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C6E6C5

- GMHA_GEOSM

UniProt

C6E6C5 - GMHA_GEOSM

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Protein

Phosphoheptose isomerase

Gene

gmhA

Organism
Geobacter sp. (strain M21)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

Catalytic activityi

D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi58 – 581ZincUniRule annotation
Metal bindingi62 – 621ZincUniRule annotation
Binding sitei62 – 621SubstrateUniRule annotation
Binding sitei122 – 1221SubstrateUniRule annotation
Metal bindingi169 – 1691ZincUniRule annotation
Binding sitei169 – 1691SubstrateUniRule annotation
Metal bindingi177 – 1771ZincUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. D-sedoheptulose 7-phosphate isomerase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-glycero-D-manno-heptose 7-phosphate biosynthetic process Source: UniProtKB-UniPathway
  2. lipopolysaccharide core region biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciGSP443144:GHKM-1744-MONOMER.
UniPathwayiUPA00041; UER00436.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoheptose isomeraseUniRule annotation (EC:5.3.1.28UniRule annotation)
Alternative name(s):
Sedoheptulose 7-phosphate isomeraseUniRule annotation
Gene namesi
Name:gmhAUniRule annotation
Ordered Locus Names:GM21_1712
OrganismiGeobacter sp. (strain M21)
Taxonomic identifieri443144 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000002380: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Phosphoheptose isomerasePRO_1000202420Add
BLAST

Proteomic databases

PRIDEiC6E6C5.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi443144.GM21_1712.

Structurei

3D structure databases

ProteinModelPortaliC6E6C5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 192159SISUniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni49 – 513Substrate bindingUniRule annotation
Regioni91 – 922Substrate bindingUniRule annotation
Regioni117 – 1193Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the SIS family. GmhA subfamily.UniRule annotation
Contains 1 SIS domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0279.
HOGENOMiHOG000237571.
KOiK03271.
OMAiHVFSRYV.
OrthoDBiEOG6384PC.

Family and domain databases

HAMAPiMF_00067. GmhA.
InterProiIPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
[Graphical view]
PfamiPF13580. SIS_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00441. gmhA. 1 hit.
PROSITEiPS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6E6C5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLEEIKAQLR AHCEVMTALQ GELSPAIESA VSLVVDAYRA GNKLLVMGNG
60 70 80 90 100
GSAADAQHFV AEMVGRFKLE RRALPAIALH TDTSILTAIG NDYGFDRIFS
110 120 130 140 150
RQVEAHAAAG DVVVGISTSG NSPNVQLALE LAREKGCRTV ALLGKDGGSI
160 170 180 190
KSVAELPLIV PSNDTPRIQE GHITIIHIIC DLVERELFLK GN
Length:192
Mass (Da):20,465
Last modified:September 1, 2009 - v1
Checksum:i68F0CA9844A89991
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001661 Genomic DNA. Translation: ACT17766.1.
RefSeqiWP_015837012.1. NC_012918.1.
YP_003021524.1. NC_012918.1.

Genome annotation databases

EnsemblBacteriaiACT17766; ACT17766; GM21_1712.
GeneIDi8137043.
KEGGigem:GM21_1712.
PATRICi22017856. VBIGeoSp56140_1660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001661 Genomic DNA. Translation: ACT17766.1 .
RefSeqi WP_015837012.1. NC_012918.1.
YP_003021524.1. NC_012918.1.

3D structure databases

ProteinModelPortali C6E6C5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 443144.GM21_1712.

Proteomic databases

PRIDEi C6E6C5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACT17766 ; ACT17766 ; GM21_1712 .
GeneIDi 8137043.
KEGGi gem:GM21_1712.
PATRICi 22017856. VBIGeoSp56140_1660.

Phylogenomic databases

eggNOGi COG0279.
HOGENOMi HOG000237571.
KOi K03271.
OMAi HVFSRYV.
OrthoDBi EOG6384PC.

Enzyme and pathway databases

UniPathwayi UPA00041 ; UER00436 .
BioCyci GSP443144:GHKM-1744-MONOMER.

Family and domain databases

HAMAPi MF_00067. GmhA.
InterProi IPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
[Graphical view ]
Pfami PF13580. SIS_2. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00441. gmhA. 1 hit.
PROSITEi PS51464. SIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M21.

Entry informationi

Entry nameiGMHA_GEOSM
AccessioniPrimary (citable) accession number: C6E6C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: November 26, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.UniRule annotation

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3