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C6E3N2 (C6E3N2_GEOSM) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphofructokinase HAMAP-Rule MF_00339

Short name=Phosphofructokinase HAMAP-Rule MF_00339
EC=2.7.1.11 HAMAP-Rule MF_00339
Alternative name(s):
Phosphohexokinase HAMAP-Rule MF_00339
Gene names
Name:pfkA HAMAP-Rule MF_00339
Ordered Locus Names:GM21_1236 EMBL ACT17297.1
OrganismGeobacter sp. (strain M21) [Complete proteome] [HAMAP] EMBL ACT17297.1
Taxonomic identifier443144 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. HAMAP-Rule MF_00339

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. HAMAP-Rule MF_00339

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00339.

Sequence similarities

Belongs to the phosphofructokinase family. HAMAP-Rule MF_00339

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding22 – 265ATP By similarity HAMAP-Rule MF_00339
Nucleotide binding167 – 1715ATP By similarity HAMAP-Rule MF_00339
Nucleotide binding184 – 20017ATP By similarity HAMAP-Rule MF_00339

Sites

Active site1401Proton acceptor By similarity HAMAP-Rule MF_00339
Metal binding1981Magnesium; via carbonyl oxygen By similarity HAMAP-Rule MF_00339
Metal binding2001Magnesium By similarity HAMAP-Rule MF_00339
Binding site1751Substrate By similarity HAMAP-Rule MF_00339
Binding site2791Substrate By similarity HAMAP-Rule MF_00339
Binding site2851Substrate By similarity HAMAP-Rule MF_00339
Binding site2881Substrate By similarity HAMAP-Rule MF_00339

Sequences

Sequence LengthMass (Da)Tools
C6E3N2 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: 11AA3FFD91369527

FASTA36138,132
        10         20         30         40         50         60 
MGKKIGILTG GGDCPGLNAV IRGVVKSATG RGWEVVGIED GFDGFLHPEK CRCLGLEEVR 

        70         80         90        100        110        120 
GILPLGGTIL GTSNRGNPFA FPIVREGKVE LVDVSDEVCS RIEHLGLSAL IVVGGDGSLK 

       130        140        150        160        170        180 
IALEMMRRGV PIVGVPKTID NDLLETDVTF GYNTALETAT EALDKLHSTA ESHHRVMVLE 

       190        200        210        220        230        240 
VMGRYAGWIA LESGIAGGAD VILIPEIPYD IDKVSEAILA RGRRGRRFSV VVVAEGAFPK 

       250        260        270        280        290        300 
GGGRVVKEAA GGKSVVERLG GVGEAFSREL GGVLEMDIRV TVLGHLQRGG SPSTFDRCIG 

       310        320        330        340        350        360 
SRFGVKAVEL IESGAFGHMA CLKGRHVTSV PIEDAVRSLN LINPDGEMVR HAEALGIMLG 


R 

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References

[1]"Complete sequence of Geobacter sp. M21."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Lovley D.
Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: M21 EMBL ACT17297.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001661 Genomic DNA. Translation: ACT17297.1.
RefSeqYP_003021055.1. NC_012918.1.

3D structure databases

ProteinModelPortalC6E3N2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING443144.GM21_1236.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACT17297; ACT17297; GM21_1236.
GeneID8136561.
KEGGgem:GM21_1236.
PATRIC22016930. VBIGeoSp56140_1202.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0205.
HOGENOMHOG000248869.
KOK00850.
OMAIPEIPYK.
OrthoDBEOG644ZRM.
ProtClustDBCLSK828495.

Enzyme and pathway databases

BioCycGSP443144:GHKM-1262-MONOMER.
UniPathwayUPA00109; UER00182.

Family and domain databases

HAMAPMF_00339. Phosphofructokinase.
InterProIPR012003. ATP_PFK_prok.
IPR012829. PFK.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamPF00365. PFK. 1 hit.
[Graphical view]
PIRSFPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSPR00476. PHFRCTKINASE.
SUPFAMSSF53784. SSF53784. 1 hit.
TIGRFAMsTIGR02483. PFK_mixed. 1 hit.
PROSITEPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC6E3N2_GEOSM
AccessionPrimary (citable) accession number: C6E3N2
Entry history
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: April 16, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)