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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Geobacter sp. (strain M21)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi253Magnesium or manganese 1UniRule annotation1
Metal bindingi266Magnesium or manganese 1UniRule annotation1
Metal bindingi266Magnesium or manganese 2UniRule annotation1
Metal bindingi268Magnesium or manganese 2UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi134 – 185ATPUniRule annotationAdd BLAST52

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGSP443144:G1GFA-521-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:GM21_0511
OrganismiGeobacter sp. (strain M21)
Taxonomic identifieri443144 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000002380 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002021991 – 305D-alanine--D-alanine ligaseAdd BLAST305

Interactioni

Protein-protein interaction databases

STRINGi443144.GM21_0511

Structurei

3D structure databases

ProteinModelPortaliC6DZK9
SMRiC6DZK9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 299ATP-graspUniRule annotationAdd BLAST193

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CPF Bacteria
COG1181 LUCA
HOGENOMiHOG000011592
KOiK01921
OMAiYETKYTE
OrthoDBiPOG091H00GT

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PIRSFiPIRSF039102 Ddl/VanB, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

C6DZK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVEELKKKK IAVLMGGLSA EREVSLNSGK AVLASLVRQG FQAVGIDVGR
60 70 80 90 100
DLPQRLAEEK AEVAFIALHG RFGEDGSVQG LLELMGIPYT GSGVLASALA
110 120 130 140 150
IDKIASKVIF ASAGLTLAPY QVLRRGEEFK LANPLPVVVK PSREGSSVGV
160 170 180 190 200
GIVRDPSRMQ AALDEAFRYD SEILIEGFID GREVQVGILD GKALGAIEIV
210 220 230 240 250
PKGEFYDYEA KYTDGGAQHI LPARLPEAVY GEVLRQGEKA HAALGCDCYS
260 270 280 290 300
RVDFLVTETG DCFLLEVNTL PGMTDLSLLP EIAGGAGITF GELVLRILQA

ASLKI
Length:305
Mass (Da):32,472
Last modified:September 1, 2009 - v1
Checksum:i0A72BEF188019CCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001661 Genomic DNA Translation: ACT16591.1
RefSeqiWP_012774214.1, NC_012918.1

Genome annotation databases

EnsemblBacteriaiACT16591; ACT16591; GM21_0511
KEGGigem:GM21_0511

Similar proteinsi

Entry informationi

Entry nameiDDL_GEOSM
AccessioniPrimary (citable) accession number: C6DZK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: February 28, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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