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Protein

Phosphoheptose isomerase

Gene

gmhA

Organism
Geobacter sp. (strain M21)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.UniRule annotation

Catalytic activityi

D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: D-glycero-D-manno-heptose 7-phosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Phosphoheptose isomerase (gmhA)
This subpathway is part of the pathway D-glycero-D-manno-heptose 7-phosphate biosynthesis, which is itself part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate, the pathway D-glycero-D-manno-heptose 7-phosphate biosynthesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi58ZincUniRule annotation1
Metal bindingi62ZincUniRule annotation1
Binding sitei62SubstrateUniRule annotation1
Binding sitei122SubstrateUniRule annotation1
Metal bindingi169ZincUniRule annotation1
Binding sitei169SubstrateUniRule annotation1
Metal bindingi177ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciGSP443144:G1GFA-1731-MONOMER
UniPathwayiUPA00041; UER00436

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoheptose isomeraseUniRule annotation (EC:5.3.1.28UniRule annotation)
Alternative name(s):
Sedoheptulose 7-phosphate isomeraseUniRule annotation
Gene namesi
Name:gmhAUniRule annotation
Ordered Locus Names:GM21_1712
OrganismiGeobacter sp. (strain M21)
Taxonomic identifieri443144 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000002380 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002024201 – 192Phosphoheptose isomeraseAdd BLAST192

Proteomic databases

PRIDEiC6E6C5

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi443144.GM21_1712

Structurei

3D structure databases

ProteinModelPortaliC6E6C5
SMRiC6E6C5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 192SISUniRule annotationAdd BLAST159

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 51Substrate bindingUniRule annotation3
Regioni91 – 92Substrate bindingUniRule annotation2
Regioni117 – 119Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the SIS family. GmhA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F55 Bacteria
COG0279 LUCA
HOGENOMiHOG000237571
KOiK03271
OMAiFLAHKEA
OrthoDBiPOG091H02G7

Family and domain databases

CDDicd05006 SIS_GmhA, 1 hit
HAMAPiMF_00067 GmhA, 1 hit
InterProiView protein in InterPro
IPR035461 GmhA/DiaA
IPR004515 Phosphoheptose_Isoase
IPR001347 SIS
PfamiView protein in Pfam
PF13580 SIS_2, 1 hit
TIGRFAMsiTIGR00441 gmhA, 1 hit
PROSITEiView protein in PROSITE
PS51464 SIS, 1 hit

Sequencei

Sequence statusi: Complete.

C6E6C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEEIKAQLR AHCEVMTALQ GELSPAIESA VSLVVDAYRA GNKLLVMGNG
60 70 80 90 100
GSAADAQHFV AEMVGRFKLE RRALPAIALH TDTSILTAIG NDYGFDRIFS
110 120 130 140 150
RQVEAHAAAG DVVVGISTSG NSPNVQLALE LAREKGCRTV ALLGKDGGSI
160 170 180 190
KSVAELPLIV PSNDTPRIQE GHITIIHIIC DLVERELFLK GN
Length:192
Mass (Da):20,465
Last modified:September 1, 2009 - v1
Checksum:i68F0CA9844A89991
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001661 Genomic DNA Translation: ACT17766.1
RefSeqiWP_015837012.1, NC_012918.1

Genome annotation databases

EnsemblBacteriaiACT17766; ACT17766; GM21_1712
KEGGigem:GM21_1712

Similar proteinsi

Entry informationi

Entry nameiGMHA_GEOSM
AccessioniPrimary (citable) accession number: C6E6C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: February 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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