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C6E6I5

- NADK_GEOSM

UniProt

C6E6I5 - NADK_GEOSM

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Protein
NAD kinase
Gene
nadK, GM21_1772
Organism
Geobacter sp. (strain M21)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei70 – 701Proton acceptor By similarity
Binding sitei155 – 1551NAD By similarity
Binding sitei172 – 1721NAD By similarity
Binding sitei174 – 1741NAD By similarity
Binding sitei245 – 2451NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi70 – 712NAD By similarity
Nucleotide bindingi144 – 1452NAD By similarity
Nucleotide bindingi185 – 1906NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciGSP443144:GHKM-1804-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:GM21_1772
OrganismiGeobacter sp. (strain M21)
Taxonomic identifieri443144 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000002380: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288NAD kinaseUniRule annotation
PRO_1000205419Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi443144.GM21_1772.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiTHEMLYH.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

C6E6I5-1 [UniParc]FASTAAdd to Basket

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MKKIAIFAKV HDPRALAVAE ELIEWLAARG VTAHVEEHLS KRLRRTTLAE    50
SSESTEIAAD ADLVVVLGGD GTLIAAARLV GERDIPILAV NLGSLGFLTE 100
ITLDELYPSV ERCLAGDFEV TERMMLMASV ERSGEVVELH RVLNDVVINK 150
GALARIIDME TSVNCRYLTT FKADGLIVST PTGSTGYSLS ANGPILHPEL 200
ECISITPICP HTLTNRPVVV AADSHIAIKL NYAPDESVFL TLDGQVGMKL 250
LSGDVVQITK AAHVTRLIRS RSKDYFEVLR TKLKWGER 288
Length:288
Mass (Da):31,408
Last modified:September 1, 2009 - v1
Checksum:i8BB40DB31CB9AF31
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001661 Genomic DNA. Translation: ACT17826.1.
RefSeqiWP_015837071.1. NC_012918.1.
YP_003021584.1. NC_012918.1.

Genome annotation databases

EnsemblBacteriaiACT17826; ACT17826; GM21_1772.
GeneIDi8137103.
KEGGigem:GM21_1772.
PATRICi22017976. VBIGeoSp56140_1720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001661 Genomic DNA. Translation: ACT17826.1 .
RefSeqi WP_015837071.1. NC_012918.1.
YP_003021584.1. NC_012918.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 443144.GM21_1772.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACT17826 ; ACT17826 ; GM21_1772 .
GeneIDi 8137103.
KEGGi gem:GM21_1772.
PATRICi 22017976. VBIGeoSp56140_1720.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi THEMLYH.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci GSP443144:GHKM-1804-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M21.

Entry informationi

Entry nameiNADK_GEOSM
AccessioniPrimary (citable) accession number: C6E6I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: September 3, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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