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C6E100

- SYL_GEOSM

UniProt

C6E100 - SYL_GEOSM

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Geobacter sp. (strain M21)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei584 – 5841ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciGSP443144:GHKM-782-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:GM21_0766
    OrganismiGeobacter sp. (strain M21)
    Taxonomic identifieri443144 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000002380: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 824824Leucine--tRNA ligasePRO_1000202220Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi443144.GM21_0766.

    Structurei

    3D structure databases

    ProteinModelPortaliC6E100.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi581 – 5855"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C6E100-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEKYNPSAV EEKWQGYWAE HESFKATEDP TRKKYYLLEM FPYPSGKIHM    50
    GHVRNYSIGD VIARFKRMQG YNVLHPMGWD AFGMPAENAA IQHKSHPAKW 100
    TYENIAYMRG QLKTLGLSYD WDRELATCDL DYYKWEQRIF LEMYKKGLAY 150
    KKSSAVNWCP KCETVLANEQ VEDGCCWRCD SPVRQKELEQ WSFRITNYAQ 200
    ELLDDTYKLT GWPERVLTMQ RNWIGRSTGC EIDFPLENGL GKIKVFTTRQ 250
    DTLFGATFMS LAAEHPMALD LAGDAQRAQV EAFIDKVKKT DRIKRGAEDL 300
    EKEGVFTGSY CVNPVTNTKM PIYLANFVLM DYGTGAVMAV PTHDQRDFEF 350
    AKKYNLPLKV VIQPEGETLD PAAMTEAYTA EGIMANSGRF DGMGNGDAKE 400
    AIADFLEKEG IGKKTVNFRL RDWGISRQRY WGNPIPVINC DLCGVVAVPE 450
    ADLPVVLPMD AEFTGEGGNP LARVDSFTTC TCPQCGEAAR RETDTMDTFV 500
    QSSWYFLRYC SPKFSAGPLD REKVEAWMPV DQYIGGIEHA VLHLLYARFF 550
    TKVLRDLGYC NVDEPFSNLL TQGMVIKDGA KMSKSKGNVV DPNALIERYG 600
    ADTARLFSLF AAPPEKDLDW SDQGVDGSYR FLNRVWRLVY DVLPVIGEAG 650
    AVNPDSLGAE AKKLRRAVHK TIKKVSEDVE ERFHFNTAIA AVMELVNAIQ 700
    AFAAKDAPEN VAVVREAVES VVRLLAPFVP HFAEELWSQL GHDTVLEAAG 750
    WPGYDAAAVV DEEVTVVIQV NGKLRSKLTV APDAKEEEVR AQALADDKIK 800
    PYLEGKDVKK VVYVPGKLVS IVVA 824
    Length:824
    Mass (Da):92,698
    Last modified:September 1, 2009 - v1
    Checksum:i873509B070F041FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001661 Genomic DNA. Translation: ACT16840.1.
    RefSeqiWP_012774457.1. NC_012918.1.
    YP_003020598.1. NC_012918.1.

    Genome annotation databases

    EnsemblBacteriaiACT16840; ACT16840; GM21_0766.
    GeneIDi8136081.
    KEGGigem:GM21_0766.
    PATRICi22016026. VBIGeoSp56140_0760.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001661 Genomic DNA. Translation: ACT16840.1 .
    RefSeqi WP_012774457.1. NC_012918.1.
    YP_003020598.1. NC_012918.1.

    3D structure databases

    ProteinModelPortali C6E100.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 443144.GM21_0766.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACT16840 ; ACT16840 ; GM21_0766 .
    GeneIDi 8136081.
    KEGGi gem:GM21_0766.
    PATRICi 22016026. VBIGeoSp56140_0760.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci GSP443144:GHKM-782-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: M21.

    Entry informationi

    Entry nameiSYL_GEOSM
    AccessioniPrimary (citable) accession number: C6E100
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3