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C6DYX1 (GCSPA_GEOSM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:GM21_0391
OrganismGeobacter sp. (strain M21) [Complete proteome] [HAMAP]
Taxonomic identifier443144 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 445445Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000212661

Sequences

Sequence LengthMass (Da)Tools
C6DYX1 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: 48F5FA3C55280C3A

FASTA44547,522
        10         20         30         40         50         60 
MGYCPNTPDE IREMLAVIGA GSIEELFAPI PAELRAKSFD LPPGMSEFEL MRIMREKAAA 

        70         80         90        100        110        120 
GGAEILPFIG GGIYDHIIPA AVDHLSSRAE FYTAYTPYQP ECSQGTLQAL FEYQTSICRL 

       130        140        150        160        170        180 
TGMEASNASL YDGGTAVAEA ALMSLRITER NRVILDASVN PLHREIVTGY LHGLSAEAVE 

       190        200        210        220        230        240 
VAPDGCGSNL KALSGSIDEE TAAVIVQNPN FFGSVQDFSE LALKAHEKGA LLIVSGYPIA 

       250        260        270        280        290        300 
LGLVASPGEM GADIAVGDGQ SLGNPLSFGG PYFGFIAARK RFIRNLPGRI VGETIDNQGR 

       310        320        330        340        350        360 
RGYVLTLQAR EQHIKRHKAT SNICSNQSLC ALRGLIFCAS LGKKGFEELA LLNYDKAQYA 

       370        380        390        400        410        420 
KSRLSSLKGV TLMNAGTTFN EFTLSLPKDA APVVEKLLSF GVAAGVPLGQ YYPGMDSALA 

       430        440 
VTVTEKRSKA EIDRLAALLE EALCS 

« Hide

References

[1]"Complete sequence of Geobacter sp. M21."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Lovley D.
Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: M21.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001661 Genomic DNA. Translation: ACT16472.1.
RefSeqYP_003020230.1. NC_012918.1.

3D structure databases

ProteinModelPortalC6DYX1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING443144.GM21_0391.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACT16472; ACT16472; GM21_0391.
GeneID8135699.
KEGGgem:GM21_0391.
PATRIC22015266. VBIGeoSp56140_0386.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMARLVGQTE.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycGSP443144:GHKM-400-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_GEOSM
AccessionPrimary (citable) accession number: C6DYX1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families