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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Geobacter sp. (strain M21)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciGSP443144:G1GFA-400-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:GM21_0391
OrganismiGeobacter sp. (strain M21)
Taxonomic identifieri443144 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000002380 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002126611 – 445Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST445

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi443144.GM21_0391

Structurei

3D structure databases

ProteinModelPortaliC6DYX1
SMRiC6DYX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

C6DYX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYCPNTPDE IREMLAVIGA GSIEELFAPI PAELRAKSFD LPPGMSEFEL
60 70 80 90 100
MRIMREKAAA GGAEILPFIG GGIYDHIIPA AVDHLSSRAE FYTAYTPYQP
110 120 130 140 150
ECSQGTLQAL FEYQTSICRL TGMEASNASL YDGGTAVAEA ALMSLRITER
160 170 180 190 200
NRVILDASVN PLHREIVTGY LHGLSAEAVE VAPDGCGSNL KALSGSIDEE
210 220 230 240 250
TAAVIVQNPN FFGSVQDFSE LALKAHEKGA LLIVSGYPIA LGLVASPGEM
260 270 280 290 300
GADIAVGDGQ SLGNPLSFGG PYFGFIAARK RFIRNLPGRI VGETIDNQGR
310 320 330 340 350
RGYVLTLQAR EQHIKRHKAT SNICSNQSLC ALRGLIFCAS LGKKGFEELA
360 370 380 390 400
LLNYDKAQYA KSRLSSLKGV TLMNAGTTFN EFTLSLPKDA APVVEKLLSF
410 420 430 440
GVAAGVPLGQ YYPGMDSALA VTVTEKRSKA EIDRLAALLE EALCS
Length:445
Mass (Da):47,522
Last modified:September 1, 2009 - v1
Checksum:i48F5FA3C55280C3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001661 Genomic DNA Translation: ACT16472.1
RefSeqiWP_012774098.1, NC_012918.1

Genome annotation databases

EnsemblBacteriaiACT16472; ACT16472; GM21_0391
KEGGigem:GM21_0391

Similar proteinsi

Entry informationi

Entry nameiGCSPA_GEOSM
AccessioniPrimary (citable) accession number: C6DYX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: April 25, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health