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C6E7E6

- GCH4_GEOSM

UniProt

C6E7E6 - GCH4_GEOSM

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Geobacter sp. (strain M21)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei154 – 1541May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciGSP443144:GHKM-3863-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:GM21_3787
    OrganismiGeobacter sp. (strain M21)
    Taxonomic identifieri443144 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000002380: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 267267GTP cyclohydrolase FolE2PRO_1000215391Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi443144.GM21_3787.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C6E7E6-1 [UniParc]FASTAAdd to Basket

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    MIKEYLKKPS LSDVQLTRDT RNIPIGKVGV KDISYPIVVM DKNKSFQNTI    50
    ARINMYVDLP HHFKGTHMSR FVEILNEYRE EIALDKLELI LSTMKEKLGA 100
    SNAHLEMEFP YFVEKTAPVS RAKSLMEYTC TFSASLSDRF DFVLGIKVPV 150
    TSLCPCSKEL SSYGAHNQRS IMTVQVRYSE FIWIEDLIDI IEECGSSPVY 200
    SLLKREDEKF VTERAYENPR FVEDMVREAT VRLLNMQNIS WFSVEAENFE 250
    SIHKHSAYAA IERSRES 267
    Length:267
    Mass (Da):30,904
    Last modified:September 1, 2009 - v1
    Checksum:i26886986732ED9FE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001661 Genomic DNA. Translation: ACT19806.1.
    RefSeqiWP_015838989.1. NC_012918.1.
    YP_003023564.1. NC_012918.1.

    Genome annotation databases

    EnsemblBacteriaiACT19806; ACT19806; GM21_3787.
    GeneIDi8139161.
    KEGGigem:GM21_3787.
    PATRICi22022020. VBIGeoSp56140_3700.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001661 Genomic DNA. Translation: ACT19806.1 .
    RefSeqi WP_015838989.1. NC_012918.1.
    YP_003023564.1. NC_012918.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 443144.GM21_3787.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACT19806 ; ACT19806 ; GM21_3787 .
    GeneIDi 8139161.
    KEGGi gem:GM21_3787.
    PATRICi 22022020. VBIGeoSp56140_3700.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci GSP443144:GHKM-3863-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: M21.

    Entry informationi

    Entry nameiGCH4_GEOSM
    AccessioniPrimary (citable) accession number: C6E7E6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3