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Protein

Uroporphyrinogen decarboxylase

Gene

hemE

Organism
Geobacter sp. (strain M21)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.UniRule annotation

Catalytic activityi

Uroporphyrinogen III = coproporphyrinogen + 4 CO2.UniRule annotation

Pathway: protoporphyrin-IX biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Porphobilinogen deaminase (hemC)
  3. no protein annotated in this organism
  4. Uroporphyrinogen decarboxylase (hemE)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721SubstrateUniRule annotation
Sitei72 – 721Transition state stabilizerUniRule annotation
Binding sitei147 – 1471SubstrateUniRule annotation
Binding sitei202 – 2021SubstrateUniRule annotation
Binding sitei315 – 3151SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciGSP443144:GHKM-15-MONOMER.
UniPathwayiUPA00251; UER00321.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen decarboxylaseUniRule annotation (EC:4.1.1.37UniRule annotation)
Short name:
UPDUniRule annotation
Short name:
URO-DUniRule annotation
Gene namesi
Name:hemEUniRule annotation
Ordered Locus Names:GM21_0015
OrganismiGeobacter sp. (strain M21)
Taxonomic identifieri443144 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000002380 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Uroporphyrinogen decarboxylasePRO_1000204232Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi443144.GM21_0015.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 275Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the uroporphyrinogen decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0407.
HOGENOMiHOG000253897.
KOiK01599.
OMAiPLIHFGT.
OrthoDBiEOG6VXF6H.

Family and domain databases

HAMAPiMF_00218. URO_D.
InterProiIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PfamiPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01464. hemE. 1 hit.
PROSITEiPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6E7R9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTRFLDACW GKPVDTVPVW LMRQAGRYLP DYMRVRSKCT FLELCKTPEL
60 70 80 90 100
ATEVTVQPVD ILGVDAAILF SDILTPIEPM GMELDFTPGP VFAKPIRTMA
110 120 130 140 150
DVEALKIPKM ETDVPYVLDA VKLLRKELAA KVPLIGFGGA PFTLACYMVE
160 170 180 190 200
GKGSKDFAAL KKMMYADPEV YAALMEKITT MDMEYLNAQI KAGAQAIQIF
210 220 230 240 250
DTWGGMLSPA DYERYVLPYT QRLINGLDRT NIPVIHFVKG AGTMLEIVKQ
260 270 280 290 300
AGGDVMGLDW HVNLGKARDI LGDMAVQGNL DPTVLFAPNE IIEREVKRVL
310 320 330
DENAGRPGLI FNLGHGILPT VPPEKAIFMV DCVHRLSRK
Length:339
Mass (Da):37,591
Last modified:September 1, 2009 - v1
Checksum:i58B7FD44FF037962
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001661 Genomic DNA. Translation: ACT16102.1.
RefSeqiWP_012773730.1. NC_012918.1.
YP_003019860.1. NC_012918.1.

Genome annotation databases

EnsemblBacteriaiACT16102; ACT16102; GM21_0015.
KEGGigem:GM21_0015.
PATRICi22014512. VBIGeoSp56140_0016.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001661 Genomic DNA. Translation: ACT16102.1.
RefSeqiWP_012773730.1. NC_012918.1.
YP_003019860.1. NC_012918.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi443144.GM21_0015.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACT16102; ACT16102; GM21_0015.
KEGGigem:GM21_0015.
PATRICi22014512. VBIGeoSp56140_0016.

Phylogenomic databases

eggNOGiCOG0407.
HOGENOMiHOG000253897.
KOiK01599.
OMAiPLIHFGT.
OrthoDBiEOG6VXF6H.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00321.
BioCyciGSP443144:GHKM-15-MONOMER.

Family and domain databases

HAMAPiMF_00218. URO_D.
InterProiIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PfamiPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01464. hemE. 1 hit.
PROSITEiPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M21.

Entry informationi

Entry nameiDCUP_GEOSM
AccessioniPrimary (citable) accession number: C6E7R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: April 29, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.