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C6E6M9

- PUR5_GEOSM

UniProt

C6E6M9 - PUR5_GEOSM

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Geobacter sp. (strain M21)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGSP443144:GHKM-1849-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:GM21_1817
OrganismiGeobacter sp. (strain M21)
Taxonomic identifieri443144 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000002380: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000212823Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi443144.GM21_1817.

Structurei

3D structure databases

ProteinModelPortaliC6E6M9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiEFEMYRT.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

C6E6M9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKETKITYKD AGVDIDAGNT FVQMIKPLVK ATSRPEVLAD IGGFGGLFSL
60 70 80 90 100
NMGKYKHPVL VSGTDGVGTK LKLAFLADRH DTIGIDLVAM CVNDIIVQGA
110 120 130 140 150
EPLFFLDYLA TAKLDPVKAA SIIKGVSEGC VQAGCALIGG ETAEMPGFYT
160 170 180 190 200
GDEYDMAGFA VGVVEREKII DGSSITVGNR LIGLASSGLH SNGYSLARKV
210 220 230 240 250
ILEHMGLGID DELPGLGKTV AEELLTPTRI YVRSVMNLLR DFNISGLAHI
260 270 280 290 300
TGGGLLENIP RVLPNGCKAV IKKESWEVPE IFRIMQKAGN IEENEMFRTF
310 320 330 340
NCGIGMVLVV PEKEAEEIMI RLSGLNETAF VIGEVAKCDA GKECVELV
Length:348
Mass (Da):37,269
Last modified:September 1, 2009 - v1
Checksum:iFF22A9F72BD3A1C8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001661 Genomic DNA. Translation: ACT17870.1.
RefSeqiWP_015837115.1. NC_012918.1.
YP_003021628.1. NC_012918.1.

Genome annotation databases

EnsemblBacteriaiACT17870; ACT17870; GM21_1817.
GeneIDi8137148.
KEGGigem:GM21_1817.
PATRICi22018068. VBIGeoSp56140_1766.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001661 Genomic DNA. Translation: ACT17870.1 .
RefSeqi WP_015837115.1. NC_012918.1.
YP_003021628.1. NC_012918.1.

3D structure databases

ProteinModelPortali C6E6M9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 443144.GM21_1817.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACT17870 ; ACT17870 ; GM21_1817 .
GeneIDi 8137148.
KEGGi gem:GM21_1817.
PATRICi 22018068. VBIGeoSp56140_1766.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi EFEMYRT.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci GSP443144:GHKM-1849-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M21.

Entry informationi

Entry nameiPUR5_GEOSM
AccessioniPrimary (citable) accession number: C6E6M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3