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C6E6C5

- GMHA_GEOSM

UniProt

C6E6C5 - GMHA_GEOSM

Protein

Phosphoheptose isomerase

Gene

gmhA

Organism
Geobacter sp. (strain M21)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

    Catalytic activityi

    D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi58 – 581ZincUniRule annotation
    Metal bindingi62 – 621ZincUniRule annotation
    Binding sitei62 – 621SubstrateUniRule annotation
    Binding sitei122 – 1221SubstrateUniRule annotation
    Metal bindingi169 – 1691ZincUniRule annotation
    Binding sitei169 – 1691SubstrateUniRule annotation
    Metal bindingi177 – 1771ZincUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. D-sedoheptulose 7-phosphate isomerase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-glycero-D-manno-heptose 7-phosphate biosynthetic process Source: UniProtKB-UniPathway
    2. lipopolysaccharide core region biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciGSP443144:GHKM-1744-MONOMER.
    UniPathwayiUPA00041; UER00436.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoheptose isomeraseUniRule annotation (EC:5.3.1.28UniRule annotation)
    Alternative name(s):
    Sedoheptulose 7-phosphate isomeraseUniRule annotation
    Gene namesi
    Name:gmhAUniRule annotation
    Ordered Locus Names:GM21_1712
    OrganismiGeobacter sp. (strain M21)
    Taxonomic identifieri443144 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000002380: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 192192Phosphoheptose isomerasePRO_1000202420Add
    BLAST

    Proteomic databases

    PRIDEiC6E6C5.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi443144.GM21_1712.

    Structurei

    3D structure databases

    ProteinModelPortaliC6E6C5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 192159SISUniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni49 – 513Substrate bindingUniRule annotation
    Regioni91 – 922Substrate bindingUniRule annotation
    Regioni117 – 1193Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the SIS family. GmhA subfamily.UniRule annotation
    Contains 1 SIS domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0279.
    HOGENOMiHOG000237571.
    KOiK03271.
    OMAiHVFSRYV.
    OrthoDBiEOG6384PC.

    Family and domain databases

    HAMAPiMF_00067. GmhA.
    InterProiIPR004515. Phosphoheptose_Isoase.
    IPR001347. SIS.
    [Graphical view]
    PfamiPF13580. SIS_2. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00441. gmhA. 1 hit.
    PROSITEiPS51464. SIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C6E6C5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLEEIKAQLR AHCEVMTALQ GELSPAIESA VSLVVDAYRA GNKLLVMGNG    50
    GSAADAQHFV AEMVGRFKLE RRALPAIALH TDTSILTAIG NDYGFDRIFS 100
    RQVEAHAAAG DVVVGISTSG NSPNVQLALE LAREKGCRTV ALLGKDGGSI 150
    KSVAELPLIV PSNDTPRIQE GHITIIHIIC DLVERELFLK GN 192
    Length:192
    Mass (Da):20,465
    Last modified:September 1, 2009 - v1
    Checksum:i68F0CA9844A89991
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001661 Genomic DNA. Translation: ACT17766.1.
    RefSeqiWP_015837012.1. NC_012918.1.
    YP_003021524.1. NC_012918.1.

    Genome annotation databases

    EnsemblBacteriaiACT17766; ACT17766; GM21_1712.
    GeneIDi8137043.
    KEGGigem:GM21_1712.
    PATRICi22017856. VBIGeoSp56140_1660.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001661 Genomic DNA. Translation: ACT17766.1 .
    RefSeqi WP_015837012.1. NC_012918.1.
    YP_003021524.1. NC_012918.1.

    3D structure databases

    ProteinModelPortali C6E6C5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 443144.GM21_1712.

    Proteomic databases

    PRIDEi C6E6C5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACT17766 ; ACT17766 ; GM21_1712 .
    GeneIDi 8137043.
    KEGGi gem:GM21_1712.
    PATRICi 22017856. VBIGeoSp56140_1660.

    Phylogenomic databases

    eggNOGi COG0279.
    HOGENOMi HOG000237571.
    KOi K03271.
    OMAi HVFSRYV.
    OrthoDBi EOG6384PC.

    Enzyme and pathway databases

    UniPathwayi UPA00041 ; UER00436 .
    BioCyci GSP443144:GHKM-1744-MONOMER.

    Family and domain databases

    HAMAPi MF_00067. GmhA.
    InterProi IPR004515. Phosphoheptose_Isoase.
    IPR001347. SIS.
    [Graphical view ]
    Pfami PF13580. SIS_2. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00441. gmhA. 1 hit.
    PROSITEi PS51464. SIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: M21.

    Entry informationi

    Entry nameiGMHA_GEOSM
    AccessioniPrimary (citable) accession number: C6E6C5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.UniRule annotation

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3