000253897.
KOiK01599.
OMAiGSSKDFR.
OrthoDBiEOG6VXF6H.

Family and domain databases

HAMAPiMF_00218. URO_D.
InterProiIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PfamiPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01464. hemE. 1 hit.
PROSITEiPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6E7R9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTRFLDACW GKPVDTVPVW LMRQAGRYLP DYMRVRSKCT FLELCKTPEL
60 70 80 90 100
ATEVTVQPVD ILGVDAAILF SDILTPIEPM GMELDFTPGP VFAKPIRTMA
110 120 130 140 150
DVEALKIPKM ETDVPYVLDA VKLLRKELAA KVPLIGFGGA PFTLACYMVE
160 170 180 190 200
GKGSKDFAAL KKMMYADPEV YAALMEKITT MDMEYLNAQI KAGAQAIQIF
210 220 230 240 250
DTWGGMLSPA DYERYVLPYT QRLINGLDRT NIPVIHFVKG AGTMLEIVKQ
260 270 280 290 300
AGGDVMGLDW HVNLGKARDI LGDMAVQGNL DPTVLFAPNE IIEREVKRVL
310 320 330
DENAGRPGLI FNLGHGILPT VPPEKAIFMV DCVHRLSRK
Length:339
Mass (Da):37,591
Last modified:September 1, 2009 - v1
Checksum:i58B7FD44FF037962
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001661 Genomic DNA. Translation: ACT16102.1.
RefSeqiWP_012773730.1. NC_012918.1.
YP_003019860.1. NC_012918.1.

Genome annotation databases

EnsemblBacteriaiACT16102; ACT16102; GM21_0015.
GeneIDi8135314.
KEGGigem:GM21_0015.
PATRICi22014512. VBIGeoSp56140_0016.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001661 Genomic DNA. Translation: ACT16102.1 .
RefSeqi WP_012773730.1. NC_012918.1.
YP_003019860.1. NC_012918.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 443144.GM21_0015.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACT16102 ; ACT16102 ; GM21_0015 .
GeneIDi 8135314.
KEGGi gem:GM21_0015.
PATRICi 22014512. VBIGeoSp56140_0016.

Phylogenomic databases

eggNOGi COG0407.
HOGENOMi HOG000253897.
KOi K01599.
OMAi GSSKDFR.
OrthoDBi EOG6VXF6H.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00321 .
BioCyci GSP443144:GHKM-15-MONOMER.

Family and domain databases

HAMAPi MF_00218. URO_D.
InterProi IPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view ]
Pfami PF01208. URO-D. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01464. hemE. 1 hit.
PROSITEi PS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M21.

Entry informationi

Entry nameiDCUP_GEOSM
AccessioniPrimary (citable) accession number: C6E7R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3