Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Geobacter sp. (strain M21)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei584ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGSP443144:G1GFA-776-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:GM21_0766
OrganismiGeobacter sp. (strain M21)
Taxonomic identifieri443144 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000002380 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002022201 – 824Leucine--tRNA ligaseAdd BLAST824

Proteomic databases

PRIDEiC6E100

Interactioni

Protein-protein interaction databases

STRINGi443144.GM21_0766

Structurei

3D structure databases

ProteinModelPortaliC6E100
SMRiC6E100
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi581 – 585"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

C6E100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEKYNPSAV EEKWQGYWAE HESFKATEDP TRKKYYLLEM FPYPSGKIHM
60 70 80 90 100
GHVRNYSIGD VIARFKRMQG YNVLHPMGWD AFGMPAENAA IQHKSHPAKW
110 120 130 140 150
TYENIAYMRG QLKTLGLSYD WDRELATCDL DYYKWEQRIF LEMYKKGLAY
160 170 180 190 200
KKSSAVNWCP KCETVLANEQ VEDGCCWRCD SPVRQKELEQ WSFRITNYAQ
210 220 230 240 250
ELLDDTYKLT GWPERVLTMQ RNWIGRSTGC EIDFPLENGL GKIKVFTTRQ
260 270 280 290 300
DTLFGATFMS LAAEHPMALD LAGDAQRAQV EAFIDKVKKT DRIKRGAEDL
310 320 330 340 350
EKEGVFTGSY CVNPVTNTKM PIYLANFVLM DYGTGAVMAV PTHDQRDFEF
360 370 380 390 400
AKKYNLPLKV VIQPEGETLD PAAMTEAYTA EGIMANSGRF DGMGNGDAKE
410 420 430 440 450
AIADFLEKEG IGKKTVNFRL RDWGISRQRY WGNPIPVINC DLCGVVAVPE
460 470 480 490 500
ADLPVVLPMD AEFTGEGGNP LARVDSFTTC TCPQCGEAAR RETDTMDTFV
510 520 530 540 550
QSSWYFLRYC SPKFSAGPLD REKVEAWMPV DQYIGGIEHA VLHLLYARFF
560 570 580 590 600
TKVLRDLGYC NVDEPFSNLL TQGMVIKDGA KMSKSKGNVV DPNALIERYG
610 620 630 640 650
ADTARLFSLF AAPPEKDLDW SDQGVDGSYR FLNRVWRLVY DVLPVIGEAG
660 670 680 690 700
AVNPDSLGAE AKKLRRAVHK TIKKVSEDVE ERFHFNTAIA AVMELVNAIQ
710 720 730 740 750
AFAAKDAPEN VAVVREAVES VVRLLAPFVP HFAEELWSQL GHDTVLEAAG
760 770 780 790 800
WPGYDAAAVV DEEVTVVIQV NGKLRSKLTV APDAKEEEVR AQALADDKIK
810 820
PYLEGKDVKK VVYVPGKLVS IVVA
Length:824
Mass (Da):92,698
Last modified:September 1, 2009 - v1
Checksum:i873509B070F041FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001661 Genomic DNA Translation: ACT16840.1
RefSeqiWP_012774457.1, NC_012918.1

Genome annotation databases

EnsemblBacteriaiACT16840; ACT16840; GM21_0766
KEGGigem:GM21_0766

Similar proteinsi

Entry informationi

Entry nameiSYL_GEOSM
AccessioniPrimary (citable) accession number: C6E100
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health