Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

C6E7R9 (DCUP_GEOSM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase

Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:GM21_0015
OrganismGeobacter sp. (strain M21) [Complete proteome] [HAMAP]
Taxonomic identifier443144 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP-Rule MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP-Rule MF_00218

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP-Rule MF_00218

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00218

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotoporphyrinogen IX biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Uroporphyrinogen decarboxylase HAMAP-Rule MF_00218
PRO_1000204232

Regions

Region23 – 275Substrate binding By similarity

Sites

Binding site721Substrate By similarity
Binding site1471Substrate By similarity
Binding site2021Substrate By similarity
Binding site3151Substrate By similarity
Site721Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
C6E7R9 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: 58B7FD44FF037962

FASTA33937,591
        10         20         30         40         50         60 
MNTRFLDACW GKPVDTVPVW LMRQAGRYLP DYMRVRSKCT FLELCKTPEL ATEVTVQPVD 

        70         80         90        100        110        120 
ILGVDAAILF SDILTPIEPM GMELDFTPGP VFAKPIRTMA DVEALKIPKM ETDVPYVLDA 

       130        140        150        160        170        180 
VKLLRKELAA KVPLIGFGGA PFTLACYMVE GKGSKDFAAL KKMMYADPEV YAALMEKITT 

       190        200        210        220        230        240 
MDMEYLNAQI KAGAQAIQIF DTWGGMLSPA DYERYVLPYT QRLINGLDRT NIPVIHFVKG 

       250        260        270        280        290        300 
AGTMLEIVKQ AGGDVMGLDW HVNLGKARDI LGDMAVQGNL DPTVLFAPNE IIEREVKRVL 

       310        320        330 
DENAGRPGLI FNLGHGILPT VPPEKAIFMV DCVHRLSRK 

« Hide

References

[1]"Complete sequence of Geobacter sp. M21."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Lovley D.
Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: M21.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001661 Genomic DNA. Translation: ACT16102.1.
RefSeqYP_003019860.1. NC_012918.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING443144.GM21_0015.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACT16102; ACT16102; GM21_0015.
GeneID8135314.
KEGGgem:GM21_0015.
PATRIC22014512. VBIGeoSp56140_0016.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0407.
HOGENOMHOG000253897.
KOK01599.
OMATLATYMI.
OrthoDBEOG6VXF6H.
ProtClustDBPRK00115.

Enzyme and pathway databases

BioCycGSP443144:GHKM-15-MONOMER.
UniPathwayUPA00251; UER00321.

Family and domain databases

HAMAPMF_00218. URO_D.
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PANTHERPTHR21091:SF2. PTHR21091:SF2. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. hemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_GEOSM
AccessionPrimary (citable) accession number: C6E7R9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: February 19, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways