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C6E6M9

- PUR5_GEOSM

UniProt

C6E6M9 - PUR5_GEOSM

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Geobacter sp. (strain M21)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciGSP443144:GHKM-1849-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:GM21_1817
    OrganismiGeobacter sp. (strain M21)
    Taxonomic identifieri443144 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000002380: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 348348Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000212823Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi443144.GM21_1817.

    Structurei

    3D structure databases

    ProteinModelPortaliC6E6M9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229091.
    KOiK01933.
    OMAiEFEMYRT.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C6E6M9-1 [UniParc]FASTAAdd to Basket

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    MKETKITYKD AGVDIDAGNT FVQMIKPLVK ATSRPEVLAD IGGFGGLFSL    50
    NMGKYKHPVL VSGTDGVGTK LKLAFLADRH DTIGIDLVAM CVNDIIVQGA 100
    EPLFFLDYLA TAKLDPVKAA SIIKGVSEGC VQAGCALIGG ETAEMPGFYT 150
    GDEYDMAGFA VGVVEREKII DGSSITVGNR LIGLASSGLH SNGYSLARKV 200
    ILEHMGLGID DELPGLGKTV AEELLTPTRI YVRSVMNLLR DFNISGLAHI 250
    TGGGLLENIP RVLPNGCKAV IKKESWEVPE IFRIMQKAGN IEENEMFRTF 300
    NCGIGMVLVV PEKEAEEIMI RLSGLNETAF VIGEVAKCDA GKECVELV 348
    Length:348
    Mass (Da):37,269
    Last modified:September 1, 2009 - v1
    Checksum:iFF22A9F72BD3A1C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001661 Genomic DNA. Translation: ACT17870.1.
    RefSeqiWP_015837115.1. NC_012918.1.
    YP_003021628.1. NC_012918.1.

    Genome annotation databases

    EnsemblBacteriaiACT17870; ACT17870; GM21_1817.
    GeneIDi8137148.
    KEGGigem:GM21_1817.
    PATRICi22018068. VBIGeoSp56140_1766.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001661 Genomic DNA. Translation: ACT17870.1 .
    RefSeqi WP_015837115.1. NC_012918.1.
    YP_003021628.1. NC_012918.1.

    3D structure databases

    ProteinModelPortali C6E6M9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 443144.GM21_1817.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACT17870 ; ACT17870 ; GM21_1817 .
    GeneIDi 8137148.
    KEGGi gem:GM21_1817.
    PATRICi 22018068. VBIGeoSp56140_1766.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229091.
    KOi K01933.
    OMAi EFEMYRT.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci GSP443144:GHKM-1849-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: M21.

    Entry informationi

    Entry nameiPUR5_GEOSM
    AccessioniPrimary (citable) accession number: C6E6M9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3