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C6E5Z3

- PUR9_GEOSM

UniProt

C6E5Z3 - PUR9_GEOSM

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Geobacter sp. (strain M21)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciGSP443144:GHKM-3598-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:GM21_3524
OrganismiGeobacter sp. (strain M21)
Taxonomic identifieri443144 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000002380: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Bifunctional purine biosynthesis protein PurHPRO_1000203250Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi443144.GM21_3524.

Structurei

3D structure databases

ProteinModelPortaliC6E5Z3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

C6E5Z3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKIGRALIS VSEKTGVVEF SRALAGYGVE ILSTGGTAKL LREAGIAVKD
60 70 80 90 100
VSEFTGFPEM LDGRVKTLHP KVHGGILGMR ENPAHVAKMQ EHGIEPIDMV
110 120 130 140 150
VVNLYPFEAT VAKEDCTMED AIENIDIGGP TMLRSAAKNN RDVTVVVDHA
160 170 180 190 200
DYAVVLDEMK NSGGSVSCET NFRLAVKVYQ HTAAYDGAIS NWLGARTGDG
210 220 230 240 250
VAAFPDTLTL QYKLAQGMRY GENPHQSGAF YVEKGSKEAS ISTARQIQGK
260 270 280 290 300
ELSYNNIGDT DAALECVKQF TEPACVIVKH ANPCGVALGA NIMEAYDKAY
310 320 330 340 350
KTDPESSFGG IIAFNRELDE STARAIVERQ FVEVIIAPKV TEAASEVVAA
360 370 380 390 400
KKNVRLMECG FWPENPAPRF DYKRVNGGML VQDADLELFT ELKVVTKRAP
410 420 430 440 450
TDKEMEDLLF TWRVAKFVKS NAIVYGRDNS TVGVGAGQMS RVNSARIAAI
460 470 480 490 500
KAEHAGIPVQ GAVMASDAFF PFRDGLDNAA AVGVTAVIQP GGSMRDAEVI
510 520
AAADEHGIAM VFTAMRHFRH
Length:520
Mass (Da):56,072
Last modified:September 1, 2009 - v1
Checksum:i47CBE06BC7AB9135
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001661 Genomic DNA. Translation: ACT19545.1.
RefSeqiWP_015838730.1. NC_012918.1.
YP_003023303.1. NC_012918.1.

Genome annotation databases

EnsemblBacteriaiACT19545; ACT19545; GM21_3524.
GeneIDi8138896.
KEGGigem:GM21_3524.
PATRICi22021496. VBIGeoSp56140_3440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001661 Genomic DNA. Translation: ACT19545.1 .
RefSeqi WP_015838730.1. NC_012918.1.
YP_003023303.1. NC_012918.1.

3D structure databases

ProteinModelPortali C6E5Z3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 443144.GM21_3524.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACT19545 ; ACT19545 ; GM21_3524 .
GeneIDi 8138896.
KEGGi gem:GM21_3524.
PATRICi 22021496. VBIGeoSp56140_3440.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci GSP443144:GHKM-3598-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M21.

Entry informationi

Entry nameiPUR9_GEOSM
AccessioniPrimary (citable) accession number: C6E5Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: October 1, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3