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C6E7E6

- GCH4_GEOSM

UniProt

C6E7E6 - GCH4_GEOSM

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Geobacter sp. (strain M21)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei154 – 1541May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciGSP443144:GHKM-3863-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:GM21_3787
OrganismiGeobacter sp. (strain M21)
Taxonomic identifieri443144 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000002380: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267GTP cyclohydrolase FolE2PRO_1000215391Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi443144.GM21_3787.

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

C6E7E6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKEYLKKPS LSDVQLTRDT RNIPIGKVGV KDISYPIVVM DKNKSFQNTI
60 70 80 90 100
ARINMYVDLP HHFKGTHMSR FVEILNEYRE EIALDKLELI LSTMKEKLGA
110 120 130 140 150
SNAHLEMEFP YFVEKTAPVS RAKSLMEYTC TFSASLSDRF DFVLGIKVPV
160 170 180 190 200
TSLCPCSKEL SSYGAHNQRS IMTVQVRYSE FIWIEDLIDI IEECGSSPVY
210 220 230 240 250
SLLKREDEKF VTERAYENPR FVEDMVREAT VRLLNMQNIS WFSVEAENFE
260
SIHKHSAYAA IERSRES
Length:267
Mass (Da):30,904
Last modified:September 1, 2009 - v1
Checksum:i26886986732ED9FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001661 Genomic DNA. Translation: ACT19806.1.
RefSeqiWP_015838989.1. NC_012918.1.
YP_003023564.1. NC_012918.1.

Genome annotation databases

EnsemblBacteriaiACT19806; ACT19806; GM21_3787.
GeneIDi8139161.
KEGGigem:GM21_3787.
PATRICi22022020. VBIGeoSp56140_3700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001661 Genomic DNA. Translation: ACT19806.1 .
RefSeqi WP_015838989.1. NC_012918.1.
YP_003023564.1. NC_012918.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 443144.GM21_3787.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACT19806 ; ACT19806 ; GM21_3787 .
GeneIDi 8139161.
KEGGi gem:GM21_3787.
PATRICi 22022020. VBIGeoSp56140_3700.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci GSP443144:GHKM-3863-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M21.

Entry informationi

Entry nameiGCH4_GEOSM
AccessioniPrimary (citable) accession number: C6E7E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: October 1, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3