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C6DVK9 (C6DVK9_MYCTK) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase RuleBase RU003410
EC=1.17.4.1 RuleBase RU003410
Gene names
Ordered Locus Names:TBMG_00917
OrganismMycobacterium tuberculosis (strain KZN 1435 / MDR) [Complete proteome] [HAMAP]
Taxonomic identifier478434 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex ›

Protein attributes

Sequence length725 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity. RuleBase RU003410

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. RuleBase RU003410

Pathway

Genetic information processing; DNA replication. RuleBase RU003410

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase large chain family. RuleBase RU003410

Sequences

Sequence LengthMass (Da)Tools
C6DVK9 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: 38C315D149331D55

FASTA72582,441
        10         20         30         40         50         60 
MPPTVIAEPV ASGAHASYSG GPGETDYHAL NAMLNLYDAD GKIQFDKDRE AAHQYFLQHV 

        70         80         90        100        110        120 
NQNTVFFHNQ DEKLDYLIRE NYYEREVLDQ YSRNFVKTLL DRAYAKKFRF PTFLGAFKYY 

       130        140        150        160        170        180 
TSYTLKTFDG KRYLERFEDR VVMVALTLAA GDTALAELLV DEIIDGRFQP ATPTFLNSGK 

       190        200        210        220        230        240 
KQRGEPVSCF LLRVEDNMES IGRSINSALQ LSKRGGGVAL LLTNIREHGA PIKNIENQSS 

       250        260        270        280        290        300 
GVIPIMKLLE DAFSYANQLG ARQGAGAVYL HAHHPDIYRF LDTKRENADE KIRIKTLSLG 

       310        320        330        340        350        360 
VVIPDITFEL AKRNDDMYLF SPYDVERVYG VPFADISVTE KYYEMVDDAR IRKTKIKARE 

       370        380        390        400        410        420 
FFQTLAELQF ESGYPYIMFE DTVNRANPID GKITHSNLCS EILQVSTPSL FNEDLSYAKV 

       430        440        450        460        470        480 
GKDISCNLGS LNIAKTMDSP DFAQTIEVAI RALTAVSDQT HIKSVPSIEQ GNNDSHAIGL 

       490        500        510        520        530        540 
GQMNLHGYLA RERIFYGSDE GIDFTNIYFY TVLYHALRAS NRIAIERGTH FKGFERSKYA 

       550        560        570        580        590        600 
SGEFFDKYTD QIWEPKTQKV RQLFADAGIR IPTQDDWRRL KESVQAHGIY NQNLQAVPPT 

       610        620        630        640        650        660 
GSISYINHST SSIHPIVSKV EIRKEGKIGR VYYPAPYMTN DNLEYYEDAY EIGYEKIIDT 

       670        680        690        700        710        720 
YAAATQHVDQ GLSLTLFFKD TATTRDVNKA QIYAWRKGIK TLYYIRLRQM ALEGTEVEGC 


VSCML

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References

[1]"The genome sequence of Mycobacterium tuberculosis strain KZN 1435."
Murray M., Pillay M., Borowsky M.L., Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.I., Hepburn T.A. expand/collapse author list , Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N., Walk T., White J., Yandava C., Haas B., Nusbaum C., Galagan J., Birren B.
Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KZN 1435 / MDR.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001658 Genomic DNA. Translation: ACT23957.1.
RefSeqYP_003030852.1. NC_012943.1.

3D structure databases

ProteinModelPortalC6DVK9.
SMRC6DVK9. Positions 26-710.
ModBaseSearch...

Protein-protein interaction databases

STRING478434.TBMG_00917.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACT23957; ACT23957; TBMG_00917.
GeneID8163954.
KEGGmtb:TBMG_00917.
PATRIC18159380. VBIMycTub122270_1006.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0209.
HOGENOMHOG000246165.
KOK00525.
OMAVSRIEIR.
ProtClustDBPRK08188.

Enzyme and pathway databases

BioCycMTUB478434:GH8E-950-MONOMER.
UniPathwayUPA00326.

Family and domain databases

InterProIPR013346. NrdE_NrdA.
IPR026459. RNR_1b_NrdE.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR013554. RNR_N.
IPR008926. RNR_R1-su_N.
[Graphical view]
PfamPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
PF08343. RNR_N. 1 hit.
[Graphical view]
PRINTSPR01183. RIBORDTASEM1.
SUPFAMSSF48168. Ribonucleo_red_N. 1 hit.
TIGRFAMsTIGR02506. NrdE_NrdA. 1 hit.
TIGR04170. RNR_1b_NrdE. 1 hit.
PROSITEPS00089. RIBORED_LARGE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC6DVK9_MYCTK
AccessionPrimary (citable) accession number: C6DVK9
Entry history
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info